Ultrasmall iron oxide nanoparticles: synthesis, surface modification, assembly, and biomedical applications

Song, Cong; Sun, Wenjie; Xiao, Yunchao; Shi, Xiangyang

doi:10.1016/j.drudis.2019.01.001

Cited by 82 publications

(56 citation statements)

References 91 publications

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) with a size less than 5 nm have attracted growing attention as emerging nanomaterials for biomedical applications, including magnetic resonance imaging (MRI), drug delivery and theranostics, due to their high biocompatibility, chemical stability, tunable surface features, prolonged blood circulation time due to the reduced phagocytosis by macrophages and T 1 -shortening effect (unlike larger iron oxide nanoparticles) in MRI [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation

Goldt¹,

Polyakov²,

Sorkina³

et al. 2019

Nanosystems: Phys. Chem. Math.

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Superparamagnetic iron oxide γ-Fe 2 O 3 (maghemite) nanoparticles (SPION) encapsulated into water-soluble microspheres of rock salt were synthesized via a new aerosol spray pyrolysis procedure. Humic acids (HA) were employed to stabilize the aqueous suspensions of γ-Fe 2 O 3 nanoparticles released upon dissolution of the NaCl matrix. The effect of HA on the surface charge of maghemite-based colloids was studied in pH range of 3 -10. Humic polyanions compensate positive charges on a hydrated γ-Fe 2 O 3 surface resulting in strongly negative ζ-potential (< −40 mV) of colloid even in acidic environment. In neutral and alkaline environment, ζ-potential of maghemite-based colloid drops below −55 mV; thus, HA should effectively stabilize the nanoparticle colloid over the whole pH range studied. Meanwhile, bare maghemite SPION at pH 3 -6 have ζ-potential in the +20 mV to −20 mV range (isoelectric point at pH 4.35), which is insufficient for electrostatic stabilization of the suspensions. The absence of embryotoxicity of HA-stabilized nanoparticles was demonstrated.

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Section: Introductionmentioning

confidence: 99%

“…To achieve enhanced colloidal stability and versatility of biomedical applications, numerous approaches have been developed for the surface modification of SPIONs employing the specifically designed synthetic ligands [1,5]. Meanwhile, the cheap and effective natural stabilizers for the SPIONs are still of high demand.…”

Section: Introductionmentioning

confidence: 99%

Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation

Goldt¹,

Polyakov²,

Sorkina³

et al. 2019

Nanosystems: Phys. Chem. Math.

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“…uorescence mediated tomography, uorescence reectance tomography, optical coherence tomography, a large number of uorescence microscopies, ow cytometry, spectrophotometry, intra-vital microscopy, intravascular non-invasive near-infrared (NIRF) imaging, clinical endoscopy, and equipment for uorescence detection during surgery. Such method can be used for monitoring magnetofection efficacy, 60 for multi-modal imaging with MPI, MRI and PAI, 61,62 for detecting various biological entities such as tumors, 16,56 apoptotic cells, 7 and sentinel lymph nodes, 4 and for delineating inltrating tumors such as glioblastoma. 63…”

Section: Optical Imaging Methodsmentioning

confidence: 99%

“…21 The review presented here is broader in scope than previous ones since it covers more imaging techniques and is not restricted to IONP synthesized by a specic method. [22][23][24][25] INOP advantages/drawbacks and parameters inuencing IONP their imaging power in these various imaging methods are summarized in Table 1 and Fig. 2.…”

Section: Introductionmentioning

confidence: 99%

Iron oxide nanoparticles as multimodal imaging tools

Alphandéry

2019

RSC Adv.

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“…Among nanoscale iron, superparamagnetic iron oxide NPs are widely studied for magnetic resonance imaging (MRI), for cancer treatment (Song et al 2019) and for targeting antibiotics (Armenia et al 2018), enzymes (Balzaretti et al 2017) and other drugs (Moros et al 2018). In addition, iron NPs functionalized with thermophilic enzymes might find their place also in industrial biotechnology (Armenia et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles

et al. 2019

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Iron nanoparticles (NPs) have been proposed as a tool in very different fields such as environmental remediation and biomedical applications, including food fortification against iron deficiency, even if there is still concern about their safety. Here, we propose Xenopus laevis embryos as a suitable model to investigate the toxicity and the bio-interactions at the intestinal barrier of Fe 3 O 4 and zerovalent iron (ZVI) NPs compared to Fe(II) and (III) salts in the 5 to 100 mg Fe/L concentration range using the Frog Embryo Teratogenesis Assay in Xenopus (FETAX). Our results demonstrated that, at concentrations at which iron salts induce adverse effects, both iron NPs do not cause acute toxicity or teratogenicity even if they accumulate massively in the embryo gut. Prussian blue staining, confocal and electron microscopy allowed mapping of iron NPs in enterocytes, along the paracellular spaces and at the level of the basement membrane of a well-preserved intestinal epithelium. Furthermore, the high bioaccumulation factor and the increase in embryo length after exposure to iron NPs suggest greater iron intake, an essential element for organisms. Together, these results improve the knowledge on the safety of orally ingested iron NPs and their interaction with the intestinal barrier, useful for defining the potential risks associated with their use in food/feed fortification.

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Ultrasmall iron oxide nanoparticles: synthesis, surface modification, assembly, and biomedical applications

Cited by 82 publications

References 91 publications

Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation

Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation

Iron oxide nanoparticles as multimodal imaging tools

Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles

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