Ultrasmall Pt Clusters Reducing Radiation-Induced Injuries via Scavenging Free Radicals

Xu, Fujuan; Mu, Xiaoyu; Wang, Junying; Bian, Peixian; Liu, Lingfang; Liu, Haile; Jing, Yaqi; Long, Wei; Liu, Changlong; Zhang, Xiao Dong

doi:10.1166/jbn.2017.2468

Cited by 16 publications

(10 citation statements)

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“…Obviously, the mean hydrodynamic size of single-and dual-ligand of Ag 25 clusterzymes is 3.6 nm (Figure S2), which is smaller than the threshold value of 5.5 nm for renal clearance. The UV−vis absorption spectroscopy confirms that Ag 25 MHA 18 shows three obvious absorption peaks at 336, 487, and 665 nm (Figure 1e), which are characteristic absorption peaks of Ag 25 (SR) 18 . In comparison, the 487 nm peak of Ag 25 clusterzymes is shifted slightly to 483 nm after doping with Cu, the 665 nm peak is shifted to 656 nm, and the 336 nm peak is shifted slightly to the long wavelength range.…”

Section: ■ Results and Discussionmentioning

confidence: 69%

“…High energy ionizing radiation plays an important role in cancer diagnosis and treatment. − However, in these processes, high-energy ionizing radiation can not only kill tumors but also damage normal tissues. − The high-energy radiation can induce ionization of H 2 O and further causes excessive reactive oxygen species (ROS) accumulation, including superoxide (O 2 •– ) hydrogen peroxide (H 2 O 2 ) and hydroxyl radicals ( • OHs). − Previous works have shown that nanozymes with multienzyme activities can participate in the redox process of free radicals. Therefore, the nanozyme can prevent tissues from oxidative stress damages by scavenging excess free radicals.…”

Section: Introductionmentioning

confidence: 99%

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Ligand-Modulated Catalytic Selectivity of Ag Clusterzyme for Relieving Multiorgan Injury via Inhabiting Acute Oxidative Stress

et al. 2021

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The artificial enzymes at the atomic level have shown great potential in chemical biology and nanomedicine, and modulation of catalytic selectivity is also critical to the application of nanozymes. In this work, atomic precision Ag25 clusterzymes protected by single- and dual-ligand were developed. Further, the catalytic activity and selectivity of Ag25 clusterzymes were modulated by adjusting doping elements and ligand. The Ag24Pt1 shows more prominent antioxidant activity characteristics in the dual-ligand system, while the Ag24Cu1 possesses the superoxide dismutase-like (SOD-like) activity regardless of the single- or dual-ligand system, indicating modulated catalytic selectivity. In vitro experiments showed the Ag24Pt1-D can recover radiation induced DNA damages and eliminate the excessive reactive oxygen species (ROS) generated from radiation. Subsequent in vivo radiation protection experiments reveal that Ag24Cu1-S and Ag24Pt1-D can improve the survival rate of irradiated mice from 0 to 40% and 30%, respectively. The detailed biological experiments confirm that the Ag24Cu1-S and Ag24Pt1-D can recover the SOD and 3,4-methylenedioxyamphetamine (MDA) levels via suppressing the chronic inflammation reaction. Nearly 60% of Ag24Cu1-S and Ag24Pt1-D can be excreted after a 1 day injection, and no obvious toxicological reactions were observed 30 days after injection.

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Section: ■ Results and Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Ligand-Modulated Catalytic Selectivity of Ag Clusterzyme for Relieving Multiorgan Injury via Inhabiting Acute Oxidative Stress

et al. 2021

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“…Catalytic nanomaterials have high activity of scavenging ROS (Marković et al, 2001; Panikkanvalappil et al, 2013; Zhang et al, 2015b; Xu et al, 2017). It is reported that 35% ROS can be scavenged by Pd nanocubes after H 2 O 2 stimulation (Ge et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Dislocation Engineered PtPdMo Alloy With Enhanced Antioxidant Activity for Intestinal Injury

Long

Wang

et al. 2019

Front. Chem.

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Radiotherapy is the mainstay for abdomen and pelvis cancers treatment. However, high energy ray would inflict gastrointestinal (GI) system and adversely disrupt the treatment. The anti-oxidative agents provide a potential route for protecting body from radiation-induced injuries. Herein, highly catalytic nanocubes with dislocation structure are developed for treatment of intestinal injury. Structural and catalytic properties show that Mo incorporation can enhance antioxidant activity by dislocation structure in the alloy. In vitro studies showed that PtPdMo improved cell survival by scavenging radiation-induced ROS accumulation. Furthermore, after animals were exposed to lethal dose of radiation, the survival was increased by 50% with the PtPdMo i.p. treatment. Radioprotection mechanism revealed that PtPdMo alleviated the oxidative stress in multi-organs especially the small intestine by inhibiting intestinal epithelium apoptosis, reducing DNA strands breaks and enhancing repairing ability. In addition, PtPdMo protected hematopoietic system by improving the number of bone marrow and peripheral blood cells.

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“…Xu et al synthesized ultrasmall Pt clusters with glutathione (GSH) as ligands that could alleviate radiation-induced damage in cells and animal models by scavenging free radicals (Figure 2). 90 Pt clusters exert their SOD-like activity to eliminate ROS induced by ionizing radiation and restore cellular redox levels. The comet assay experiments showed that after Pt cluster treatment, the tail moment of the irradiated DNA returned to near normal levels.…”

Section: Catalytic Nanozyme For Radiation Protectionmentioning

confidence: 99%

Catalytic Nanozyme for Radiation Protection

Zhao

Liu

et al. 2021

Bioconjugate Chem.

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Radiotherapy has been widely used in clinical cancer treatment. However, the ionizing radiation required to kill the tumor will inevitably cause damage to the surrounding normal tissues. To minimize the radiation damage and side effects, small molecular radioprotective agents have been used as clinical adjuvants for radiation protection of healthy tissues. However, the shortcomings of small molecules such as short circulation time and rapid kidney clearance from the body greatly hinder their biomedical applications. In recent years, nanozymes have attracted much attention because of their potential to treat a variety of diseases. Nanozymes exhibit catalytic properties and antioxidant capabilities to provide a potential solution for the development of high-efficiency radioprotective agents in radiotherapy and nuclear radiation accidents. Therefore, in this review, we systematically summarize the catalytic nanozymes used for radiation protection of healthy tissues and discuss the challenges and future prospects of nanomaterials in the field of radiation protection.

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Ultrasmall Pt Clusters Reducing Radiation-Induced Injuries via Scavenging Free Radicals

Cited by 16 publications

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Ligand-Modulated Catalytic Selectivity of Ag Clusterzyme for Relieving Multiorgan Injury via Inhabiting Acute Oxidative Stress

Ligand-Modulated Catalytic Selectivity of Ag Clusterzyme for Relieving Multiorgan Injury via Inhabiting Acute Oxidative Stress

Dislocation Engineered PtPdMo Alloy With Enhanced Antioxidant Activity for Intestinal Injury

Catalytic Nanozyme for Radiation Protection

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