Ultrasmall superparamagnetic iron oxide nanoparticles for enhanced tumor penetration

Abstract

The intrinsic pathological characteristics of tumor micrenvironment restrict the deep penetration of nanomedicines by passive diffusion. Magnetophoresis is a promising strategy to improve the tumor penetration of nanomedicines aided by...

Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures

“…It has been observed that the size and surface coating characteristics of the NPs ultimately determine their tissue deposition [ 181 , 182 , 183 ]. Additionally, smaller NPs (20 nm or less in diameter) have been found to penetrate tumor tissue more effectively [ 183 , 184 ]. It is worth noting that smaller particles have a tendency to remain in circulation for longer periods [ 185 , 186 ].…”

Surfactant-driven optimization of iron-based nanoparticle synthesis: a study on magnetic hyperthermia and endothelial cell uptake

“…an injection into the blood circulation, the particles will be in immediate contact with endothelial cells, which form the inner cell layer of blood vessels. While numerous studies have thoroughly examined the cellular uptake of magnetic nanoparticles by cancer cells, [21][22][23] our ndings provide valuable insights into the internalization of these nanoparticles by endothelial cells. Tumor endothelial cells differ from endothelial cells in normal tissues, including the presentation of certain surface molecules.…”