Ultrasmooth Gold Surfaces Prepared by Chemical Mechanical Polishing for Applications in Nanoscience

Miller, Michael S.; Ferrato, Michael-Anthony; Niec, Adrian; Biesinger, Mark C.; Carmichael, Tricia Breen

doi:10.1021/la5032027

Cited by 25 publications

(14 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are four main methods to prepare the metal substrates ( Figure 6), viz; (a) chemical mechanical polishing (CMP); (b) physical vapor deposition (PVD); (c) template stripping; and (d) annealing-assisted template stripping [11]. CMP and PVD are common method to make flat metal surface but with limited flatness [49]. For over two decades, template stripping has been the method of choice to make ultra-flat surface with low roughness (~0.4 nm) [49], see Section 3.2.…”

Section: Substrates Preparationmentioning

confidence: 99%

“…CMP and PVD are common method to make flat metal surface but with limited flatness [49]. For over two decades, template stripping has been the method of choice to make ultra-flat surface with low roughness (~0.4 nm) [49], see Section 3.2. The annealing-assisted template stripping generally involve two parts, an annealing step and a template stripping step.…”

Section: Substrates Preparationmentioning

confidence: 99%

See 1 more Smart Citation

The Porter-Whitesides Discrepancy: Revisiting Odd-Even Effects in Wetting Properties of n-Alkanethiolate SAMs

2015

View full text Add to dashboard Cite

This review discusses the Porter-Whitesides discrepancy in wetting properties of n-alkanethiolate self-assembled monolayers (SAMs). About 25 years ago, Whitesides and coworker failed to observe any odd-even effect in wetting, however, Porter and his coworker did, albeit in select cases. Most previous studies agreed with Whitesides' results, suggesting the absence of the odd-even effect in hydrophobicity of n-alkanethiolate SAMs. Recent reports have, however, found the odd-even effect in hydrophobicity of n-alkanethiolate SAMs on smooth substrates, indicating that hydrophobicity, and analogous interfacial properties, of n-alkanethiolate SAMs significantly depends on the properties of substrate. Unfortunately, the Whitesides and Porter papers do not report on the quality of the surfaces used. Based on recent work, we inferred that the original discrepancy between Whitesides and Porter can be attributed to the quality of the surface. Odd-even effect of SAMs in charge transport, capacitance, friction, and SAM structure are also discussed in this review to inform the general discussion. The discrepancy between Porter's group and Whitesides' group could be due to surface roughness, morphology, oxidation, and adventitious contaminants. OPEN ACCESSCoatings 2015, 5 1035

show abstract

Section: Substrates Preparationmentioning

confidence: 99%

Section: Substrates Preparationmentioning

confidence: 99%

The Porter-Whitesides Discrepancy: Revisiting Odd-Even Effects in Wetting Properties of n-Alkanethiolate SAMs

2015

View full text Add to dashboard Cite

show abstract

“…However, the size and shape of the resultant surface is determined by the spreading of the glass droplet, which is poorly controlled, and compulsory use of this material makes the technique impractical for other substrates. Miller et al use chemical mechanical polishing (CMP) on gold-coated substrates that can be used for very large areas (44 cm 2 ) 14 . Their roughness values are in the same range as TSG samples: ~0.35 nm root-mean-square (RMS) over 1 μm 2 areas.…”

Section: Introductionmentioning

confidence: 99%

Ultraflat Gold QCM Electrodes Fabricated with Pressure-Forming Template Stripping for Protein Studies at the Nanoscale

et al. 2019

View full text Add to dashboard Cite

Single-molecule imaging of proteins using atomic force microscopy (AFM) is crucially dependent on protein attachment to ultra-flat substrates. The technique of template stripping (TS), which can be used to create large areas of atomically flat gold, has been used to great effect for this purpose. However, this approach requires an epoxy which can swell in solution, causing surface roughening and substantially increasing the thickness of any sample, preventing its use on acoustic resonators in liquid. Diffusion bonding techniques should circumvent this problem

show abstract

“…Analysis by nanoIR2 (Anasys Instrument, USA) was performed on atomically flat and positive gold substrates with a nominal roughness of 0.36 nm (Platypus Technologies, USA) 43 . The root mean square roughness of the AFM maps was measured by SPIP (Image metrology, Denmark).…”

Section: Afm-ir Measurements Maps Treatment and Analysismentioning

confidence: 99%

Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Aβ42 Oligomers

Ruggeri

Habchi

Chia

et al. 2020

Preprint

View full text Add to dashboard Cite

Very significant efforts have been devoted in the last twenty years to developing compounds that can interfere with the aggregation pathways of proteins related to misfolding disorders, including Alzheimer's and Parkinson's diseases. However, no disease-modifying drug has become available for clinical use to date for these conditions. One of the main reasons for this failure is the incomplete knowledge of the molecular mechanisms underlying the process by which small molecules interact with protein aggregates and interfere with their aggregation pathways. Here, we leverage the single molecule level morphological and chemical sensitivity of infrared nanospectroscopy to provide the first direct measurement of the interaction between single A42 oligomeric and fibrillar species and an aggregation inhibitor, bexarotene, originally an anticancer drug capable recently shown to be able to inhibit A42 aggregation in animal models of Alzheimer's disease.Our results demonstrate that the carbonyl group of this compound interacts with A42 aggregates through a single hydrogen bond. These results establish infrared nanospectroscopy as powerful tool in structure-based drug discovery for protein misfolding diseases.Alzheimer's disease (AD) is characterised by memory loss and cognitive impairment. AD is the primary cause of dementia, which affects currently over 50 million people worldwide, a number expected to exceed 150 million by 2050. 1-3 The self-assembly of the 42-residue isoform of the amyloid- (A) peptide into intractable aggregates is considered to be at the core of the molecular pathways leading to AD. [3][4][5] It is therefore important to understand at the molecular level the aggregation process of A42 in order to develop effective therapeutic strategies that aim at inhibiting its self-assembly.Great efforts have been devoted in the last twenty years to understand the molecular basis of this devastating disorder and to develop small molecules that could interfere with the aggregation pathway of A42. 6-12 Indeed, disease-modifying small molecules represent c.a. one third of the registered trials, in which anti-A therapies dominate. 13 However, despite these efforts, no compound has entered the clinical use to date. 13,14 These repeated failures are in part related to an incomplete understanding of the molecular mechanisms underlying the process by which small molecules interact with protein aggregates and how they interfere with the pathways of aggregation. It is increasingly recognised that inhibiting A aggregation per se could have unexpected consequences on the toxicity, as it could not only decrease it, but also leave it unaffected, or even increase it. 15 This complexity is due to the non-linear nature of the aggregation network, in which neurotoxic small oligomeric intermediates [16][17][18][19][20] , can be formed in a variety of ways, some of which highly sensitive to small perturbation. Therefore, promising effective therapeutic strategies must be aimed at targeting precise species in a controlled inte...

show abstract

Ultrasmooth Gold Surfaces Prepared by Chemical Mechanical Polishing for Applications in Nanoscience

Cited by 25 publications

References 66 publications

The Porter-Whitesides Discrepancy: Revisiting Odd-Even Effects in Wetting Properties of n-Alkanethiolate SAMs

The Porter-Whitesides Discrepancy: Revisiting Odd-Even Effects in Wetting Properties of n-Alkanethiolate SAMs

Ultraflat Gold QCM Electrodes Fabricated with Pressure-Forming Template Stripping for Protein Studies at the Nanoscale

Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Aβ42 Oligomers

Contact Info

Product

Resources

About