Ultrasonic assisted extraction of artemisinin from <i>Artemisia Annua</i> L. using monoether-based solvents

Zhang, Yongqiang; Prawang, Phongphat; Li, Chunshan; Meng, Xiangzhan; Zhao, Yu; Wang, Hui; Zhang, Suojiang

doi:10.1039/c7gc03191b

Cited by 33 publications

(26 citation statements)

References 41 publications

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“…This system utilises a special column packed with much smaller particles (typically 1.5–1.7 mm), instead of 3 or 5 mm particles used routinely in column packing for phytochemical analysis. The application of UPLC methods in the analysis of artemisinin ( 1 ) has also become more frequent recently . Ruan et al .…”

Section: Discussionmentioning

confidence: 99%

“…Zhang et al . reported an ultrasound extraction protocol for artemisinin ( 1 ) using mono‐ether based solvents, e.g.…”

Section: Extractionmentioning

confidence: 99%

“…ultrasoundassisted extraction, utilising various computational tools and mathematical modelling, has been observed in recent years. During the period from 2017 to present, several protocols of ultrasound-assisted extraction and SFE of artemisinin (1) have been reported (Table 1), [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] which will be discussed briefly in the following subsections.…”

Section: Extractionmentioning

confidence: 99%

“…propylene glycol methyl ether. 19 Box-Behnken experimental design was employed for ultrasound-assisted extraction of artemisinin (1) from A. annua using ethanol as the solvent. 20 Ultrasound-assisted extraction of artemisinin (1) from the leaves of A. annua was performed using a deep eutectic solvent.…”

Section: Ultrasound-assisted Extractionmentioning

confidence: 99%

“…Zhang et al 19 reported an ultrasound extraction protocol for artemisinin (1) Ruan et al 17 reported an ultrasound extraction method for artemisinin (1), where an orthogonal experiment was used. The ratio of material to liquid, extraction time and number of extractions were selected as the investigation factors.…”

Section: Ultrasound-assisted Extractionmentioning

confidence: 99%

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A review on the latest advances in extraction and analysis of artemisinin

Nahar

Chen

Sarker

2019

Phytochemical Analysis

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Introduction Artemisinin (1), a well‐known natural antimalarial drug, is a sesquiterpene lactone that contains a unique peroxide bridge. Since its discovery, the amount of research into the analysis of artemisinin has increased considerably, and it has been further intensified since the Noble Prize win by Tu Youyou in the year 2015 for the discovery of artemisinin. Objective To review literature on the extraction and analysis of artemisinin, published during 2017–present, and to present an appraisal of those methods. Methodology Extensive literature search was carried out which involved, but not limited to, the use of, various databases, like Web of Knowledge, PubMed and Google Scholar, and relevant published materials including published books. The keywords used, in various combinations, with artemisinin being present in all combinations, in the search were artemisinin, Artemisia annua, analysis, extraction, quantitative, qualitative and quality control. Results During the period covered in this review, several methods of analysis of artemisinin have been reported, the most of which were liquid chromatography (LC)‐based methods. However, the use of new methods like near‐infrared analysis, fluorometirc analysis and molecular imprinting, and a significant increase in the use of computational tools have been observed. Mainly several methods involving supercritical fluid extraction and ultrasound‐assisted extraction of artemisinin have dominated the extraction area. Conclusions Newer analytical tools, as well as improved protocols for the known analytical tools, for qualitative and quantitative determination of artemisinin (1), have been made available by various researchers during the period covered by this review. Supercritical fluid extraction and ultrasound‐assisted extraction are still the methods of choice for extraction of artemisinin.

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Section: Discussionmentioning

confidence: 99%

“…Zhang et al . reported an ultrasound extraction protocol for artemisinin ( 1 ) using mono‐ether based solvents, e.g.…”

Section: Extractionmentioning

confidence: 99%

Section: Extractionmentioning

confidence: 99%

Section: Ultrasound-assisted Extractionmentioning

confidence: 99%

Section: Ultrasound-assisted Extractionmentioning

confidence: 99%

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A review on the latest advances in extraction and analysis of artemisinin

Nahar

Chen

Sarker

2019

Phytochemical Analysis

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Instant determination of the artemisinin from various Artemisia annua L. extracts by LC‐ESI‐MS/MS and their in‐silico modelling and in vitro antiviral activity studies against SARS‐CoV‐2

Doğan

Erol

Orhan

et al. 2021

Phytochemical Analysis

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Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L. shows some promise for the treatment of SARS‐CoV‐2. Objective The main objective of our study was to determine artemisinin content by liquid chromatography electrospray ionisation tandem mass spectrometry (LC‐ESI‐MS/MS), to investigate the in vitro biological activity of artemisinin from the A. annua plants grown in Turkey with various extracted methods, to elaborate in silico activity against SARS‐CoV‐2 using molecular modelling. Methodology Twenty‐one different extractions were applied. Direct and sequential extractions studies were compared with ultrasonic assisted maceration, Soxhlet, and ultra‐rapid determined artemisinin active molecules by LC‐ESI‐MS/MS methods. The inhibition of spike protein and main protease (3CL) enzyme activity of SARS‐CoV‐2 virus was assessed by time resolved fluorescence energy transfer (TR‐FRET) assay. Results Artemisinin content in the range 0.062–0.066%. Artemisinin showed significant inhibition of 3CL protease activity but not Spike/ACE‐2 binding. The 50% effective concentration (EC50) of artemisinin against SARS‐CoV‐2 Spike pseudovirus was found greater than 50 μM (EC45) in HEK293T cell line whereas the cell viability was 94% of the control (P < 0.01). The immunosuppressive effects of artemisinin on TNF‐α production on both pseudovirus and lipopolysaccharide (LPS)‐induced THP‐1 cells were found significant in a dose dependent manner. Conclusion Further studies of these extracts for COVID‐19 treatment will shed light to seek alternative treatment options. Moreover, these natural extracts can be used as an additional treatment option with medicines, as well as prophylactic use can be very beneficial for patients.

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