Ultrasonic cavitation monitoring by acoustic noise power measurement

Frohly, J.; Labouret, Stéphane; Bruneel, C.; Looten-Baquet, I.; Torguet, R.

doi:10.1121/1.1312360

Cited by 146 publications

(113 citation statements)

References 30 publications

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“…Therefore, a larger CNP means that a larger acoustic signal generated by the cavitation will be observed. In this paper, cavitation generation was evaluated by the relative CNP (ReCNP) [10], expressed as…”

Section: Evaluation Of Cavitation Generationmentioning

confidence: 99%

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Quantitative evaluation of hemolysis in bovine red blood cells caused by acoustic cavitation under pulsed ultrasound

Tani

Imura

Koyama

et al. 2017

Acoust. Sci. & Tech.

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IntroductionThe safety criteria of ultrasound for live bodies are one of the important factors in the development of ultrasound imaging and therapeutic techniques using high-intensity ultrasound such as shear-wave elastography [1] and highintensity focused ultrasound therapeutic techniques [2]. These functional techniques enable the visualization of additional information and expected treatment effects. However, the local temperature rise and high stress caused by high-intensity ultrasound will induce biological effects. Several researchers have reported the effects on blood under high stress or highintensity ultrasound [3,4]. The effect on blood can be evaluated quantitatively by the amount of hemolysis, in which the cell membrane of red blood cells is ruptured by physical, chemical and biological factors, and hemoglobin included in the red blood cells flows out plasma [5]. Our group has developed an ultrasonic bubble filter for extracorporeal circulation and investigated its effect on blood [6,7], and it was found that ultrasound exposure at lower frequencies induced greater damage to blood at the same sound pressure level. These experimental results imply that the hemolysis is related to acoustic cavitation since the sound pressure threshold for cavitation generation increases with the ultrasound frequency. Acoustic cavitation increases the dose efficiency in ultrasound-triggered gene and drug delivery techniques [8], and the ultrasound pulse length is one of the important factors in cavitation generation and in determining the efficiency [9].In this paper, we focused on hemolysis caused by pulsed ultrasound and performed in vitro experiments using bovine blood. Temporal changes in the generation of cavitation were measured while changing the pulse repetition frequency (PRF) and pulse length, and the relationship between the hemolysis and the acoustic cavitation was evaluated quantitatively.

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Section: Evaluation Of Cavitation Generationmentioning

confidence: 99%

“…The cavitation noise power indicator (CNP) [10] was used for an evaluation index of cavitation generation. The CNP can be estimated from the frequency spectrum of an observed ultrasound waveform pðtÞ and is expressed as…”

Section: Evaluation Of Cavitation Generationmentioning

confidence: 99%

Quantitative evaluation of hemolysis in bovine red blood cells caused by acoustic cavitation under pulsed ultrasound

Tani

Imura

Koyama

et al. 2017

Acoust. Sci. & Tech.

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“…Different components in the spectrum represent pressures from the direct field, stable cavitation, and transient cavitation [7,13]. The frequency and pressures from the direct field, stable and transient cavitation are recorded in SI units (i.e., Hertz and Pascal).…”

Section: Conical Transducermentioning

confidence: 99%

“…A calibrated needle hydrophone ( Figure 2) was used to measure the acoustic direct field (that propagated from the source) and the two forms of cavitation, stable and transient [6,7], which are generated by the presence of the direct field. It has been shown that both forms of cavitation closely relate to cleaning efficiency and damage [10].…”

Section: Needle Hydrophonementioning

confidence: 99%

Acoustic characterization of two megasonic devices for photomask cleaning

Zanelli¹,

Dushyanth²,

Keswani

et al. 2016

SPIE Proceedings

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“…High-frequency components (i.e., in the megahertz range) of the output signal from the sensor were analyzed. These high-frequency components originate from shockwaves caused by the collapse and vibration of bubbles produced by acoustic cavitation [9,10]. The high-frequency components in the output signal were converted into Broadband Integrated Voltage (BIV) [7,8].…”

Section: Introductionmentioning

confidence: 99%

Characterization of output signal from hollow cylindrical cavitation sensor

Uchida

Sato

Takeuchi

et al. 2010

Acoust. Sci. & Tech.

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IntroductionRecently, acoustic cavitation generated by high-pressure ultrasound has been investigated for medical therapeutic applications such as medication and gene therapy by sonoporation [1,2]. Meanwhile, cavitation can damage healthy cells in the human body. Therefore, it is necessary to control cavitation to ensure its suitable use in the medical field. However, there is currently no quantitative method for measuring the amount of generated cavitation required for the control. Therefore, ensuring the safety of the cavitation for the human body is a serious problem.In the field of sonochemistry, several applications that exploit the effect of cavitation have been proposed. For example, cavitation has been investigated for producing advanced materials such as carbon nanotubes [3] and for dispersing nanometer sized diamond particles [4]. In the future, it is expected that industrial applications of sonochemistry will be developed. However, the lack of a quantitative technique for measuring the amount of generated cavitation has hindered the development of such applications.Previously, the generation of cavitation by sound pressure, as typified by the mechanical index (MI), has been investigated in medical field [5]. However, it is necessary to measure the amount of cavitation generated both for highly accurate investigations on the effect of cavitation on the human body for medical applications and for technical advances in sonochemistry. Therefore, it is important to develop a technique for measuring the amount of generated cavitation.We have been studying the quantitative measurement of acoustic cavatation. Zeqiri et al. in National Physical Laboratory (UK) proposed a method that employs a hollow cylindrical cavitation sensor [6][7][8]. To enable this method to be used in practical applications it is important to consider the relationships between the output voltage from the sensor, the cavitation generation conditions, and the secondary effects of the cavitation. In this work, we investigated the characteristics of the output voltage from a hollow cylindrical cavitation sensor by using the dissolved oxygen (DO) level of distilled water and sonochemical luminescence.

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Ultrasonic cavitation monitoring by acoustic noise power measurement

Cited by 146 publications

References 30 publications

Quantitative evaluation of hemolysis in bovine red blood cells caused by acoustic cavitation under pulsed ultrasound

Quantitative evaluation of hemolysis in bovine red blood cells caused by acoustic cavitation under pulsed ultrasound

Acoustic characterization of two megasonic devices for photomask cleaning

Characterization of output signal from hollow cylindrical cavitation sensor

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