Ultrasonic Velocity Studies of Drug Parvon-spas in Mixed Alcohol–Water Solvent Systems at 25°C

Abstract

Ultrasonic velocities and densities of the drug Parvon-spas in binary mixtures of water with methanol (MeOH), ethanol (EtOH), and propan-1-ol (1-PrOH) have been measured over the complete solvent composition range at 10 mol% intervals at 25 • C. Various acoustic parameters such as the acoustic impedance (Z), adiabatic compressibility (β), intermolecular free length (L f ), relative association (R.A.), molar volume (V m ), and molar sound velocity (R m ) have been calculated. In addition, excess functions, i.e., excess adiabatic compressibility (β E ), excess intermolecular free length (L E f ), excess molar volume (V E ), excess ultrasonic velocity (U E ), and excess acoustic impedance (Z E ) for these three solvent mixtures in the absence and presence of the drug have been calculated. A different behavior of these parameters in these alcohol systems has been discussed in terms of the length of the alcohol molecule, the molecular volume, as well as inter/intramolecular interactions of these molecules.

Studies of Partial Molar Volumes of Some Narcotic-Analgesic Drugs in Aqueous-Alcoholic Mixtures at 25°C

“…All measurements were carried out at 25 ± 0.01 • C in a water thermostat using a calibrated sealable pycnometer. The density values for MeOH, EtOH, and 1-PrOH were in good agreement with literature values [5,6].…”

“…Fine-Chem. Ltd.) were dried on 4-Å molecular sieves for 24 h and were purified as reported in the literature [4,5]. Doubly distilled water was used in the entire work.…”

Effects of concentration and solvent composition on the electrical conductivity of sodium bromide in pure water and ethanol-water mixed solvent media

“…The density is decreased with the increase of alcohol content for the ethanol-water mixed solvent system. This behaviour has been found to be similar in the literatures [15,16,17]. As a liquid becomes warmer, the molecules spread out more.…”

Volumetric, ultrasonic speed, and viscometric studies of salbutamol sulphate in aqueous methanol solution at different temperatures

“…The solution behaviour of alcohol molecules in the water region is largely established by the phenomenon of a polar or hydrophobic hydration [2]. There are some reports available in the literature on the volumetric and transport properties of some drugs in aqueous methanol solution system [3][4][5]. The partial molar volume is a characteristic parameter which is indicative of molecular interactions in the solution phase.…”