Ultrasonic welding method to fabricate polymer microstructure encapsulating protein with minimum damage

Min, Jun; Park, Jung Hwan; Yoon, Hyon Hee; Choy, Young Bin

doi:10.1007/bf03218562

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…Microneedles made of dextrin, chondroitin sulfate and albumin were similarly fabricated one-by-one by drawing using pipette tips [125–126]. An ultrasonic welding method was also introduced to form biodegradable polymer microneedles out of polymer particles welded together without bulk heating of the polymer, which resulting in minimal damage to encapsulated compounds [139–140]. …”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

Microneedles for drug and vaccine delivery

Kim

Park

Prausnitz

2012

Advanced Drug Delivery Reviews

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Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990’s when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.

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Section: Fabrication Of Microneedlesmentioning

confidence: 99%

Microneedles for drug and vaccine delivery

Kim

Park

Prausnitz

2012

Advanced Drug Delivery Reviews

Self Cite

1,404

1,036

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“…Dissolving MNs are typically fabricated by micro-molding, but they have also been fabricated by drawing up liquid formulation to form tapered MNs at high enough temperature, and then solidified by cooling [50]. Ultrasonic welding approach has also been used with micro-molding to fabricate biodegradable MNs [62,63]. In this way, damage to encapsulate compounds was effectively controlled by welding polymer particles together without bulk heating of the polymer.…”

Section: Categorized By Drug Transportation Methodsmentioning

confidence: 99%

Microneedle, bio-microneedle and bio-inspired microneedle: A review

2017

Journal of Controlled Release

340

198

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Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows them with many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs. Secondly, researches on inserting behavior and mechanical performances of MNs are discussed. Thirdly, literatures on the drug delivery and the pain resulted from the insertion of MNs are overviewed. Finally, some bio-microneedles and bio-inspired MNs are introduced.

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“…1,2 Specifically, biopolymer-based composites fabricated from two or more biopolymers with different physical or chemical properties offer an increased amount of innovative activities for use with various biological applications in tissue engineering, wound healing, biosensor design, imaging, and drug delivery. [3][4][5][6][7][8][9] Although the incorporation of two or more biopolymers to prepare biopolymer-based composites is required to form them into various shapes through electrospinning, molding with templates, or casting to form films, the fabrication of biopolymer-based composites is still a highly challenging task due to the low solubility of many biopolymers used in most conventional solvents. 10,11 However, ionic liquids (ILs) have excellent potential for the dissolution of biopolymers so that two or more biopolymers can be reconstituted into different shapes of biopolymer-based composites, such as fibers, films or monoliths, when a co-solvent such as water, alcohol or acetone is added to a biopolymers-IL solution.…”

Section: Introductionmentioning

confidence: 99%