Ultrasonication techniques used for the preparation of novel Eugenol-Nanoemulsion in the treatment of wounds healings and anti-inflammatory

Ahmad, Niyaz; Alam, Aftab; Ahmad, Farhan Jalees; Sarafroz,; Ansari, Khalid; Sharma, Sonali; Amir, Mohd

doi:10.1016/j.jddst.2018.06.003

Cited by 49 publications

(40 citation statements)

References 59 publications

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“…11 There have been so many investigations reported recently in which drugs are carried inside the core of NEs which easily penetrate into the skin via the subcutaneous barrier. 12,13 Therefore, it is a novel approach to design a new formulation that can increase curcumin solubilization and increase its permeation via the skin. There are so many studies reported related to the improvement of solubility and dissolution with the use of different techniques, including polymeric nanoparticles, nanoemulsions, complexation, etc.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

et al. 2019

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“…The first one is the CEO-NE system with distinctive characteristics such as nanometric size that facilitates its cellular uptake by immune cells, like macrophages, in the inflamed tissues 74 as well as penetration enhancement ability conferred by the surfactant (tween-80 ® ) as one of its components, therefore augmenting the drug cutaneous permeation. [75][76][77][78] The second factor is the permeation pattern of both formulae either controlled (NEG) or sustained (NFs) that has a great influence in decreasing the frequency of dosing at the application site, thence improving the patient compliance for the treatment regimen as well as being cost-effective for prospective commercial production on large scale.…”

Section: In Vivo Anti-inflammatory Activity Against Croton Oil-inducementioning

confidence: 99%

<p>Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation</p>

Aman¹,

Hashim²,

Meshali³

2020

IJN

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Purpose: Clove essential oil is a phytochemical possessing a vast array of biological activities. Nevertheless, fabricating nano topical delivery systems targeted to augment the anti-inflammatory activity of the oil has not been investigated so far. Accordingly, in this study, controlled release nanoparticulate systems, namely nanoemulgel and nanofibers (NFs), of the oil were developed to achieve such goal. Methods: The nanoemulsion was incorporated in the hydrogel matrix of mixed biopolymerschitosan, guar gum and gum acaciato formulate nanoemulsion-based nanoemulgel. Taguchi's model was adopted to evaluate the effect of independently controlled parameters, namely, the concentration of chitosan (X 1), guar gum (X 2), and gum acacia (X 3) on different dependently measured parameters. Additionally, the nanoemulsion-based NFs were prepared by the electrospinning technique using polyvinyl alcohol (PVA) polymer. Extensive in vitro, ex vivo and in vivo evaluations of the aforementioned formulae were conducted. Results: Both Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) established the complete dispersion of the nanoemulsion in the polymeric matrices of the prepared nanoemulgel and NFs. The ex vivo skin permeation data of clove essential oil from the prepared formulations showed that NFs can sustain its penetration through the skin comparably with nanoemulgel. Topical treatment with NFs (once application) and nanoemulgel (twice application) evoked a marvelous in vivo anti-inflammatory activity against croton oil-induced mouse skin inflammation model when compared with pure clove essential oil along with relatively higher efficacy of medicated NFs than that of medicated nanoemulgel. Such prominent anti-inflammatory activity was affirmed by histopathological and immunohistochemical examinations. Conclusion: These results indicated that nanoemulsion-based nanoemulgel and nanoemulsion-based NFs could be introduced to the phytomedicine field as promising topical delivery systems for effective treatment of inflammatory diseases instead of nonsteroidal antiinflammatory drugs that possess adverse effects.

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“…Further, they characterized eugenol nanoemulsion-gel for pH, gelling capacity, syringeability, mucoadhesion, irritancy studies and in vitro drug release. 15 Hence, it can be concluded that treatment with eugenol can be effective therapeutic approach which can overcome these dental problems. As per our literature survey, surprisingly, so far no research attempt has been made to formulate toothpaste with isolated active principle of clove, eugenol.…”

Section: Introductionmentioning

confidence: 99%

Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste

Shete¹,

Patmas²,

Patil³

2020

IJPER

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Introduction: Formation of cavities and hyper sensitivity are few dental problems, manifested by dental pain. Since long back, volatile oil present in clove buds (Myrtaceae) have been used as dental analgesic. Various toothpastes containing clove oil are marketed. Eugenol is chemically, terpenoids, active principle present in clove oil. It has several pharmacological potentials. Pro-argin technology is novel approach for formulation of toothpaste with arginine (8%) and calcium carbonate. Aim: This research was aimed towards formulation of toothpaste containing eugenol by Pro-argin technology and its evaluation. Materials and Methods: Toothpaste containing eugenol was formulated with arginine (8%) and calcium carbonate by simple trituration. Formulation was then evaluated for various parameters like pH, spreadability, foaming ability, content determination and also analysed for texture. Results and Discussion: On formulation, brownish, aromatic fragrant toothpaste was obtained with acceptable pH, spreadability and foaming ability. About 92.48% of eugenol content of added quantity was determined. Conclusion: Eugenol can successfully be formulated in toothpaste by Pro-Argin approach. More than 90% content determination would facilitate maximum release of added eugenol.

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Ultrasonication techniques used for the preparation of novel Eugenol-Nanoemulsion in the treatment of wounds healings and anti-inflammatory

Cited by 49 publications

References 59 publications

Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

<p>Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation</p>

Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste

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