Ultrasonographic findings in ceftriaxone: associated biliary sludge and pseudolithiasis in children

Abstract

The combination of oral restriction and surgical procedures may be a causal factor in ceftriaxone-associated biliary pseudolithiasis. It is emphasized that when gallstone and/or sludge are detected in the gallbladder in children by ultrasonographic examination, the administration of ceftriaxone must be sought beyond other causative factors.

Pseudolithiasis due to Ceftriaxone Treatment for Meningitis in Children: Report of 8 Cases

“…The incidence of ceftriaxone-associated biliary sludge was reported between 17-57.5% (Schaad et al 1988;Papadopoulou et al 1999;Palanduz et al 2000;Herek et al 2001;Bor et al 2004;Ozturk et al 2005). Higher rates were reported with higher doses of ceftriaxone in those studies (100 mg/kg/day vs 60-70 mg/kg/day).…”

“…Higher rates were reported with higher doses of ceftriaxone in those studies (100 mg/kg/day vs 60-70 mg/kg/day). The highest incidence for ceftriaxone-associated biliary sludge was reported by Ozturk et al (2005). The authors explained the high incidence with several reasons: high dose of ceftriaxone (100 mg/kg/day), restriction of oral intake in half of the patients and the high weather temperature in summer in their region.…”

Spontaneously resolved biliary sludge in a term neonate; A case report

“…İçeriklerinde daha az oranda kalsiyum bilirubinat granülleri veya nadiren diğer kalsiyum tuzları bulunmaktadır [1][2][3] . Oluşum nedenleri arasında safra akımını yavaşlatan durumlar, hamilelik, hızlı kilo kaybı, total parenteral nutrisyon, uzamış açlık, kemik iliği ve solid organ nakli, çeşitli ilaçlar (octreotide, seftriakson gibi), hiportoidizm bulunur [1][2][3][4][5][6] . Ancak çoğu olguda neden bulunamaz.…”

“…Nadiren safra koliği, idiopatik pankreatit, kolanjit, akut kolesistit gibi komplikasyonları bildirilmiştir [3][4][5] . Klinik yaklaşım asemptomatik olgularda periyodik olarak izlem şeklindedir.…”

Prediction of Compatibility between Ozagrel Sodium Preparation for Injection and Calcium on the Basis of the Solubility Product

“…The mixture of ceftriaxone and calcium ion is known to have the potential to cause incompatibility, resulting in biliary sludge and pseudocholelithiasis; even death has been reported. [12][13][14][15][16][17] In the case of ozagrel-calcium, the ionic product was less than 25% of the K sp . That is, the SI was <1, indicating that the solution was unsaturated, and the presence of ozagrel-calcium salts is unlikely.…”