Ultrasonographic Findings in Patients with Benign and Malignant Thyroid Nodules who underwent Ultrasound Guided Fine Needle Aspiration Cytology

Majstorov, Venjamin

doi:10.3889/oamjms.2015.124

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…The results also differ from a prospective study conducted at our Institute in the period 2012–2013 by Majstorov, when a total of 684 nodules were evaluated cytopathologically, 78 patients with FNAB were surgically treated and histopathological findings were used for comparison and evaluation. The findings from this study showed a sensitivity of 87.5%, specificity of 92.5%, PPV, NPV value and accuracy of 67.7%,67.7%, and 76.3% respectively 14 …”

Section: Discussionmentioning

confidence: 51%

“…The findings from this study showed a sensitivity of 87.5%, specificity of 92.5%, PPV, NPV value and accuracy of 67.7%,67.7%, and 76.3% respectively. 14 The reasons for the difference in the described accuracy of the method in our analysis are probably due to several limitations, such as the retrospective nature of the study, the long evaluated period of 17-years in which there was a change in the classification system for interpretation of the cytopathological findings, change in performing FNAB from free hand technique to ultrasound-guided FNAB from 2012. Data from literature showed difference in diagnostic accuracy of free hand FNAB from US guided FNAB.…”

Section: Discussionmentioning

confidence: 91%

“…The reasons for the difference in the described accuracy of the method in our analysis are probably due to several limitations, such as the retrospective nature of the study, the long evaluated period of 17‐years in which there was a change in the classification system for interpretation of the cytopathological findings, change in performing FNAB from free hand technique to ultrasound‐guided FNAB from 2012. Data from literature showed difference in diagnostic accuracy of free hand FNAB from US guided FNAB 14 . Zhong LC et al also analyzed the effectiveness of the FNAB in evaluating nodes of different dimensions 15 .…”

Section: Discussionmentioning

confidence: 99%

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Ultrasound features and preoperative accuracy of the fine needle aspiration biopsy in detection of thyroid carcinomas

Makazlieva

Rizova

Stojanoski

et al. 2022

J of Clinical Ultrasound

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Objective To analyze the ultrasound (US) characteristics and fine needle biopsy (FNAB) of thyroid carcinomas (TCs) prior to surgery and compare with postoperative histopathology and to determine FNAB sensitivity and specificity. Material and Methods Retrospective analysis of the US data during 1999–2015 was performed, as well as analysis of FNAB results and using histopathology report as “gold standard” the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of this method was evaluated. Results Data revealed that tumors >51 mm were declining by 50% in the period 2011–2015 compared to 2005–2010 or by 18% 2011–2015 compared to 1999–2004 and significant increase was detected in diagnosis of multicentric tumors. The analysis revealed that FNAB has sensitivity = 65.7% CI (0.59% ‐ 0.71%) and specificity = 50% CI (0.43%–0.56%), PPV = 56.9% and NPV = 59.2%. Conclusion We found increasing detection of smaller TCs, as well as more frequent detection of multicentricity of the neoplastic foci. FNAB results in our study revealed low sensitivity and specificity. Major limitation of the study was inability to exactly separate US guided from non US guided FNAB in evaluation of the sensitivity and specificity, due to retrospective nature of the analysis. Further studies evaluating only US guided FNAB should be performed.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Ultrasound features and preoperative accuracy of the fine needle aspiration biopsy in detection of thyroid carcinomas

Makazlieva

Rizova

Stojanoski

et al. 2022

J of Clinical Ultrasound

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“…The sonographic features of PTC mainly included solid composition, hypo-echogenicity, aspect ratio ≥ 1, irregular margin, and microcalci cations [12,18]. However, these features were mainly based on the studies of nodules in lateral lobe.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Ultrasonographic Features of Papillary Thyroid Carcinoma Located in the Isthmus

Fan

Zhou

Zhan

et al. 2021

Preprint

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Purpose: To investigate the clinical and ultrasonographic features of papillary thyroid carcinoma (PTC) in the isthmus.Methods: A total of 823 patients with 823 PTCs including 133 in the isthmus and 690 in the lateral lobe were included in our study. All patients were confirmed by post-operative pathology. The clinical and ultrasonographic characteristics were retrospectively analyzed and compared. Univariate analysis and multivariate logistic regression analysis were performed.Results: Multi-factor analyses showed that PTC in the isthmus was significantly different from PTC originating from the lateral lobe in aspect ratio, microcalcification, extrathyroid extension, lymph node metastasis（LNM）, lymph node density（LND） (P < 0.05, for all). There were no significant differences in age, gender, tumor size, margin, halo, echogenicity and homogeneity (P > 0.05, for all).Conclusions: The sonographic appearance of PTC in the isthmus was not typical, however, it had a higher incidence of extrathyroidal extension, central lymph node involvement and a tendency of higher lymph node density. Therefore, more careful ultrasound evaluation should be performed for these nodules.

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“…The main component of microcalcification is calcium oxalate crystal (11). The major mechanism of microcalcification formation is as follows (12,13): i) thrombus is formed in the fibrovascular core of thyroid nodules, which develops into infarction, or necrosis of metastatic tumor cell nests in the lymph vessels occurs and triggers calcium deposit in dead tumor cells, thus forming gravel-like microcalcification. ii) The normal tumor cells in the thyroid nodules can release metabolic products and lead to dystrophic calcification of tumor cells, but such a calcification has no association with the apoptosis and necrosis of the tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Value of differential diagnosis of contrast‑enhanced ultrasound in benign and malignant thyroid nodules with microcalcification

Gao

Yan

2019

Oncol Lett

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Value of differential diagnosis of contrast-enhanced ultrasound in benign and malignant thyroid nodules with microcalcification was explored. A total of 184 patients with thyroid nodules with microcalcification, treated in People's Hospital of Shanxi Province from April 2015 to March 2017, were selected as research subjects. Contrast-enhanced ultrasound was used for imaging examination of the thyroid nodules. Three regions of interest were drawn at the positions with the strongest ultrasound imaging, for which the time-intensity curve (TIC), time to peak (Tp), peak intensity (Peak), area under curve (AUC) and mean transit time (MTT) were obtained separately. The features of contrast-enhanced ultrasound for malignant thyroid nodules were manifested as irregular focus edge, unclear boundary, low fiber reinforcement of the whole focus, uneven distribution of images and blood perfusion defect inside the focus, especially severe blood perfusion defect in the nodule center. The TIC showed a slow ascending and slow descending trend in general. The TIC features and the features of contrast-enhanced ultrasound for malignant thyroid nodules were prominently different from those for benign thyroid nodules. Compared with those in the surrounding normal tissues of thyroid gland, the Peak was remarkably shorter, and the AUC was notably smaller in the center and edge of malignant thyroid nodules (P<0.05); and the nodule center had obviously shorter Peak and smaller AUC than the nodule edge (P<0.05). Furthermore, in comparison with those of malignant thyroid nodules, the Peak was extended and AUC was enlarged markedly in the center and edge of benign thyroid nodules (P<0.05). In conclusion, the contrast-enhanced ultrasound can preferably compare the lesions of benign and malignant thyroid nodules with microcalcification, which possesses certain value in the differential diagnosis of benign and malignant thyroid nodules.

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Ultrasonographic Findings in Patients with Benign and Malignant Thyroid Nodules who underwent Ultrasound Guided Fine Needle Aspiration Cytology

Cited by 8 publications

References 17 publications

Ultrasound features and preoperative accuracy of the fine needle aspiration biopsy in detection of thyroid carcinomas

Ultrasound features and preoperative accuracy of the fine needle aspiration biopsy in detection of thyroid carcinomas

Clinical and Ultrasonographic Features of Papillary Thyroid Carcinoma Located in the Isthmus

Value of differential diagnosis of contrast‑enhanced ultrasound in benign and malignant thyroid nodules with microcalcification

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