Ultrasonographic findings in spontaneous miscarriage: relation to euploidy and aneuploidy

Ljunger, Elisabeth; Stavréus-Evers, Anneli; Cnattingius, Sven; Ekbom, Anders; Lundin, Catarina; Annerén, Göran; Sundström‐Poromaa, Inger

doi:10.1016/j.fertnstert.2010.06.018

Cited by 14 publications

(15 citation statements)

References 19 publications

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“…Goldstein et al and Coulam et al reported that ultrasound findings should not be used to predict the karyotypes associated with spontaneous miscarriages [16,17]. However, recent studies have demonstrated correlations between ultrasound findings and chromosomal anomalies [18,19]. Therefore, the objective of this study was to investigate the correlation between ultrasound findings and abnormal karyotypes associated with EPL after in vitro fertilization-embryo transfer (IVF-ET) based on the largest sample from a single reproductive center to date.…”

Section: Advanced Maternal Age (Ma) Is Associated With An Increasedmentioning

confidence: 98%

Correlation analysis between ultrasound findings and abnormal karyotypes in the embryos from early pregnancy loss after in vitro fertilization-embryo transfer

Ouyang

et al. 2016

J Assist Reprod Genet

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Purpose The purpose of the study is to evaluate the correlation between ultrasound findings and abnormal karyotypes in early pregnancy losses (EPLs) after in vitro fertilizationembryo transfer (IVF-ET). Methods This retrospective analysis assessed 2172 cases of EPL after IVF-ET occurring between January 2008 and December 2013. The cases were examined via transvaginal ultrasonography (TVS). Embryonic tissue karyotyping following miscarriage was performed using a comparative genomic hybridization (CGH) analysis with fluorescence in situ hybridization (FISH). The correlations between the ultrasound findings and the karyotypes were evaluated. Results Six categories of ultrasound findings were observed: normal ultrasound, empty sac, yolk sac only, small gestational sac, small embryonic pole, and early symmetrical arrested growth. The overall rate of abnormal karyotypes was 44.9 % (976/2172), and the rate of abnormal karyotypes associated with a normal ultrasound, empty sac, yolk sac only, small gestational sac, small embryonic pole, and early symmetrical arrested growth was 49.5 % (218/440), 28.1 % (138/491), 43.4 % (197/454), 50.0 % (43/86), 49.8 % (155/311), and 57.7 % (225/390), respectively. Compared with the other groups, the prevalence of chromosomal abnormalities was significantly higher in the early symmetrical arrested growth group but was markedly lower in the empty sac group in all cases and when cases of 46,XX were excluded (p < 0.05). Trisomy 16 was the most common chromosomal abnormality in the yolk sac only, small embryonic pole and early symmetrical arrested growth groups. In the empty sac, small gestational sac and normal ultrasound groups, monosomy X was the most frequent abnormality. Conclusions Chromosomal anomalies may be associated with specific types of ultrasound findings in EPLs after IVF-ET.

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Section: Advanced Maternal Age (Ma) Is Associated With An Increasedmentioning

confidence: 98%

Correlation analysis between ultrasound findings and abnormal karyotypes in the embryos from early pregnancy loss after in vitro fertilization-embryo transfer

Ouyang

et al. 2016

J Assist Reprod Genet

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“…Ethics approval was obtained from the Ethics Committee of our hospital (No. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42].…”

Section: Study Populationmentioning

confidence: 99%

“…19,20 Conversely, there have been a few reports that showed an association between an abnormal karyotype and US findings in the gestational sac, [21][22][23] yolk sac, 21,24 and embryo or fetus. 21,22,[24][25][26][27][28][29][30][31] However, to our knowledge, no studies have investigated whether there is a correlation between an abnormal fetal karyotype and US findings by a multivariate analysis on the basis of each structure, such as the gestational sac, yolk sac, and embryo. In this study, we comprehensively investigated what structural or US morphologic findings (gestational sac, yolk sac, and embryo) were most effective for estimating an abnormal fetal karyotype in early miscarriages before 12 weeks' gestation, including clinical characteristics.…”

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confidence: 99%

A Yolk Sac Larger Than 5 mm Suggests an Abnormal Fetal Karyotype, Whereas an Absent Embryo Indicates a Normal Fetal Karyotype

Yoneda

Shiozaki

Yoneda

et al. 2017

J of Ultrasound Medicine

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“…Chromosomal aberrations have been found in 60–80%, with most of the remaining cases being anembryonic amniotic sacs or fetuses with serious malformations. Fetuses that are both cytogenetically and morphologically normal are found in at most 7% of all miscarriages .…”

Section: Clinical Aspectsmentioning

confidence: 99%

Is recurrent miscarriage a useful clinical concept?

Vlaanderen¹

2014

Acta Obstet Gynecol Scand

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Many treatments have been used to increase the chances of an ongoing pregnancy after recurrent miscarriage (RM). Yet no clear evidence for an effective intervention has been found. Therefore, the clinical concept RM should be reconsidered. Both the statistical and clinical bases for RM are poor. If the individual risk is taken into account, then simple calculations explain the observed frequency of RM. Most miscarriages, either sporadic or recurrent, are abnormal in construction or development. Although some risk factors for miscarriage have been identified, such as age and number of previous miscarriages, the importance of other factors remains uncertain. RM has a favorable prognosis: the cumulative live birth rate is usually over 90% after two or three more attempts. So maternal systemic pathology does not seem to play a major role in the cause of RM. Little benefit can be expected from any intervention aimed at increasing the chance of a live birth. RM does not appear to be a real pathological entity that requires a special explanation. Moral support should replace medical interventions in most cases.

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Ultrasonographic findings in spontaneous miscarriage: relation to euploidy and aneuploidy

Cited by 14 publications

References 19 publications

Correlation analysis between ultrasound findings and abnormal karyotypes in the embryos from early pregnancy loss after in vitro fertilization-embryo transfer

Correlation analysis between ultrasound findings and abnormal karyotypes in the embryos from early pregnancy loss after in vitro fertilization-embryo transfer

A Yolk Sac Larger Than 5 mm Suggests an Abnormal Fetal Karyotype, Whereas an Absent Embryo Indicates a Normal Fetal Karyotype

Is recurrent miscarriage a useful clinical concept?

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