Ultrasonographic imaging of papillary thyroid carcinoma variants

Shin, Jung Hee

doi:10.14366/usg.16048

Cited by 36 publications

(66 citation statements)

References 47 publications

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“…Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with an indolent clinical course and a favorable prognosis ( 1 , 2 ). Several PTC subtypes exhibiting a combination of specific growth patterns, cell types, stromal changes, and nuclear features have been documented ( 3 ). In the revised American Thyroid Association guidelines ( 4 ), PTC is classified into three major subtypes according to the biological behavior: subtypes associated with aggressive outcomes, including the tall cell, columnar cell, and hobnail variants; subtype associated with less favorable outcomes, including the solid and diffuse sclerosing variants; and subtype associated with favorable outcomes, including the follicular, cribriform–morular, and Warthin-like variants.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes

et al. 2018

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BackgroundThe ultrasonographic characteristics and difference for various subtypes of papillary thyroid carcinoma (PTC) are still unclear. The aim of this study was to compare the ultrasonographic features of PTC according to its subtype in patients undergoing thyroid surgery.MethodsIn total, 140 patients who underwent preoperative thyroid ultrasonography (US) and thyroid surgery between January 2016 and December 2016 were included. The ultrasonographic features and the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) category of each thyroid nodule were retrospectively evaluated by a single radiologist, and differences in ultrasonographic features according to the PTC subtype were assessed.ResultsAccording to histopathological analyses, there were 97 classic PTCs (62.2%), 34 follicular variants (21.8%), 5 tall cell variants (3.2%), 2 oncocytic variants (1.3%), 1 Warthin-like variant (0.6%), and 1 diffuse sclerosing variant (0.6%). Most PTCs were classified under K-TIRADS category 5. Among the ultrasonographic features, the nodule margin and the presence of calcification were significantly different among the PTC subtypes. A spiculated/microlobulated margin was the most common type of margin, regardless of the PTC subtype. In particular, all tall cell variants exhibited a spiculated/microlobulated margin. The classic PTC group exhibited the highest prevalence of intranodular calcification, with microcalcification being the most common. The prevalence of multiplicity and nodal metastasis was high in the tall cell variant group.ConclusionThe majority of PTCs in the present study belonged to K-TIRADS category 5, regardless of the subtype. Our findings suggest that ultrasonographic features are not useful for distinguishing PTC subtypes.

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Section: Introductionmentioning

confidence: 99%

Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes

et al. 2018

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“…Our study demonstrates that the use of TI-RADS reduces the number of unnecessary biopsies and has the benefit of minimizing the burden on patients. The use of a relatively large cutoff size for biopsy of low-suspicion or mildly suspicious nodules is justified because the incidence of aggressive thyroid cancers as well as the malignancy risk is relatively low in these nodules (1,2).…”

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confidence: 99%

Dentate Nucleus Signal Intensity Decrease on T1-weighted MR Images after Switching from Gadopentetate Dimeglumine to Gadobutrol

Behzadi¹,

Farooq²,

Zhao³

et al. 2018

Radiology

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“…Several studies reported that, prognosis of patients with PTCs may be associated with both clinical features and pathological variants [13][14][15]. However, US characters of various PTC subgroups are still insufficient [15,16], even though the method was widely used as the primary method in evaluating thyroid lesions.…”

Section: Discussionmentioning

confidence: 99%

Clinical and sonographic characteristics of Warthin-like variant papillary thyroid carcinomas

et al. 2019

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Aim: To summarize the clinical, ultrasonographic (US) and pathological characteristics of Warthin-like variant papillary thyroid carcinomas (WVPTC).Material and methods: Medical records and US images of 32 cases of WVPTCs diagnosed between December, 2006 and September, 2018 were reviewed. Clinical, pathological and US characteristics of these cases were collected and summarized. ACR TI-RADS was followed during the analysis of the US features of the lesions. Results: Totally, 32 patients with 33 WVPTC nodules were reviewed. WVPTC was more often seen in female patients (27/32,84.4%) with a relatively high age (mean age, 51.0±10.8 years old). Hyperthyroidism was observed in 14 patients; 2 patients were diagnosed as subclinical hyperthyroidism and 1 patient as subclinical hypothyroidism. Abnormal thyroglobulin antibody was detected in 22 patients. Mean size of the nodule was 1.2±0.5 cm (range, 0.5~2.99 cm) on US. Pathologically, tumor margin of 63.6% carcinomas were infiltrative but most (72.9%) of the enrolled carcinomas were intra-thyroidal. Lymphocytic thyroiditis was detected in 87.5% (28/32) patients. On US, most WVPTCs were solid or almost complete solid (32/33, 97.0%) and very hypoechoic (26/33, 78.8%). Taller-than-wide shape (6/33, 18.2%) and punctate echogenic foci (9/33, 27.3%) were not popular. All the nodules were scored higher than 5 points according to the ACR TI-RADS, including 9 nodules that were classified into TR4 and 24 nodules as TR5. Follow-up information was available in 31 patients and no recurrence or distal metastasis was detected.Conclusions: WVPTC is a rare variant of PTCs with favorable outcomes. Very hypoechoic echogenicity, solid or almost complete solid composition are the vital indicators for biopsy, even though the nodule may be wider-than-tall and have a lack of punctuate echoic foci.

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Ultrasonographic imaging of papillary thyroid carcinoma variants

Cited by 36 publications

References 47 publications

Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes

Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes

Dentate Nucleus Signal Intensity Decrease on T1-weighted MR Images after Switching from Gadopentetate Dimeglumine to Gadobutrol

Clinical and sonographic characteristics of Warthin-like variant papillary thyroid carcinomas

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