Ultrasonographic measurement of the posterior coats of the eye and their relation to axial length

Guthoff, Rudolf; Berger, R. W.; Draeger, J.

doi:10.1007/bf02153409

Cited by 18 publications

(7 citation statements)

References 6 publications

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“…Nemeth et al 10 and Guthoff et al 38 reported similar findings in their studies after measuring the thickness of the "posterior ocular coat" (i.e., retina through sclera without measurement of the choroid separately) using ultrasonography. This technique measured the thickness from the retina to the sclera rather than the choroid alone.…”

Section: Discussionmentioning

confidence: 61%

See 1 more Smart Citation

Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography

Mwanza

Hochberg

Banitt

et al. 2011

Invest. Ophthalmol. Vis. Sci.

147

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Section: Discussionmentioning

confidence: 61%

“…There were 53 men and 61 women, and 60 right and 54 left eyes. Distribution by ethnic origin was as follows: 38 …”

Section: Demographic and Clinical Characteristics Of Subjectsmentioning

confidence: 99%

Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography

Mwanza

Hochberg

Banitt

et al. 2011

Invest. Ophthalmol. Vis. Sci.

147

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show abstract

“…Other measurements with scanning laser Doppler flowmeter showed a reduced retinal microcirculation in myopic and glaucomatous eyes [31]. Guthoff et al and Németh et al showed that in healthy persons the thickness of the ocular wall is very closely dependent on the axial length of the eye, and that the volume of the wall of the eye is nearly constant [32]. Choroidal thickness may probably not be an absolute indicator for failure or success of treatment for endophthalmitis, but decreased choroidal thickness can explain unexpected clinical outcomes with poor vision.…”

Section: Discussionmentioning

confidence: 99%

Spectral domain optical coherence tomography in patients after successful management of postoperative endophthalmitis following cataract surgery by pars plana vitrectomy

et al. 2014

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BackgroundAcute severe postoperative endophthalmitis may lead to severe vision loss. The aim of this study was the analysis of macular microstructure imaged by spectral domain optical coherence tomography in patients after pars plana vitrectomy due to postcataract endophthalmitis.MethodsA cross sectional study was carried out in 17 patients who had cataract surgery in both eyes and underwent unilateral pars plana vitrectomy due to postcataract endophthalmitis. Postoperative best corrected visual acuity was determined in both eyes. Evaluation of macular thickness, macular volume, peripapillary retinal nerve fiber layer thickness and choroidal thickness using enhanced depth imaging technique was performed by spectral domain optical coherence tomography. The measurements obtained in the operated eye were compared to the fellow eye by Wilcoxon matched pair test. Correlation test was performed by Spearman rank order.ResultsA mean postoperative best corrected visual acuity of 63 ± 30 ETDRS letters versus 75 ± 21 letters was achieved in the study and fellow eyes, respectively, after a mean of 5.3 ± 4.5 months (p = 0.1). The mean macular thickness was 320.6 ± 28.8 μm SD in the study eyes compared to 318.4 ± 18.8 μm in the fellow eyes (p = 0.767). No differences were noted in macular volume (p = 0.97) and in peripapillary retinal nerve fiber layer thickness (p = 0.31). Choroidal thickness was significantly lower in the study eyes compared to the fellow eyes (p = 0.018). Epiretinal membrane was found in 7 eyes after endophthalmitis, while in the fellow eyes only in 3 cases (p = 0.13, Fisher’s exact test).ConclusionChoroidal thickness decreased significantly after endophthalmitis, but there was no functional correlation with the changes in choroidal microstructure. The development of epiretinal membranes may be associated with either vitrectomy or endophthalmitis in the history. Absence of other significant structural and morphological findings shows that successful treatment may guarantee good clinical results even in long term after this severe postoperative complication.

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“…Guthoff et al . measured axial length and thickness of the posterior ocular coats ultrasonographically, including the choroid, in 159 eyes with a spherical correction varying from +14.0 to −27.0 diopters 31 . They found a constant tissue volume regardless of the difference in axial length between hyperopic and myopic eyes, suggesting that choroidal thinning in myopia was a function of axial elongation and passive stretch.…”

Section: Discussionmentioning

confidence: 99%

Correlation of axial length and myopic macular degeneration to levels of molecular factors in the aqueous

Wong¹,

Yanagi²,

Tsai³

et al. 2019

Sci Rep

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To elucidate the molecular processes associated with the development of myopic macular degeneration (MMD), we measured the intraocular concentrations of molecular factors in emmetropic and myopic eyes. This is a retrospective clinic-based case-control study that included eyes undergoing routine cataract surgery whereby aqueous humour samples were obtained. We measured the concentrations of pigment epithelium derived factor(PEDF), matrix metalloproteinase 2(MMP-2), tissue inhibitor of metalloproteinase(TIMP-2), vascular endothelial growth factor isoform A(VEGF-A), interleukin 8(IL-8), interleukin 6(IL-6), C-reactive protein(CRP), angiopoietin 2(Ang2), and amphiregulin. 38 eyes (axial length (AL): 22.4–32.4 mm), including 12 highly myopic (HM) eyes (AL ≥ 26.5 mm) without MMD and 12 HM eyes with MMD but without neovascularization were included. Eyes with MMD were found to have significantly lower VEGF-A levels (p = 0.007) and higher MMP-2 levels (p = 0.02) than control eyes after adjusting for age and gender. MMP-2 levels correlated positively (r = 0.58, p = 0.002), while VEGF-A levels correlated negatively with longer axial length (r = −0.75, p < 0.001). Both the concentrations of VEGF-A (P = 0.25) and MMP-2 (P = 0.69) were not significantly associated with MMD after adjusting for AL. These findings suggest that the predominant mechanism underlying the development of non-neovascular MMD may be axial elongation, driven in part by MMP-2 related mechanisms.

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Ultrasonographic measurement of the posterior coats of the eye and their relation to axial length

Cited by 18 publications

References 6 publications

Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography

Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography

Spectral domain optical coherence tomography in patients after successful management of postoperative endophthalmitis following cataract surgery by pars plana vitrectomy

Correlation of axial length and myopic macular degeneration to levels of molecular factors in the aqueous

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