Ultrasonography and ultrasound-guided fine-needle aspiration biopsy can predict a heavy nodal metastatic burden in early-stage breast cancer

Ahn, Hye Shin; Kim, Sun Mi; Jang, Mijung; Yun, Bo La; Kang, Eunyoung; Kim, Eun‐Kyu; Park, So Yeon; Kim, Bohyoung

doi:10.14366/usg.20143

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…And this agreed with the results reported by Kim et al (2015), who studied 201 thyroid nodules and found that the presence of coarse calcifications did not influence the RFA outcome at 6 or 12 months (P 0.68 and 0.94 respectively); no difference was found in nodule's reduction after RFA. Our results also were in agreement with results reported by Ahn et al (2021), which included A total of 22 benign thyroid nodules from 19 patients treated with RF ablation between March 2010 and January 2013 which found that calcifications were not significantly correlated with VRR (P>0.05).…”

Section: Discussionsupporting

confidence: 93%

“…He found that the median basal volume was 20.7 mL, and this significantly decreased after RFA at 6 months (7.3 mL (−63.5%) and at 12 months (6 mL (−70%), P vs 6 months = 0.009). Another study done by Ahn et al (2021), which included A total of 22 benign thyroid nodules from 19 patients treated with RF ablation between March 2010 and January 2013. The internal and external factors of these nodules were retrospectively reviewed and correlated with the therapeutic success and the volume reduction ratio (VRR).…”

Section: Discussionmentioning

confidence: 99%

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The role of radiofrequency ablation as an alternative tool in management of symptomatic benign thyroid nodules

Ahmad

Amer

Baky

et al. 2022

ijhs

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Aim of the work: To assess the role of radiofrequency ablation as an alternative tool in management of symptomatic benign thyroid nodules. Methods: We assessed non-functioning benign thyroid nodules in 10 patients, after treatment by radiofrequency (RF) ablation and follow-up for 6 months. RF ablation was done by Cool-Tip RF system and cooled internal electrode. Nodule volume, cosmetic and symptom scores were calculated earlier prior to treatment and throughout the follow-up. We assessed all efficacy related factors and reported complications. Results: A statistically significant difference existed between volume of nodules before the procedure with mean volume was 22.20 ± 4.61 and 1 month after with mean volume 12.38 ± 2.91with mean reduction ratio of 44.27 ± 5.77% and 3 months after the procedure with mean volume 8.08 ± 2.92 with mean reduction ratio of 65.14 ± 8.92%, also 6 months after procedure with mean volume 6.90 ± 2.78 with mean reduction ratio of 71.10 ± 7.71 %. The symptoms were significantly improved after RF ablation of patients complaining of compressive and cosmetic problems.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The role of radiofrequency ablation as an alternative tool in management of symptomatic benign thyroid nodules

Ahmad

Amer

Baky

et al. 2022

ijhs

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“…Moreover, the sensitivity and specificity of ABUS in predicting heavy nodal metastases were statistically similar to those of HHUS and those previously reported [ 17 24 ]. Among the diagnostic performance metrics, the NPV of ABUS was the highest, similar to that of HHUS and comparable to that previously reported (93%) by Luo et al [ 25 ].…”

Section: Discussionsupporting

confidence: 87%

“…Reviewers first evaluated the presence of identifiable benign-looking or suspicious axillary LNs on ABUS images and then evaluated the LNs based on the following findings: hilum compression or loss, uneven or even cortical thickening > 3-mm, focal hyperechoic cortical change, LN shape (oval, round, or irregular), circumscribed or non-circumscribed LN margins, and presence of extranodal extension [ 16 ]. Any of the following US findings were considered abnormal: hilum compression or loss, > 3-mm uneven cortical thickening, > 3-mm cortical thickening, focal hyperechoic cortical change, round or irregular shape, non-circumscribed margin, and extranodal extension of axillary LNs [ 16 17 ].…”

Section: Methodsmentioning

confidence: 99%

Automated Versus Handheld Breast Ultrasound for Evaluating Axillary Lymph Nodes in Patients With Breast Cancer

Kim,

Jang,

Yun

et al. 2024

Korean J Radiol

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Objective Automated breast ultrasound (ABUS) is a relevant imaging technique for early breast cancer diagnosis and is increasingly being used as a supplementary tool for mammography. This study compared the performance of ABUS and handheld ultrasound (HHUS) in detecting and characterizing the axillary lymph nodes (LNs) in patients with breast cancer. Materials and Methods We retrospectively reviewed the medical records of women with recently diagnosed early breast cancer (≤ T2) who underwent both ABUS and HHUS examinations for axilla (September 2017–May 2018). ABUS and HHUS findings were compared using pathological outcomes as reference standards. Diagnostic performance in predicting any axillary LN metastasis and heavy nodal-burden metastases (i.e., ≥ 3 LNs) was evaluated. The ABUS-HHUS agreement for visibility and US findings was calculated. Results The study included 377 women (53.1 ± 11.1 years). Among 385 breast cancers in 377 patients, 101 had axillary LN metastases and 30 had heavy nodal burden metastases. ABUS identified benign-looking or suspicious axillary LNs (average, 1.4 ± 0.8) in 246 axillae (63.9%, 246/385). According to the per-breast analysis, the sensitivity, specificity, positive and negative predictive values, and accuracy of ABUS in predicting axillary LN metastases were 43.6% (44/101), 95.1% (270/284), 75.9% (44/58), 82.6% (270/327), and 81.6% (314/385), respectively. The corresponding results for HHUS were 41.6% (42/101), 95.1% (270/284), 75.0% (42/56), 82.1% (270/329), and 81.0% (312/385), respectively, which were not significantly different from those of ABUS ( P ≥ 0.53). The performance results for heavy nodal-burden metastases were 70.0% (21/30), 89.6% (318/355), 36.2% (21/58), 97.3% (318/327), and 88.1% (339/385), respectively, for ABUS and 66.7% (20/30), 89.9% (319/355), 35.7% (20/56), 97.0% (319/329), and 88.1% (339/385), respectively, for HHUS, also not showing significant difference ( P ≥ 0.57). The ABUS–HHUS agreement was 95.9% (236/246; Cohen’s kappa = 0.883). Conclusion Although ABUS showed limited sensitivity in diagnosing axillary LN metastasis in early breast cancer, it was still useful as the performance was comparable to that of HHUS.

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“…AUS is recommended during the clinical work-up and staging of newly diagnosed breast cancer to predict the axillary metastatic tumor burden which in turn guides clinical management of the axilla and helps to triage patients for preoperative systemic therapy [16] , [17] , [18] , [19] . Our observation of cortical thickness ≥ 5.4 mm as well as displacement or loss of the hilum are AUS features predictive of malignancy, consistent with the findings of other investigators [20] , [21] .…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Features to Differentiate COVID-19 Vaccine-Induced Benign Adenopathy from Breast Cancer Related Malignant Adenopathy

Chung

et al. 2022

Academic Radiology

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Ultrasonography and ultrasound-guided fine-needle aspiration biopsy can predict a heavy nodal metastatic burden in early-stage breast cancer

Abstract: Ultrasound and ultrasound-guided fine needle aspiration biopsy can predict heavy nodal metastatic burden in early-stage breast cancer

Cited by 3 publications

References 23 publications

The role of radiofrequency ablation as an alternative tool in management of symptomatic benign thyroid nodules

The role of radiofrequency ablation as an alternative tool in management of symptomatic benign thyroid nodules

Automated Versus Handheld Breast Ultrasound for Evaluating Axillary Lymph Nodes in Patients With Breast Cancer

Ultrasound Features to Differentiate COVID-19 Vaccine-Induced Benign Adenopathy from Breast Cancer Related Malignant Adenopathy

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