Ultrasonography for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism: comparison with ^99mtechnetium sestamibi scintigraphy

Abstract

Ultrasonography can be a sensitive and accurate method for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism, comparable in overall utility to sestamibi scintigraphy. These results suggest that a strategy of initial testing with one or the other method, followed by the alternate imaging test if the first test is negative, would provide correct parathyroid imaging in most patients without prior parathyroid surgery.

Mediastinal Parathyroid Adenoma Mimicking Cancer Metastatic to Bone

“…Commonly used modalities include ultrasound, CT or magnetic resonance imaging, and technetium sestamibi scintigraphy. Ultrasound is commonly used due to its low cost and convenience, but it has poor sensitivity (≤30%) for locating ectopic glands (14). Even the sensitivity for localization of enlarged parathyroid glands in the normal anatomical location varies greatly (44 to 87%) and depends on operator skill and experience (14).…”

“…Ultrasound is commonly used due to its low cost and convenience, but it has poor sensitivity (≤30%) for locating ectopic glands (14). Even the sensitivity for localization of enlarged parathyroid glands in the normal anatomical location varies greatly (44 to 87%) and depends on operator skill and experience (14). In comparison, parathyroid scintigraphy and CT imaging have a much higher sensitivity than ultrasound for localizing parathyroid adenoma (71 to 93% and 76 to 83%, respectively) (14) and the sensitivity can be up to 100% when parathyroid scintigraphy and CT imaging are used in combination (15).…”

Comparison of laboratory and imaging methods associated with bone metabolism in patients with or without renal failure under the age of 45 years with elevated parathyroid hormone levels

“…Although dual-phase dual-isotope iodine 123 ( 123 I)/technetium Tc 99m ( 99 mTc) sestamibi scintigraphy and ultrasonography and their comparison for determination of enlarged parathyroid glands in primary hyperparathyroidism has been discussed in many studies, their utility in renal hyperparathyroidism is rarely addressed [29,30]. Périé et al [31] reported that a series of 20 patients consecutively referred for parathyroidectomy, hyperplastic parathyroid glands were detected by USG in 75%, dual-phase 123 I/ 99 mTc sestamibi scintigraphy in 66%, and both methods in 88%.…”

Hiperparatireoidismo primário familiar isolado: análise e descrição de uma família com seis casos índices

“…As hiperplasias glandulares podem não ser identificadas ao ultrassom e cintilografia, sendo importante, neste caso, a exploração de todas as glândulas durante o ato cirúr-gico (25). Os dois métodos em conjunto auxiliam na localização de glândulas ectópicas (27,28). Conforme observado em nossos casos, o ultrassom, nos cinco pacientes que o realizaram, foi conclusivo e compatível com os achados pós-operatórios, estando nestes a cintilografia negativa.…”