Ultrasonography-Guided Fine-Needle Aspiration for the Assessment of Cervical Metastases

Knappe, M. V.; Louw, Mercia; Gregor, R. T.

doi:10.1001/archotol.126.9.1091

Cited by 131 publications

(78 citation statements)

References 23 publications

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“…Its sensitivity for the clinically N 0 neck has been reported to be as high as 73% and to have a specificity of 100% (34), although others have reported sensitivities in the 42-50% range (35)(36)(37). A combination of sentinel node lymphoscintigraphy and ultrasound-guided fine-needle aspiration cytology has been reported, but adding sentinel lymphoscintigraphy did not improve the results (31).…”

Section: Discussionmentioning

confidence: 99%

Predictive Markers for Late Cervical Metastasis in Stage I and II Invasive Squamous Cell Carcinoma of the Oral Tongue

Lim

Zhang

Ishii

et al. 2004

Clinical Cancer Research

241

200

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Purpose: Patients with oral tongue carcinoma treated by intraoral excision only should be followed up carefully for cervical lymph node metastasis and salvaged immediately if found, because some patients have a more aggressive clinical course. The purpose of this study was to find useful markers for predicting late cervical metastasis in patients with stage I and II invasive squamous cell carcinoma of the oral tongue.Experimental Design: We investigated clinicopathologic factors and immunohistochemical biomarkers predicting late cervical metastasis in surgical specimens from 56 patients with T 1-2 N 0 M 0 invasive squamous cell carcinoma of the oral tongue who did not undergo elective neck dissection. Histopathologic factors including tumor thickness, mode of invasion, Broders grade, total score of three different malignancy grading systems, eight other clinicopathologic parameters, and immunohistochemical expression of p53, cyclin D1, Ki-67, epidermal growth factor receptor, microvessel density, cyclooxygenase-2, MUC1, laminin-5 ␥2, E-cadherin, and ␤-catenin were examined. All of the clinicopathologic factors and immunohistochemical expression of biomarkers were compared in terms of survival.Results: In the univariate analysis, tumor thickness (P ‫؍‬ 0.009), Broders grade (P ‫؍‬ 0.017), nest shape (P ‫؍‬ 0.005), mode of invasion (P < 0.001), Anneroth score (P ‫؍‬ 0.029), Bryne score (P < 0.001), and E-cadherin expression (P ‫؍‬ 0.003) were correlated with late cervical metastasis. Multivariate analysis on late cervical metastasis revealed that tumor thickness >4 mm, mode of invasion grade 3 or 4, and E-cadherin expression were independent factors. Late cervical metastasis was the only prognostic factor for overall survival (P ‫؍‬ 0.002).Conclusions: Our results indicate that patients with stage I and II invasive squamous cell carcinoma of the oral tongue with tumor thickness >4 mm, mode of invasion grade 3 or 4, and low expression of E-cadherin should be considered a high-risk group for late cervical metastasis when a wait-and-see policy for the neck is adopted.

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Section: Discussionmentioning

confidence: 99%

Predictive Markers for Late Cervical Metastasis in Stage I and II Invasive Squamous Cell Carcinoma of the Oral Tongue

Lim

Zhang

Ishii

et al. 2004

Clinical Cancer Research

241

200

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“…For the purpose of calculating the sensitivity of the proposed histological categories, we considered as falsenegative any inadequate/non-diagnostic FNABcytology or negative FNAB-Tg in histologically proven metastatic lymph nodes (8,18,19). As shown in Table 2, the FNAB-Tg sensitivity in metastatic lymph nodes and in cystic metastatic lymph nodes was 100% in both.…”

Section: Patients Awaiting Thyroidectomymentioning

confidence: 99%

“…With the results presented in Table 1, it was possible to compare FNAB-cytology and FNAB-Tg with the histological report (gold standard) and also to determine the sensitivity and specificity of the tests. On this basis, we considered true positive any suspicious FNABcytology or positive FNAB-Tg and false-negative any inadequate/non-diagnostic FNAB-cytology (8,18,19) or negative FNAB-Tg in histologically proven metastatic lymph nodes.…”

Section: Thyroidectomised Patients Under Follow-upmentioning

confidence: 99%

Thyroglobulin detection in fine-needle aspirates of cervical lymph nodes: a technique for the diagnosis of metastatic differentiated thyroid cancer

et al. 2007

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Background: Fine-needle aspiration cytology is frequently used for differential diagnosis of neck masses of unknown origin. Inconclusive and even false-negative results are not uncommon. Aim: To evaluate the utility of thyroglobulin (Tg) measurement in fine-needle aspirates (FNA-Tg) for detecting cervical lymph node (CLNs) metastases from differentiated thyroid carcinomas. Methods: An ultrasound-guided fine-needle aspiration was done in 67 patients with 83 suspicious enlarged CLNs to obtain material for cytology and Tg measurement in the needle washout, using an immunometric chemiluminescent assay. Measurement of anti-Tg antibodies (FNA-TgAb) was also carried out in half of all the aspirates. Subjects were divided into two groups: one of 16 patients awaiting thyroidectomy and the other of 51 patients in follow-up after surgery. Results: The first group of patients had positive FNA biopsy (FNAB-Tg) in 14 out of the 18 studied CLNs with a range of 3.2-43 352 ng/ml, while FNAB-cytology indicated metastasis in only 8 out of the 14 CLNs with positive histology. A total of 65 CLNs were studied in the follow-up group. Lymphadenectomy was performed in 23 patients and 28 aspirated CLNs were removed. Histology confirmed the diagnosis of metastasis suggested by FNAB-Tg in 20 CLNs and of reactive lymphadenitis in the remaining 8 CLNs. FNAB-cytology was positive in only 11 CLNs. Sensitivity of FNAB-Tg was not affected by the studied FNAB-TgAb. Conclusions: The FNAB-Tg achieved a sensitivity of 100% in both groups. FNAB-Tg is an easy and inexpensive technique which proved to increase the diagnostic of cytology in the early diagnosis of papillary carcinoma recurrence to CLN even in the presence of serum TgAb.

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“…US detected several abnormalities in active lesions including decreased blood flow, increased echogenicity and loss of subcutaneous fat and reduction in lesion size during treatment. 19 Hesselstrand et al used high frequency ultrasonography for assessment of systemic sclerosis. 20 …”

Section: Us In Oral Submucous Fibrosis (Osmf)mentioning

confidence: 99%

Ultrasonography; A boon as a diagnostic & therapeutic aid in dentistry: A review

Dharti

Neerjesh

Wadhawan³

et al. 2014

Int J of Biomed & Adv Res

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Ultrasonography-Guided Fine-Needle Aspiration for the Assessment of Cervical Metastases

Cited by 131 publications

References 23 publications

Predictive Markers for Late Cervical Metastasis in Stage I and II Invasive Squamous Cell Carcinoma of the Oral Tongue

Predictive Markers for Late Cervical Metastasis in Stage I and II Invasive Squamous Cell Carcinoma of the Oral Tongue

Thyroglobulin detection in fine-needle aspirates of cervical lymph nodes: a technique for the diagnosis of metastatic differentiated thyroid cancer

Ultrasonography; A boon as a diagnostic & therapeutic aid in dentistry: A review

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