Objective. To evaluate morphologic features of bladder disorders in female lower urinary tract symptoms using ultrasonographic cystourethrography and to elucidate the anatomic association of these morphologic characteristics. Methods. Ultrasonographic cystourethrography was performed in 1049 women with lower urinary tract symptoms and 1 single urodynamic diagnosis, including 764 patients with genuine stress incontinence, 190 with detrusor instability, and 95 with a hypersensitive bladder. Thirty-six women with no lower urinary tract symptoms served as control subjects. Ultrasonographic assessment included measurement of the bladder neck position at rest and during stress and observation of the development of bladder neck funneling and cystocele during the Valsalva maneuver. Results. Hypersensitive bladder and control groups had a significantly higher bladder neck position at rest and during stress, a lesser rotational angle of the bladder neck, a lower prevalence of bladder neck funneling and cystocele formation, and lesser mean bladder wall thickness than the other diagnostic groups. In the study groups, age, parity, and menopause may have effects on the cystourethrographic parameters except rotational angle and funneling of the bladder neck. With control of the confounding factors, bladder wall thickness at the trigone and dome was negatively correlated with the resting bladder neck angle (P = .006 and 0.019, respectively). Bladder wall thickness at the dome was positively associated with the rotational angle of the bladder neck (P = .022). Funneling of the bladder neck and development of cystocele during stress were positively associated with the resting and straining bladder neck angles as well as the rotational angle of the bladder neck. Conclusions. Ultrasonographic manifestation of a hypersensitive bladder is significantly different from that of genuine stress incontinence and detrusor instability. Key words: lower urinary tract symptoms; ultrasonography; urodynamics. Abbreviations HB, hypersensitive bladder; DI, detrusor instability; GSI, genuine stress incontinence; LUTS, lower urinary tract symptoms emale lower urinary tract symptoms (LUTS) are present in a heterogeneous group of disorders with varied pathogenesis. Because urinary symptoms are diagnostically unreliable, 1 it is appropriate to use urodynamic investigation and imaging studies as an integral part of evaluation of lower urinary tract disorders. Currently, videocystourethrography is a tool that simultaneously offers both urodynamic and anatomic assessment of the lower urinary tract. However, it is not widely available because of its sophistication and concerns about radiation exposure. Ultrasonography, which is noninvasive, easily reproducible, and without radiation, has replaced radiologic methods in anatomic evaluation of the lower urinary tract. [2][3][4][5][6]