Ultrasound Aided Expedient Synthesis, Characterization and
Antimicrobial Studies of Fluorenyl-Hydrazono-Thiazole Derivatives

Kaur, Avneet; Gautam, Deepika

doi:10.14233/ajchem.2019.22118

“…The ultrasonication gave the target products in higher yields and purity in shorter reaction times compared with the conventional method. [36,37] The biological results indicated that only compounds 35 and 36 displayed moderate biological activity against Gram-positive and Gram-negative bacteria, while fluorenyl-hydrazonothiazoles 37-38 present interesting antifungal activities (Table 12). 39a-f and 40a-f) by employing a one-pot multi-component approach.…”

Section: Methodsmentioning

confidence: 99%

Frontiers in Anti-Infective Drug Discovery: Volume 9

2021

Frontiers in Anti-Infective Drug Discovery

0

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Antimicrobial resistance of Gram-negative bacteria is a major concern and no new classes of antibiotics that are effective against this type of bacteria have been discovered since the 1960s. During the last decades, multiple approaches have been developed to combat such a bacterial resistance. However, the combination of antibiotic resistance mechanisms by bacteria and the limited number of effective antibiotics available, decreases the number of the interventions for the treatment of current bacterial infections. The solution to emerging antibiotic resistance will likely involve new therapies or new classes of antibacterial agents. For a few years now, there was a real interest in the design and synthesis of hydrazones possessing an azometine -NHN=CH-proton and constituting an important class of compounds for new drugs development as anticonvulsants, antidepressants, antitumoral agents. In this context, the design and antimicrobial evaluation of hydrazone derivatives has constituted one of the new strategies developed to fight bacterial resistance. As pointed out the range of biological activities is very broad, and this review will deal exclusively with the synthesis and use of hydrazones as antimicrobial agents and will not cover the other biological properties already well depicted in literature. Thus, we will report herein the scope and limitation of such an approach providing numerous examples demonstrating structure-activity relationships and potent interesting antimicrobial activities against both fungi, Gram-positive and/or Gram-negative bacteria.

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Antimicrobial study of ruthenium and iridium half-sandwich complexes containing fluorenyl hydrazonothiazole derivative ligands

Sawkmie,

Banothu,

Kaminsky

et al. 2023

Journal of Coordination Chemistry

0

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Frontiers in Anti-Infective Drug Discovery Volume 6

2017

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Antimicrobial resistance of Gram-negative bacteria is a major concern and no new classes of antibiotics that are effective against this type of bacteria have been discovered since the 1960s. During the last decades, multiple approaches have been developed to combat such a bacterial resistance. However, the combination of antibiotic resistance mechanisms by bacteria and the limited number of effective antibiotics available, decreases the number of the interventions for the treatment of current bacterial infections. The solution to emerging antibiotic resistance will likely involve new therapies or new classes of antibacterial agents. For a few years now, there was a real interest in the design and synthesis of hydrazones possessing an azometine -NHN=CH-proton and constituting an important class of compounds for new drugs development as anticonvulsants, antidepressants, antitumoral agents. In this context, the design and antimicrobial evaluation of hydrazone derivatives has constituted one of the new strategies developed to fight bacterial resistance. As pointed out the range of biological activities is very broad, and this review will deal exclusively with the synthesis and use of hydrazones as antimicrobial agents and will not cover the other biological properties already well depicted in literature. Thus, we will report herein the scope and limitation of such an approach providing numerous examples demonstrating structure-activity relationships and potent interesting antimicrobial activities against both fungi, Gram-positive and/or Gram-negative bacteria.

show abstract

Ultrasound Aided Expedient Synthesis, Characterization and Antimicrobial Studies of Fluorenyl-Hydrazono-Thiazole Derivatives

Cited by 5 publications

References 15 publications

Frontiers in Anti-Infective Drug Discovery: Volume 9

Frontiers in Anti-Infective Drug Discovery: Volume 9

Antimicrobial study of ruthenium and iridium half-sandwich complexes containing fluorenyl hydrazonothiazole derivative ligands

Frontiers in Anti-Infective Drug Discovery Volume 6

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