Ultrasound and Computer Tomography in the Evaluation of Focal Liver Disease

Bartolozzi, Carlo; Ciatti, S; Lucarelli, Elisabetta; Villari, Natale; Dedominicis, R

doi:10.1177/028418518102200506

Cited by 16 publications

(7 citation statements)

References 14 publications

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“…It is of the utmost importance that a focal liver lesion is visualized with the greatest accuracy. Scintigraphy (Christensen, Jacobsen & Johansen 1982) has been used for that purpose, but CT scanning (Bartolozzi et al. 1981al.…”

Section: Discussionmentioning

confidence: 99%

“…Histological fine needle biopsy (HFNB) from the liver is a rather new diagnostic method that has the potential of providing the morphological benefits of surgical biopsies (Isler et al. 1981, Wittenberg et al 1982, Lieberman, Hafez & Crummy 1982, Wernecke, Heckemann & Rehwald 1984, Torp-Pedersen, Juul & Vyberg 1984.…”

Section: Introductionmentioning

confidence: 99%

“…Some authors have found that HFNB results in more accurate diagnoses than CFNB (Lieberman et , Torp-Pedersen et al 1984, Limberg, Hopker & Kommerell 1987, while others have reported that a higher diagnostic sensitivity with respect to malignancy using CFNB could be combined with a better ability to determine the site of a primary tumour with HFNB (Isler et a / . 1981, Wittenberg et a/. 1982, Tatsuta et al 1984, Bell, Carr & Szyfelbein 1986.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic reliability of histological and cytological fine needle biopsies from focal liver lesions

1989

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In 175 consecutive cases of ultrasonically detected focal liver lesions both cytological and histological fine needle biopsies were performed using two different 0.6 mm needles. The cytological and histological material was evaluated blindly and separately by two examiners, who had no access to clinical data. In 65 cases a reliable final diagnosis as defined by autopsy or surgical biopsy within 6 months could be reached. Eleven cases of benign liver lesions were correctly classified by the two examiners by both cytological and histological fine needle biopsies, resulting in a predictive value of 100% for a malignant diagnosis. The predictive value for a benign diagnosis was 85% for both examiners' evaluation of cytological fine needle biopsies, while it was 73% and 85%, respectively, for histological fine needle biopsies. At reevaluation both sampling error and difficulties in interpretation of biopsies of poor quality were responsible for the false benign diagnosis. The origin of the primary tumour was correctly diagnosed in about 50% of the cases by both techniques. Correct tumour typing could most often be made by both methods in cases of hepatocellular carcinoma, breast carcinoma, colonic carcinoma and small cell carcinoma of the lung.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic reliability of histological and cytological fine needle biopsies from focal liver lesions

1989

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“…18,19 More recent studies, with faster total body scan times of 18 seconds and less roentgenogram diffraction by using narrower window widths, have shown CT to be equal, or superior, to US and RN scans in evaluating hepatic neoplasms. [7][8][9][10] Cancer patients receiving hepatic resection or transplantation are an ideal population in which to study the accuracy of hepatic-imaging techniques. The imaging procedure in this setting is usually done shortly before the operative procedure.…”

Section: Discussionmentioning

confidence: 99%

“…6 In a comparative study of US and CT in the evaluation of focal liver disease, US was found to be more sensitive but CT had higher specificity and provided more information about intrahepatic masses and extrahepatic disease, if present. 7 Overall, when compared to either US or RN scans, CT is presently considered to be the single best examination to determine both the presence and the extent of space-occupying lesions within the liver. [8][9][10] CT scanning, therefore, has become an accepted method for defining tumor response to treatment.…”

mentioning

confidence: 99%

Accuracy of Computerized Tomography in Determining Hepatic Tumor Size in Patients Receiving Liver Transplantation or Resection

Mittal¹,

Kowal²,

Starzl³

et al. 1985

Journal of Computer Assisted Tomography

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Computerized tomography (CT) of liver is used in oncologic practice for staging tumors, evaluating response to treatment, and screening patients for hepatic resection. Because of the impact of CT liver scan on major treatment decisions, it is important to assess its accuracy. Patients undergoing liver transplantation or resection provide a unique opportunity to test the accuracy of hepatic-imaging techniques by comparison of findings of preoperative CT scan with those at gross pathologic examination of resected specimens. Forty-one patients who had partial hepatic resection (34 patients) or liver transplantation (eight patients) for malignant (30 patients) or benign (11 patients) tumors were evaluable. Eight (47%) of 17 patients with primary malignant liver tumors, four (31%) of 13 patients with metastatic liver tumors, and two (20%) of 10 patients with benign liver tumors had tumor nodules in resected specimens that were not apparent on preoperative CT studies. These nodules varied in size from 0.1 to 1.6 cm. While 11 of 14 of these nodules were <1.0 cm, three of 14 were >1.0 cm. These results suggest that conventional CT alone may be insufficient to accurately determine the presence or absence of liver metastases, extent of liver involvement, or response of hepatic metastases to treatment.

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Diagnostic value of high molecular weight alkaline phosphatase in detection of hepatic metastasis in patients with lung cancer

Nishio

Sakuma

Nakamura

et al. 1986

Cancer

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High molecular weight alkaline phosphatase (HMW-ALP) was measured in the sera of 126 patients with lung cancer to determine its diagnostic value in the detection of hepatic metastasis. This isoenzyme was found in 21 of 24 patients with hepatic metastasis and in 27 of 102 patients without hepatic metastasis. When 10 U/L was used as a cut-off value, the sensitivity, specificity, and accuracy of this test were 71%, 89%, and 86%, respectively. From the standpoint of histologic type, this test was most useful in patients with small cell carcinoma. HMW-ALP was not detected in the sera of 15 controls. It is concluded that HMW-ALP is a useful marker for hepatic metastasis in patients with lung cancer.

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Ultrasound and Computer Tomography in the Evaluation of Focal Liver Disease

Cited by 16 publications

References 14 publications

Diagnostic reliability of histological and cytological fine needle biopsies from focal liver lesions

Diagnostic reliability of histological and cytological fine needle biopsies from focal liver lesions

Accuracy of Computerized Tomography in Determining Hepatic Tumor Size in Patients Receiving Liver Transplantation or Resection

Diagnostic value of high molecular weight alkaline phosphatase in detection of hepatic metastasis in patients with lung cancer

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