Ultrasound and fetal diagnosis

Filkins, Karen; Koos, Brian J.

doi:10.1097/01.gco.0000162190.83972.5a

Cited by 24 publications

(13 citation statements)

References 105 publications

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“…It is widely accepted that severe categories of VM are associated with higher risks of poor clinical outcome, 12 and indeed recent studies have questioned whether mild VM (trigone measurements of 10 -12 mm) is truly abnormal if it is an isolated finding. 13,14 For example, in a study of 176 cases, Gaglioti et al 7 showed that a fetus with isolated VM had a 97.7% chance of being alive at 2 years if the VM was mild, an 80% chance with moderate VM, and a 33.3% chance with severe VM. Of those that were alive, neurodevelopmental outcome was normal in 93% of mild cases, 75% of moderate, and 62.5% of severe VM cases.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study of Fetuses with Isolated Ventriculomegaly Investigated by Antenatal Sonography and In Utero MR Imaging

Griffiths¹,

Reeves²,

Morris³

et al. 2009

AJNR Am J Neuroradiol

133

117

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BACKGROUND AND PURPOSE:Fetal ventriculomegaly (VM) is important because of its high prevalence and high risk of association with other brain abnormalities. The purpose of this article was to investigate the hypotheses that including in utero MR imaging (iuMR) in the diagnostic pathway for fetuses with isolated VM on antenatal imaging will show other brain abnormalities in a high proportion of cases and that these will have a significant effect on clinical management.

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Section: Discussionmentioning

confidence: 99%

A Prospective Study of Fetuses with Isolated Ventriculomegaly Investigated by Antenatal Sonography and In Utero MR Imaging

Griffiths¹,

Reeves²,

Morris³

et al. 2009

AJNR Am J Neuroradiol

133

117

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“…Other strategies have been proposed in several ways: sequential testing, in which the gravida elects, after knowing the primary results, to add new markers [30,31] (quadruple screening and/or second trimester ultrasound markers such as short humerus, short femur, hydroncphrosis, echogenic cardiac foci, echogenic bowel, uterine arter>', etc. ); and contingency testing [32], in which additional screening is only performed for an intermediate-risk group.…”

Section: Discussionmentioning

confidence: 99%

First trimester combined screening for chromosomal defects: Our results in a population with a high percent of women aged 35 or older

Montalvo

Gómez

Ortega

et al. 2005

The Ultrasound Review of Obstetrics & Gynecology

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Background. Screenitig strategies for the detccrion of aneuploidies should be performed by every Prenatal Diagnosis Ser\'ice. Several screening approaches have been developed, reaching detection rates of at least 85% for a 5% false-positive rate. Our experience in a population with a high percent of women aged 35 or older using combined screening is presented. Methods. From July 1999 to October 2004, we conducted a prospective study of screening for fetal aneuploidies among pregnant women between 10 and 14 weeks. Risks for aneuploidy were calculated by combined screening, using maternal age, maternal serum free-/JhCG, pregnancy-associated plasma protein-A (PAPP-A) and fetal nuchal translucency. The result was considered positive if the combined risk exceeded the cut off risk of 1/270. Results. Screening was completed in 4538 singleton pregnancies. The mean maternal age was 31.08 years, and in 25.9% the age was 35 years or greater. The detection rate was 76.9% (30/39) for all aneuploidies with a false-positive rate of 3,6%. For trisomy 21, the detection rate was I'i.l'Vu (14/19) with a false-positive rate of 3.6%. At a 5% false-positive rate, the sensitivity of combined screening and nuchal translucency were 78.9% and 63.2% respectively. Conclusiom. First trimester combined screening is efficient, and its application can be assumed in a tertiary-hospital.

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“…This allows for stratification of fetal distress to determine if and when intrauterine intervention is necessary. Doppler velocimetry, although not useful for identifying congenital heart defects, is helpful for the evaluation of fetal myocardial function (7). Venous velocimetry can be used to detect hydrops, an indicator of imminent demise due to high-output cardiac failure seen in arterio-venous shunts due to sacrococcygeal teratomas and other malformations (7).…”

Section: Imaging Modalitiesmentioning

confidence: 99%

Advances in fetal surgery

Maselli¹,

Badillo²

2016

Ann. Transl. Med.

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Historically, the gold standard for the treatment of congenital malformations has been planned delivery at tertiary care center with attempted post-natal repair or amelioration of the lesion. Over the last few decades however, rapid advances in imaging and instrumentation technology combined with superior knowledge of fetal pathophysiology has led to the development of novel intrauterine interventions for most common fetal anomalies.Great success has already been seen the treatment of previous devastating anomalies such as myelomeningocele (MMC), congenital cystic malformations of the lung, twin-twin transfusion, and sacrococcygeal teratomas.Although still limited, these innovative techniques have unique potential to improve outcomes in the most devastating fetal anomalies.

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Ultrasound and fetal diagnosis

Abstract: Imaging techniques have been critical in the development of screening methods for Down syndrome or trisomy 18 and for euploid fetuses at high risk for adverse outcomes.

Cited by 24 publications

References 105 publications

A Prospective Study of Fetuses with Isolated Ventriculomegaly Investigated by Antenatal Sonography and In Utero MR Imaging

A Prospective Study of Fetuses with Isolated Ventriculomegaly Investigated by Antenatal Sonography and In Utero MR Imaging

First trimester combined screening for chromosomal defects: Our results in a population with a high percent of women aged 35 or older

Advances in fetal surgery

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