Ultrasound and Histologic Examination after Subcutaneous Injection of Two Volumizing Hyaluronic Acid Fillers: A Preliminary Study

Micheels, Patrick; Besse, Stéphanie; Sarazin, Didier; Quinodoz, Pierre; Elias, Badwi; Safa, Marva; Vandeputte, Joan

doi:10.1097/gox.0000000000001222

Cited by 17 publications

(11 citation statements)

References 14 publications

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“…Accordingly, these fillers may be more appropriate for the correction of NLFs (Pierre, Liew, & Bernardin, ). Previous studies of monophasic fillers found that the B filler was more cohesive and better maintained over time than the J filler (Micheels et al, ). In their study, the present authors found that in terms of 3D changes in facial height, the B filler was superior to the Y filler.…”

Section: Discussionmentioning

confidence: 94%

Comparative split‐face study of durational changes in hyaluronic acid fillers for mid‐face volume augmentation

Park

Kim

Seok

et al. 2019

Dermatologic Therapy

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Subsequent changes after injection should be considered when determining the precise volume of injected dermal filler. Several studies have used scoring systems to evaluate facial volumes; however, these scoring systems are not particularly objective. This present study aimed to evaluate the volumetric changes over time on three‐dimensional (3D) images and the maintenance potential of various hyaluronic acid (HA) fillers used for mid‐face volume augmentation. This split‐face clinical study included nine Korean subjects who each received a mid‐facial injection of the test filler (B) on one side and a random control filler (J, R, or Y) on the contralateral side. Global, photographic, and 3D scanning assessments were conducted at baseline and after 30 min, 3 days, and 2, 4, 12, and 24 weeks. In all nine cases, the 3D images revealed the largest differences in height where the test filler (B) was injected. The results of subjective scoring systems correlated with the results of 3D imaging. The volumes of monophasic fillers (B and J) were maintained for longer periods of time than those of biphasic fillers (R and Y). The B filler yielded excellent volumizing and spreading effects and good injectability. This filler would be suitable for injection into high‐pressure areas, such as the lateral cheek, chin, and nasolabial fold. Moreover, the 3D imaging analysis provided objective and digitized data. The present authors hope that their data will allow physicians to better understand the durational changes in HA fillers and, thus, provide accurate predictions to their patients.

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Section: Discussionmentioning

confidence: 94%

Comparative split‐face study of durational changes in hyaluronic acid fillers for mid‐face volume augmentation

Park

Kim

Seok

et al. 2019

Dermatologic Therapy

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“…When the HA gel goes out of the needle, it is distributed into the skin tissues depending on the rheological properties and cohesivity of the gel and the specific physico-mechanical properties of the receiving tissues [4,13] . The cohesivity, defined as the capacity of a material not to dissociate, because of the affinity of its molecules for each other, is naturally important during the product distribution into the tissues of the treated area [7] .…”

Section: Discussionmentioning

confidence: 99%

Key rheological properties of hyaluronic acid fillers: from tissue integration to product degradation

Molliard¹,

Bétemps²,

Hadjab³

et al. 2018

PAR

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Aim: Over the last 15 years, hyaluronic acid (HA) fillers have become the most popular injectable biomaterial for soft tissue correction. With the increasing number of available HA fillers and the multiplication of facial treatments all over the world, there has been a need from physicians to better understand the HA fillers science. There is especially a growing interest in the science-based evaluation of rheological characteristics which represents an essential tool to guide physicians in the selection of the most appropriate HA fillers, administration techniques and depths of injection for their clinical applications. Methods: Four key rheological parameters (viscosity η, elasticity G', normal force F N and elasticity E') are measured and discussed on five HA fillers. Results: These four key rheological parameters are demonstrated to play a pivotal role, in combination with the cohesivity, for better predicting the clinical behavior of HA fillers at different stages of their lifetime. Conclusion: This article discusses the importance of four key rheological parameters during the main steps of the clinical HA fillers' lifetime, from the product injection to the loss of clinical effects. A better knowledge of these HA fillers' rheological parameters can help the physicians to optimize their aesthetic outcomes, safety and patient satisfaction.

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“… 28 Nevertheless, application of 3D-MR is restricted to the preclinical animal model, being more laborious and invasive with respect to US technique. 29 …”

Section: Discussionmentioning

confidence: 99%

A novel animal model for residence time evaluation of injectable hyaluronic acid-based fillers using high-frequency ultrasound-based approach

Merola

Scrima

Melito

et al. 2018

CCID

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BackgroundHyaluronic acid (HA)-based devices are among the most popular filler agents for skin rejuvenation. One of the principal goals is the improvement in residence time of HA-based products, to increase their performance and reduce frequency of the treatment. So, understanding fillers, behavior after subcutaneous injection is a fundamental aspect for discovery and optimization of new products. Current in vivo approaches to detect/quantify injected HA fillers are not always well optimized or easy to apply.ObjectiveTo develop more efficacious and noninvasive diagnostic tools to make a quantitative evaluation of the degradation of fillers in a small animal model.Materials and methodsWe evaluated the residence time of different HA-based fillers, fluorescein-labeled and not, injected subcutaneously in mice. Volumes of fillers were monitored through high-frequency ultrasound (HF-US) method while fluorescence intensity through the well-established fluorescence living imaging method. To confirm the effectiveness of HF-US, obtained volumetric measurements were compared with fluorescence intensity values.ResultsBoth the presented methods revealed the same degradation kinetics for the tested products.ConclusionThe two used methods are fully comparable and quantitatively accurate. The presented approach has been proved to be noninvasive, sensitive, and reproducible.

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Ultrasound and Histologic Examination after Subcutaneous Injection of Two Volumizing Hyaluronic Acid Fillers: A Preliminary Study

Abstract: Supplemental Digital Content is available in the text.

Cited by 17 publications

References 14 publications

Comparative split‐face study of durational changes in hyaluronic acid fillers for mid‐face volume augmentation

Comparative split‐face study of durational changes in hyaluronic acid fillers for mid‐face volume augmentation

Key rheological properties of hyaluronic acid fillers: from tissue integration to product degradation

A novel animal model for residence time evaluation of injectable hyaluronic acid-based fillers using high-frequency ultrasound-based approach

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