Ultrasound as a diagnostic tool in detecting active Crohn’s disease: a meta-analysis of prospective studies

Dong, Jiahao; Wang, Honggang; Zhao, Jie; Zhu, Weiming; Zhang, Liang; Gong, Jianfeng; Li, Yi; Gu, Lili; Li, Jieshou

doi:10.1007/s00330-013-2973-0

Cited by 95 publications

(86 citation statements)

References 27 publications

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“…Ultrasound, with or without oral contrast, has already had good results for assessment of the active status of CD (Dong et al 2014), and the recent application of contrast agent was found to be more precise in evaluating the microvasculature of the inflammatory intestinal wall (Di Sabatino et al 2002;Robotti et al 2004). However, the accuracy of the technique remains uncertain and is dependent on the skills of the sonographer.…”

Section: Introductionmentioning

confidence: 98%

Contrast-Enhanced Ultrasound in the Diagnosis of Patients Suspected of Having Active Crohn's Disease: Meta-analysis

Jia

et al. 2015

Ultrasound in Medicine & Biology

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Section: Introductionmentioning

confidence: 98%

Contrast-Enhanced Ultrasound in the Diagnosis of Patients Suspected of Having Active Crohn's Disease: Meta-analysis

Jia

et al. 2015

Ultrasound in Medicine & Biology

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“…Intestinal US has been reported useful for diagnosing of IBD and assessment of IBD disease activity . A recent meta‐analysis showed that US has a high diagnostic accuracy for detecting CD . The sensitivity and specificity of intestinal US in assessment of CD activity by evaluating intestinal wall inflammation were 85% and 91%, respectively .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of intestinal real‐time virtual sonography in patients with inflammatory bowel disease

Kawai

Iijima

Shinzaki

et al. 2019

J of Gastro and Hepatol

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Background and Aim Transabdominal ultrasonography (US) examination for the intestine is often difficult, and its precedence for intestinal examination depends on accessibility to experienced ultrasonographers. Real‐time virtual sonography (RVS) assists examination of US as a fusion method by synchronizing US images with pre‐captured computed tomography or magnetic resonance images. We aimed to evaluate the feasibility to use RVS for the examination of the intestine. Methods The time to scan three parts of the intestine was compared between conventional US and RVS in seven participants without intestinal diseases. Whether RVS accurately synchronized US images with reference images of intestinal target lesions was judged in 20 patients with inflammatory bowel disease. Results Examination time to scan the ascending colon and the ileocecum using intestinal RVS was significantly shorter than that using conventional US alone (36.7 vs 50.0 s [P = 0.0313] and 35.4 vs 66.4 s [P = 0.0156], respectively) in participants without intestinal diseases. Well‐synchronized US images of the intestinal lesions, such as stenosis, with reference computed tomography/magnetic resonance images were obtained by RVS in all the lesions in the fixed parts of the colon (ascending and descending colon), and images of nine lesions in 12 lesions (75%) were well synchronized in the unfixed part of the intestine in Crohn's disease patients. Conclusion Real‐time virtual sonography significantly reduced the examination time of intestinal US. Intestinal RVS can help the ultrasonographer to guide the US probe to detect and monitor intestinal lesions by synchronizing reference images, especially in inflammatory bowel disease patients (UMIN Clinical Trials Registry number: UMIN000011571).

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“…However, it is a standard part of training in many European countries including Germany and Italy, where at least 100 examinations are recommended [32]. Inexperienced sonographers have also shown to have significant ability to accurately detect disease [33].…”

Section: Discussionmentioning

confidence: 99%

Point of Care Ultrasound Accurately Distinguishes Inflammatory from Non Inflammatory Disease in Patients Presenting with Abdominal Pain and Diarrhea

Al-Farhan¹,

Al-Darmaki²,

Shim³

et al. 2017

Gastroenterology

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Background. Approaches to distinguish inflammatory bowel disease (IBD) from noninflammatory disease that are noninvasive, accurate, and readily available are desirable. Such approaches may decrease time to diagnosis and better utilize limited endoscopic resources. The aim of this study was to evaluate the diagnostic accuracy for gastroenterologist performed point of care ultrasound (POCUS) in the detection of luminal inflammation relative to gold standard ileocolonoscopy. Methods. A prospective, single-center study was conducted on convenience sample of patients presenting with symptoms of diarrhea and/or abdominal pain. Patients were offered POCUS prior to having ileocolonoscopy. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) with 95% confidence intervals (CI), as well as likelihood ratios, were calculated. Results. Fifty-eight patients were included in this study. The overall sensitivity, specificity, PPV, and NPV were 80%, 97.8%, 88.9%, and 95.7%, respectively, with positive and negative likelihood ratios (LR) of 36.8 and 0.20. Conclusion. POCUS can accurately be performed at the bedside to detect transmural inflammation of the intestine. This noninvasive approach may serve to expedite diagnosis, improve allocation of endoscopic resources, and facilitate initiation of appropriate medical therapy.

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Ultrasound as a diagnostic tool in detecting active Crohn’s disease: a meta-analysis of prospective studies

Abstract: • Ultrasound can detect active Crohn's disease (CD). • A meta-analysis of ultrasound for detecting active CD was carried out. • This revealed that ultrasound has high diagnostic accuracy for detecting CD.

Cited by 95 publications

References 27 publications

Contrast-Enhanced Ultrasound in the Diagnosis of Patients Suspected of Having Active Crohn's Disease: Meta-analysis

Contrast-Enhanced Ultrasound in the Diagnosis of Patients Suspected of Having Active Crohn's Disease: Meta-analysis

Usefulness of intestinal real‐time virtual sonography in patients with inflammatory bowel disease

Point of Care Ultrasound Accurately Distinguishes Inflammatory from Non Inflammatory Disease in Patients Presenting with Abdominal Pain and Diarrhea

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