Ultrasound assisted extraction of cynaropicrin from Cynara cardunculus leaves: Optimization using the response surface methodology and the effect of pulse mode

Brás, Teresa; Paulino, Ana F.C.; Neves, Luísa A.; Crespo, João G.; Duarte, Maria F.

doi:10.1016/j.indcrop.2020.112395

Cited by 35 publications

(22 citation statements)

References 32 publications

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“…This finding is in accordance with previous studies which also reported the superiority of the pulsed mode over continuous extraction. Lower energy input, better temperature control, and a decrease of erosion of the ultrasound probe tip are some of the advantages that have already been mentioned for PUAE [30] .…”

Section: Resultsmentioning

confidence: 99%

Continuous and pulsed ultrasound-assisted extraction of carob’s antioxidants: Processing parameters optimization and identification of polyphenolic composition

Christou

Stavrou

Kapnissi‐Christodoulou

2021

Ultrasonics Sonochemistry

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Highlights CUAE and PUAE parameters were optimized by the maximization of the yield in TPC. Compared to conventional methods, UAE offered a higher yield of antioxidants. Gallic acid was the most abundant polyphenolic compound in carob pulp extracts. Solvent concentration was the most influential processing parameter. DPA-6S demonstrated the best ability to recuperate the target analytes.

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Section: Resultsmentioning

confidence: 99%

Continuous and pulsed ultrasound-assisted extraction of carob’s antioxidants: Processing parameters optimization and identification of polyphenolic composition

Christou

Stavrou

Kapnissi‐Christodoulou

2021

Ultrasonics Sonochemistry

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“…Neither of the two reports had utilized the RSM to mathematically model the extraction process. A recent study utilized RSM to optimize the extraction of cyanopicrin [29]. The biological significance of damsin and neoambrosin necessitated the search for a green isolation technology as a preliminary step before large scale production.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-assisted extraction of damsin and neoambrosin from Ambrosia maritima: optimization using response surface methodology

et al. 2020

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Damsin and neoambrosin are two important anticancer phytopharmaceuticals of Ambrosia maritima (Damsissa). Despite their importance, no report has yet discussed their extraction from plants on lab or industrial scales. Consequently, the present article aims to develop an ultrasonic-assisted extraction (UAE) model for their extraction on the lab scale. Box-Behnken model was applied to investigate the effects of ethanol strength (X1: 40-100%), drug solvent ratio (DSR, X2: 1:20-1:60), and time (X3: 30-90 min) on the yield of damsin and neoambrosin in damsissa extract. Surprisingly, only ethanol strength was the significant factor in damsin yield with an optimum value of 55%. Time and DSR played no significant roles in damsin content. No statistically significant model could be deduced for neoambrosin. The model is a preliminary step to elucidate factors affecting the UAE of sesquiterpene lactones from plants and a preamble for its large scale green extraction.

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“…Different factors influence each other in the extraction experiment. RSM accurately assesses the correlation between these factors [ 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

Extraction, Radical Scavenging Activities, and Chemical Composition Identification of Flavonoids from Sunflower (Helianthus annuus L.) Receptacles

et al. 2021

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This study was focused on extraction, radical scavenging activities, and chemical composition identification of total flavonoids in sunflower (Helianthus annuus L.) receptacles (TFSR). We investigated the optimal extract parameters of TFSR using response surface methodology. The highest yield of TFSR was 1.04% with the ethanol concentration 58%, the material-to-liquid ratio 1:20 (v/w), the extraction time 2.6 h, and the extraction temperature 67 °C. The results of radical scavenging activities showed that ethyl acetate fraction (EAF) was the strongest by using 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2’-azino-bis (3-ethylbenzo thiazoline-6-sulfonic acid) (ABTS) and iron ion reducing analysis. The EAF had the highest flavonoids contents. Four fractions A, B, C and D were enrichment from EAF by polyamide resin. Fraction B had the highest flavonoids content. Thirteen chemical components of flavonoids in fraction B were first identified by Ultimate 3000 Nano LC System coupled to a Q Exactive HF benchtop Orbitrap mass spectrometer (UHPLC-HRMS/MS). Among of the thirteen chemical components, isoquercetin and daidzein were identified accurately by comparing with standard samples. Radical scavenging analysis showed that isoquercetin and EAF had strong activities. Therefore, sunflower receptacles can be used as a source of natural flavonoids. TFSR as a natural radical scavenger has potential applications in pharmaceutical industry.

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Ultrasound assisted extraction of cynaropicrin from Cynara cardunculus leaves: Optimization using the response surface methodology and the effect of pulse mode

Cited by 35 publications

References 32 publications

Continuous and pulsed ultrasound-assisted extraction of carob’s antioxidants: Processing parameters optimization and identification of polyphenolic composition

Continuous and pulsed ultrasound-assisted extraction of carob’s antioxidants: Processing parameters optimization and identification of polyphenolic composition

Ultrasound-assisted extraction of damsin and neoambrosin from Ambrosia maritima: optimization using response surface methodology

Extraction, Radical Scavenging Activities, and Chemical Composition Identification of Flavonoids from Sunflower (Helianthus annuus L.) Receptacles

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