Ultrasound-assisted synthesis of 2,4-thiazolidinedione and rhodanine derivatives catalyzed by task-specific ionic liquid: [TMG][Lac]

Suresh, Vignesh; Sandhu, Jagir S.

doi:10.1186/2191-2858-3-2

Cited by 30 publications

(5 citation statements)

References 38 publications

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“…Table shows important examples of advanced synthesis of drugs molecules using IL media. There are also many reports on the synthesis of molecules, which can be used as precursors for potential drugs with various activities and contain sulfonamide, lactam, imidazole, , pyrazolone, thiazole, , or thiazolidine , cores.…”

Section: Chemical Applications Of Ionic Liquids In Pharmacymentioning

confidence: 99%

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

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Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in the form of ionic liquid species. The main aim of this Review is to attract a broad audience of chemical, biological, and medical scientists to study advantages of ionic liquid pharmaceutics. Overall, the discussed data highlight the importance of the research direction defined as "Ioliomics", studies of ions in liquids in modern chemistry, biology, and medicine.

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Section: Chemical Applications Of Ionic Liquids In Pharmacymentioning

confidence: 99%

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

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“…Nitche and Klein synthesized N -substituted rhodanines from amines under microwaves using water as a solvent [ 20 ], while Azizi et al synthesized arylidene rhodanine derivatives by condensation of primary amines, aldehydes, ethyl chloroacetate, and carbon disulphide in polyethylene glycol (PEG) at room temperature or with ultrasonic irradiation [ 21 ]. Suresh and Sandhu performed the Knoevenagel condensation of rhodanines using ionic liquids under ultrasound irradiation [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Environmentally Friendly Approach to Knoevenagel Condensation of Rhodanine in Choline Chloride: Urea Deep Eutectic Solvent and QSAR Studies on Their Antioxidant Activity

et al. 2018

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A series of rhodanine derivatives was synthesized in the Knoevenagel condensation of rhodanine and different aldehydes using choline chloride:urea (1:2) deep eutectic solvent. This environmentally friendly and catalyst free approach was very effective in the condensation of rhodanine with commercially available aldehydes, as well as the ones synthesized in our laboratory. All rhodanine derivatives were subjected to 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity investigation and quantitative structure-activity relationship (QSAR) studies were performed to elucidate their structure-activity relationship. The best multiple linear QSAR model demonstrate a stability in the internal validation and Y-randomization (R2 = 0.81; F = 24.225; Q2loo = 0.72; R2Yscr = 0.148). Sphericity of the molecule, ratio of symmetric atoms enhanced atomic mass along the principle axes in regard to total number of atoms in molecule, and 3D distribution of the atoms higher electronegativity (O, N, and S) in molecules are important characteristic for antioxidant ability of rhodanine derivatives. Molecular docking studies were carried out in order to explain in silico antioxidant studies, a specific protein tyrosine kinase (2HCK). The binding interactions of the most active compound have shown strong hydrogen bonding and van der Waals interactions with the target protein.

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“…Synthesis of thiazolidine derivatives ( 82 ) was achieved via Knoevenagel condensation of various aldehydes ( 7 ) with 2,4‐thiazolidinedione ( 81 ) or rhodanine ( 81 a ) in the presence of catalytic amount of task‐specific ionic liquid 1,1,3,3‐tetramethylguanidine lactate ([TMG][Lac]) under the influence of ultrasonic irradiation at 80 °C (Scheme ) …”

Section: Ultrasound‐assisted Heterocycles Synthesis In Ionic Liquidsmentioning

confidence: 99%

Ultrasound and Ionic Liquid: An Ideal Combination for Organic Transformations

Kaur¹,

Sharma²,

Banerjee³

2018

ChemistrySelect

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Combination of ultrasound and suitable ionic liquid is a powerful tool to carry out diverse organic transformations. In many occasions, this fruitful combination helps to get the desire products without using any further catalysts even at room temperature. Recyclability of ionic liquid makes a protocol cost effective also. The present review deals with the ultrasound‐assisted organic synthesis in various ionic liquids either as catalyst or reaction media.

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Ultrasound-assisted synthesis of 2,4-thiazolidinedione and rhodanine derivatives catalyzed by task-specific ionic liquid: [TMG][Lac]

Cited by 30 publications

References 38 publications

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

Environmentally Friendly Approach to Knoevenagel Condensation of Rhodanine in Choline Chloride: Urea Deep Eutectic Solvent and QSAR Studies on Their Antioxidant Activity

Ultrasound and Ionic Liquid: An Ideal Combination for Organic Transformations

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