Ultrasound-Assisted Wound (UAW) Debridement in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis

Flores-Escobar, Sebastián; Álvaro‐Afonso, Francisco Javier; García‐Álvarez, Yolanda; López‐Moral, Mateo; Lázaro‐Martínez, José Luis; García-Morales, Esther

doi:10.3390/jcm11071911

Cited by 16 publications

(18 citation statements)

References 33 publications

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“…Larger, more homogeneous samples are obligatory for this investigation. This was also emphasised in previous studies that employed a linked meta‐analysis technique and found comparable consequences of the effect 39‐41 …”

Section: Discussionmentioning

confidence: 69%

“…This was also emphasised in previous studies that employed a linked meta-analysis technique and found comparable consequences of the effect. [39][40][41] Well-led RCTs are necessary to weigh these features as well as the blend of diverse ethnicities, gender, ages, and other parameters of subjects as the meta-analysis could not define whether differences in them are linked to the wound healing rate. In conclusion, the USSD applied to DFUs caused a significantly higher wound healing rate compared with the standard care and the placebo.…”

Section: Discussionmentioning

confidence: 99%

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Effect of ultrasound‐supported wound debridement in subjects with diabetic foot ulcers: A meta‐analysis

Chen

Xiao

Zhang

et al. 2023

International Wound Journal

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A meta‐analysis study to assess the effect of ultrasound‐supported wound debridement (USSD) in subjects with diabetic foot ulcer (DFU). A comprehensive literature examination till January 2023 was implemented and 1873 linked studies were appraised. The picked studies contained 577 subjects with DFUs in the studies' baseline, 282 of them were using USSD, 204 were using standard care, and 91 were using a placebo. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to calculate the consequence of USSD in subjects with DFUs by the dichotomous styles and a fixed or random effect model. The USSD applied to DFU caused a significantly higher wound healing rate compared with the standard care (OR, 3.08; 95% CI, 1.94–4.88, P < .001) with no heterogeneity (I2 = 0%) and the placebo (OR, 7.61; 95% CI, 3.11–18.63, P = .02) with no heterogeneity (I2 = 0%). The USSD applied to DFUs caused a significantly higher wound healing rate compared with the standard care and the placebo. Though precautions should be taken when commerce with the consequences as all of the picked studies for this meta‐analysis was with low sample sizes.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Effect of ultrasound‐supported wound debridement in subjects with diabetic foot ulcers: A meta‐analysis

Chen

Xiao

Zhang

et al. 2023

International Wound Journal

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“…This was suggested also in a previous similar meta‐analyses study which showed similar promising outcomes for low‐frequency ultrasound in improving the non‐healed chronic wound ulcers at ≥3 months and reducing the percentage of chronic wound ulcers area reduction. 34 , 45 , 46 , 47 , 48 , 49 Well‐conducted randomised controlled trials are needed to assess these factors and the combination of different gender, ages, ethnicity, and other variants of subjects; because our meta‐analysis study could not answer whether different ages and ethnicity are related to the results.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of low‐frequency ultrasound as an added treatment for chronic wounds: A meta‐analysis

Chen

Liu

et al. 2022

International Wound Journal

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We performed a meta-analysis to evaluate the effect of low-frequency ultrasound as an added treatment for chronic wounds. A systematic literature search up to May 2022 was performed and 838 subjects with chronic wounds at the baseline of the studies; 412 of them were using the low-frequency ultrasound (225 lowfrequency high-intensity contact ultrasound for diabetic foot wound ulcers, and 187 low-frequency low-intensity non-contact ultrasound for a venous leg wound ulcers), and 426 were using standard care (233 sharp debridements for diabetic foot wound ulcers and 193 sham treatments for venous leg wound ulcers). Odds ratio (OR), and mean difference (MD) with 95% confidence intervals (CIs) were calculated to assess the effect of low-frequency ultrasound as an added treatment for chronic wounds using the dichotomous, and contentious methods with a random or fixed-effect model. The low-frequency high-intensity contact ultrasound for diabetic foot wound ulcers had significantly lower non-healed diabetic foot wound ulcers at ≥3 months (OR, 0.37; 95% CI, 0.24-0.56, P < .001), a higher percentage of diabetic foot wound ulcers area reduction (MD, 17.18; 95% CI, 6.62-27.85, P = .002) compared with sharp debridement for diabetic foot wound ulcers. The low-frequency low-intensity non-contact ultrasound for a venous leg wound ulcers had a significantly lower non-healed venous leg wound ulcers at ≥3 months (OR, 0.31; 95% CI, 0.15-0.62, P = .001), and higher percentage venous Haiting Chen, Zhenxing Yu, Ning Liu, and Jianbin Huang contributed equally to the manuscript.

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“…Eight randomized controlled trials (RCTs) met their inclusion criteria in patients with diabetic foot ulcers (DFUs). 12 Ultrasound-assisted wound debridement showed higher healing rates than placebo.…”

Section: Mechanicalmentioning

confidence: 97%

“…A recent systematic review and meta-analysis by Flores-Escobar and colleagues 12 investigated ultrasound-assisted wound debridement in comparison with a placebo. Eight randomized controlled trials (RCTs) met their inclusion criteria in patients with diabetic foot ulcers (DFUs) 12 . Ultrasound-assisted wound debridement showed higher healing rates than placebo.…”

Section: Choice Of Debridement Modalitymentioning

confidence: 99%

Debridement: Technical Considerations and Treatment Options for the Interprofessional Team

Tran

Huang

Chiu

et al. 2023

Adv Skin Wound Care

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GENERAL PURPOSETo enhance the learner’s chronic wound debridement competence as an interprofessional team member.TARGET AUDIENCEThis continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.LEARNING OBJECTIVES/OUTCOMESAfter participating in this educational activity, the participant will:1. Differentiate healable, maintenance, and nonhealable wounds to create a holistic debridement treatment plan using the Wound Bed Preparation paradigm.2. Evaluate active debridement options including the potential need for an interprofessional referral or specialized investigations.3. Assess chronic wound debridement options.4. Analyze case studies for appropriate clinical application of debridement modalities.

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Ultrasound-Assisted Wound (UAW) Debridement in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis

Cited by 16 publications

References 33 publications

Effect of ultrasound‐supported wound debridement in subjects with diabetic foot ulcers: A meta‐analysis

Effect of ultrasound‐supported wound debridement in subjects with diabetic foot ulcers: A meta‐analysis

The efficacy of low‐frequency ultrasound as an added treatment for chronic wounds: A meta‐analysis

Debridement: Technical Considerations and Treatment Options for the Interprofessional Team

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