Computational fluid dynamics (CFD) shows promise in aiding clinical methods in the early detection of atherosclerosis when combined with currently popular machine learning algorithms. In this study, fluid-structure interaction (FSI) analysis of the carotid artery was performed by creating three-dimensional patient-specific pre-operation carotid artery models of four different patients which have vessel stenosis or aneurysms. As a result of numerical simulations, the average flow velocity and average pressure of the patients at 80 specific cross-sections were obtained. The simulation results of three patients’ pre-operation were used for learning in the machine learning algorithm. The training data consists of 80% of the numerical values, while the remaining 20% is used for testing. Then, the algorithm was asked to predict the flow velocity values at different cross-sections of the artery. The values obtained as a result of learning were compared with those obtained from numerical simulation. We found the results promising in terms of guiding the clinical decisions.