Ultrasound-based imaging of nanoparticles: From molecular and cellular imaging to therapy guidance

Mallidi, Srivalleesha; Wang, B.; Mehrmohammadi, Mohammad; Qu, Min; Chen, Y.-S.; Joshi, Pratixa P.; Kim, Seung-Soo; Homan, Kimberly A.; Karpiouk, Andrei; Smalling, Richard W.; Sokolov, Konstantin; Emelianov, Stanislav

doi:10.1109/ultsym.2009.5441484

Cited by 11 publications

(8 citation statements)

References 53 publications

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“…Recently another study from the same group showed the progression of photothermal treatment by quantifying the mechanical properties of tissue using a novel ultrasound based technique namely magneto-motive ultrasound [134]. Therefore, a comprehensive guidance and assessment of the PTT may be feasible through various ultrasound based imaging techniques [135]. …”

Section: Photothermal Therapy and Imaging For Cancermentioning

confidence: 99%

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Development and applications of photo-triggered theranostic agents

Rai

Mallidi

Zheng

et al. 2010

Advanced Drug Delivery Reviews

478

329

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Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal-or photo-triggered chemo-therapy for several diseases.

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Section: Photothermal Therapy and Imaging For Cancermentioning

confidence: 99%

“…During the PTT procedure approximately 25°C temperature rise was observed in the tumor. Adapted from Mallidi et al [135]. …”

Section: Figures and Tablesmentioning

confidence: 99%

Development and applications of photo-triggered theranostic agents

Rai

Mallidi

Zheng

et al. 2010

Advanced Drug Delivery Reviews

478

329

View full text Add to dashboard Cite

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“…This task now heavily rely on nanoparticles who are able to communicate with biomolecules and hence found tremendous applications as a diagnostic agent. 34 This communication between nanoparticles and tissue when decoded can find useful applications to understand the anatomical aspects of the tissue where the molecular changes have occurred. Existing noninvasive, non-ionizing diagnostic imaging techniques such as ultrasound (US) can serve as a mode to decode these communications.…”

Section: Resultsmentioning

confidence: 99%

Application of Nanoparticles in Diagnostic Imaging via Ultrasonography

Mody¹,

Siwale²

2011

Internet Journal of Medical Update - EJOURNAL

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“…5a) and the presence of nanoparticles (Fig. 5b) [81]. Photoacoustic-based thermal imaging showed significant temperature increases within the tumor which can cause tumor necrosis (Fig.…”

Section: Image-guided Therapymentioning

confidence: 99%

“…Reprinted with permission from Mallidi S, Wang B, Mehrmohammadi M, et al Ultrasound-based imaging of nanoparticles: from molecular and cellular imaging to therapy guidance. Proceedings of the 2009 IEEE Ultrasonics Symposium 2009:27–36 (2009) [81]. …”

Section: Figuresmentioning

confidence: 99%

Advances in clinical and biomedical applications of photoacoustic imaging

Wang

Wilson

et al. 2010

Expert Opinion on Medical Diagnostics

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Importance of the field Photoacoustic imaging is an imaging modality that derives image contrast from the optical absorption coefficient of the tissue being imaged. The imaging technique is able to differentiate between healthy and diseased tissue with either deeper penetration or higher resolution than other functional imaging modalities currently available. From a clinical standpoint, photoacoustic imaging has demonstrated safety and effectiveness in diagnosing diseased tissue regions using either endogenous tissue contrast or exogenous contrast agents. Furthermore, the potential of photoacoustic imaging has been demonstrated in various therapeutic interventions ranging from drug delivery and release to image-guided therapy and monitoring. Areas covered in this review This article reviews the current state of photoacoustic imaging in biomedicine from a technological perspective, highlights various biomedical and clinical applications of photoacoustic imaging, and gives insights on future directions. What the reader will gain Readers will learn about the various applications of photoacoustic imaging, as well as the various contrast agents that can be used to assist photoacoustic imaging. This review will highlight both pre-clinical and clinical uses for photoacoustic imaging, as well as discuss some of the challenges that must be addressed to move photoacoustic imaging into the clinical realm. Take home message Photoacoustic imaging offers unique advantages over existing imaging modalities. The imaging field is broad with many exciting applications for detecting and diagnosing diseased tissue or processes. Photoacoustics is also used in therapeutic applications to identify and characterize the pathology and then to monitor the treatment. Although the technology is still in its infancy, much work has been done in the pre-clinical arena, and photoacoustic imaging is fast approaching the clinical setting.

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Ultrasound-based imaging of nanoparticles: From molecular and cellular imaging to therapy guidance

Cited by 11 publications

References 53 publications

Development and applications of photo-triggered theranostic agents

Development and applications of photo-triggered theranostic agents

Application of Nanoparticles in Diagnostic Imaging via Ultrasonography

Advances in clinical and biomedical applications of photoacoustic imaging

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