Ultrasound characterization of insulin induced lipohypertrophy in type 1 diabetes mellitus

Abstract

Ultrasound scan can help identify and characterize the lipohypertrophic areas and this might be useful to improve glycemic control.

Ultrasound detection of insulin‐induced lipohypertrophy in Type 1 and Type 2 diabetes

“…Extremes of BMI have previously been suggested as risk factors for lipohypertrophy . Whereas other ultrasound studies have restricted assessment to individuals with BMI <30 kg/m 2 , the echo signature and detection in the present study were consistent across a wide range of BMIs and body habitus, which shows that these findings and techniques can be applied to the general diabetes population.…”

“…Previous characterizations of lipohypertrophy have included variable descriptions of hypo‐, iso‐ and hyperechogenic densities, which leads to more reliance on operator interpretation . Disorganization and thickening or depth of surrounding subcutaneous tissue has also been described in some participants, but inter‐individual variations in abdominal adipose tissue composition as influenced by body composition and BMI could affect these variables .…”

“…Previous characterizations of lipohypertrophy have included variable descriptions of hypo-, iso-and hyperechogenic densities, which leads to more reliance on operator interpretation [1,10,22]. Disorganization and thickening or depth of surrounding subcutaneous tissue has also been described in some participants, but inter-individual variations in abdominal adipose tissue composition as influenced by body composition and BMI could affect these variables [10,17,22]. The comprehensive echo signature described in the present study reduces variability by further defining several features that are in keeping with known underlying histological changes of lipohypertrophy.…”

Insulin-induced lipohypertrophy: clinical and ultrasound characteristics

“…По разным оценкам, распространенность индуцированных инсулином липодистрофий составляет от 5 до 53% [1][2][3][4][5]. Наличие участков липодистрофий изменяет абсорбцию препаратов инсулина из места введения [6] и способствует ухудшению качества контроля гликемии [4,5,7,8].…”

“…Однако в некоторых случаях липогипертрофии незаметны при визуальном осмотре и пальпации. Сообщалось, что точность диагностики липогипертрофий может быть повышена с помощью ультразвукового исследования (УЗИ) [7,8,10]. Вместе с тем в настоящее время стандартные протоколы ультразвуковой оценки мест введения инсулина у больных СД отсутствуют.…”