Ultrasound Diagnosis and Follow-Up of Neonate Renal Candidiasis

Abstract

Urinary tract infection by Candida Albicans is a severe condition that can occur in infants during the course of a preterm or intensive care hospitalization. Candidiasis can affect the kidney and dramatically impair renal function through involvement of the renal cortex, typically associated with potentially obstructive pelvi-caliceal fungus balls. This case report describes the case of a 4.5-month girl who developed renal candidiasis one week after her admission for upper respiratory tract infection. To manage the risk of urinary tract obstruction by fungus balls, several options were discussed and a conservative approach preferred to surgery that has a potential long-term impact on renal growth, proved effective.

Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain

“…Impaired kidney function determined by increased blood urea nitrogen level and serum creatinine was only evident in moribund mice, consistent with findings by Spellberg et al 48 , again without significant differences between hypha-forming and filamentdeficient strains. Histologically, t-EED1+ yeast were found in large numbers mainly within tubules and in the renal pelvis; it appears possible that accumulation of yeast led to obstruction of tubules and the collecting duct system 69 , increasing the intrarenal pressure and thereby, in addition to immunopathology, causes renal tissue damage. This is supported by our data showing that the area of apoptotic tissue in kidneys did not differ between mice infected with WT and t-EED1+ and suggests that the lack of hyphae-driven direct damage can be compensated by enhanced yeast cell growth.…”

Potenzial des Ultraschalls bei allogener Stammzelltransplantation und transplantationsassoziierten Komplikationen

“…Im Ultraschall lassen sich (multiple) echoarme Läsionen meist in Leber und/oder Milz darstellen, in seltenen Fällen auch in Nieren (▶ Abb. 5) [44,45].…”