Ultrasound Features of the First Metatarsophalangeal Joint in Gout and Asymptomatic Hyperuricemia: Comparison With Normouricemic Individuals

Stewart, Sarah; Dalbeth, Nicola; Vandal, Alain C.; Allen, Bruce G.; Miranda, Rhian; Rome, Keith

doi:10.1002/acr.23082

Cited by 50 publications

(34 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous controlled studies of joints in healthy, asymptomatic people have demonstrated the presence of MIFFS . They occur quite commonly.…”

Section: Miffs In Healthy Controlsmentioning

confidence: 99%

“…For instance, disk degeneration can be found in up to 37% of healthy, asymptomatic 20‐year‐old subjects and the prevalence rises to 96% of people in their 80s . Many MIFFS resemble what one would expect to see in hemophilia patients, such as synovitis, cartilage erosion and subchondral cysts . This begs the question, are the MIFFS seen in hemophilia joints due to bleeding, or are they a part of the natural aging process?…”

Section: Miffs In Healthy Controlsmentioning

confidence: 99%

See 1 more Smart Citation

Nano‐evidence for joint microbleeds in hemophilia patients

Puetz

2018

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

The concept of joint microbleeding in hemophilia patients was first proposed over 10 years ago. This was based on unexpected abnormalities found in medical imaging studies of asymptomatic joints. Since then, there have been no published studies confirming the presence of joint microbleeds. This critique will review the evidence for and against joint microbleeding in hemophilia patients and the potential implications.

show abstract

“…Numerous controlled studies of joints in healthy, asymptomatic people have demonstrated the presence of MIFFS . They occur quite commonly.…”

Section: Miffs In Healthy Controlsmentioning

confidence: 99%

Section: Miffs In Healthy Controlsmentioning

confidence: 99%

Nano‐evidence for joint microbleeds in hemophilia patients

Puetz

2018

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

show abstract

“…In addition, synovial lesion (i.e., synovial hypertrophy and synovitis) and bone erosion are also regularly detected by ultrasound in gout and hyperuricemia patients (2).…”

Section: Introductionmentioning

confidence: 99%

“…Gout is a common inflammatory disease induced by deposition of monosodium urate (MSU) crystals in joints and surrounding soft tissues. Although hyperuricemia is required for development of symptomatic gout, majority of patients with hyperuricemia do not suffer gouty arthritis, even MUS crystals are detected in joints (1,2). Chronic pain, soreness or numbness in the joints are reported in some patients without convincing clinical evidence of gouty attack.…”

Section: Introductionmentioning

confidence: 99%

Performance of Ultrasound in the Clinical Evaluation of Gout and Hyperuricemia

Cao

Zhao

Xie

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective Evaluation of monosodium urate (MSU) crystal deposition and related lesion in joints using ultrasound in gout and hyperuricemia patients. Methods Total 202 gout patients and 43 asymptomatic hyperuricemia patients were included, the clinical data and ultrasounic assessment results were collected and statistically analyzed. Results Deposition of MSU crystals were found in 25.58% (11/43) of the patients with asymptomatic hyperuricemia and 76.24% (154/202) of the patients with gout. In the all examined 1082 joints from gout patients, 33.09% (358/1082) of them were detected MSU crystals. In MSU crystal positive joints, 77.37% (277/358) of them had history of attacks. Among the joints of gouty arthritis, 56.88% (277/487) of them were found MSU crystals. Double contour sign (DCS), hyperechoic aggregate (HAG) and Tophi were found in 32.65% (159/487), 7.80% (38/487) and 24.64% (120/487) of the joints, respectively. DCS and Tophi, but not HAG, appeared inceasingly in gout duration extension. In the patients with more than 15 years of gout history, DCS, Tophi and HAG were found in 48.18%, 40.00%, 6.36% of US assessed joints, respectively. In the gout patients, synovial lesion and bone erosion were found in 17.74% (192/1082) and 7.58% (82/1082) of joints, respectively. Synovial lesion was related with HAG, while bone erosion was related to tophi and DCS. Conclusion HAG is the early sign of MSU crystal deposition in joints. Early urate lowering therapy (ULT) may reduce HAG and ameliorate synovitis and synovial hypertrophy. DCS and tophi are the risk factors of bone erosion. Early ULT should be considered in the gout patients with DCS or tophi.

show abstract

“…But there is a lack of studies investigating the relationship between the clinical symptoms and spread of US findings in gout. The studies with asymptomatic hyperuricemia [12,13] or gout studies investigating both: the symptomatic and the contralateral joint [14] showed that T, double contour (DC), and even erosions (E) can be found in the joint, in which symptoms have never been reported, raising the question of concordance between the clinics and US changes. Which joints should be investigated for gout classification, just the symptomatic joints or more, independently of symptoms, this is still a matter of discussion.…”

Section: Introductionmentioning

confidence: 99%

Pacientų, Kuriems Nustatytas Sukėlėjas, Atlikus 7 Lytiškai Plintančių Infekcijų Molekulinį Tyrimą, Rezultatų Analizė

et al. 2017

View full text Add to dashboard Cite

SummaryFor the first time, the new ACR/EULAR gout classification criteria incorporate ultrasound (US) evidence of double contour sign (DC), an articular cartilage abnormality related to the deposition of crystals on the surface of the hyaline cartilage, as a sign specific to gout. US recently has been used as an objective diagnostic tool for detecting urate deposition (tophus (T), DC) or joint damage (erosion) in gout. Objective: Our aim was to investigate the relationship between clinical gout activity and load of US changes, also to examine the concordance between patient reported joint attack (PRGA) and ultrasonographic intraarticular changes. Methods: Sixty monosodium-urate-crystal-confirmed gout patients and 36 healthy controls were prospectively included in one centre. The relationship between clinical symptoms and ultrasonographic gout-related changes investigating 36 joints and 4 tendons (m. triceps and patellar) was evaluated using Spearman's correlation and agreement analysis (kappa coefficient). Results: moderate, positive correlation was observed between the number of subcutaneous tophi and total US tophus area (rs=0,628), total number of DC (rs=0,612), and erosions (rs=0,526), all p<0, 0001, found per patient on US. Gout attacks and disease duration significantly positively correlated with the load of all investigated US changes (p<0, 01).

show abstract

Ultrasound Features of the First Metatarsophalangeal Joint in Gout and Asymptomatic Hyperuricemia: Comparison With Normouricemic Individuals

Cited by 50 publications

References 46 publications

Nano‐evidence for joint microbleeds in hemophilia patients

Nano‐evidence for joint microbleeds in hemophilia patients

Performance of Ultrasound in the Clinical Evaluation of Gout and Hyperuricemia

Pacientų, Kuriems Nustatytas Sukėlėjas, Atlikus 7 Lytiškai Plintančių Infekcijų Molekulinį Tyrimą, Rezultatų Analizė

Contact Info

Product

Resources

About