Ultrasound-Guided Fine-Needle Aspiration Biopsy of Thyroid Nodules: Comparison in Efficacy According to Nodule Size

Kim, Dong Wook; Lee, Eun Joo; Kim, Sang Hyo; Kim, Tae Hyun; Lee, Sang Hyub; Kim, Dae Hwan; Rho, Myung Ho

doi:10.1089/thy.2008.0106

Cited by 104 publications

(82 citation statements)

References 16 publications

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“…Low-echoic halo, a hypoechoic rim surrounding the outer margin of a nodule, can represent a tumor capsule, a fibrotic pseudocapsule, compressed normal thyroid tissue, or chronic inflammatory infiltrates. 16,18 These features may be common to benign lesions, [19][20][21] a finding supported by our results. Our study had several limitations, including its retrospective design and the small number of patients, which may have introduced a selection bias.…”

supporting

confidence: 90%

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Jeong²,

Shong³

et al. 2011

AJNR Am J Neuroradiol

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supporting

confidence: 90%

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Jeong²,

Shong³

et al. 2011

AJNR Am J Neuroradiol

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“…In our study, no correlation between nodular size and cytology results was found. In our opinion, as already reported in the literature (Sidoti et al, 2006;Gharib and Papini, 2007;Kim et al, 2009), only specific reasons, such as US features of cancer, history of thyroid irradiation, a family history of thyroid cancer, or local symptoms, justify FNAB in thyroid nodules of less than 1 cm.…”

Section: Discussionsupporting

confidence: 63%

“…False-negative rates, between 0.2% and 5.0% (Gharib and Papini, 2007;Nayar and Ivanovic, 2009), are deemed acceptable. Nodular size is crucial to a reliable cytology result, and some authors (Kim et al, 2009), but not all (Nam-Goong et al, 2004), discourage the routine use of US-FNAB to diagnose thyroid nodules of less than 1 cm. In our study, no correlation between nodular size and cytology results was found.…”

Section: Discussionmentioning

confidence: 99%

Is there a real diagnostic impact of elastosonography and contrast-enhanced ultrasonography in the management of thyroid nodules?

Giusti¹,

Orlandi²,

Melle³

et al. 2013

J. Zhejiang Univ. Sci. B

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Abstract:Ultrasonography (US) and the new applications US elastography (USE) and contrast-enhanced US (CEUS) are used in the screening of thyroid nodules, for which fine-needle aspiration biopsy (FNAB) is the best single diagnostic test. The aim of the study was to compare the sensitivity, specificity, positive predictive value (PPV), and accuracy of the four examinations in nodules with cytological and histological diagnoses. The study used data from US, FNAB, USE (elasticity (ELX 2/1) index), and CEUS (Peak index and time to peak (TTP) index) evaluated in 73 thyroid nodules in 63 consecutive patients likely to undergo surgery. Cytological-histological correlation was available for 38 nodules. No correlation emerged between nodule size and cytological results. A significant (P=0.03) positive correlation between cumulative US findings and cytological results was found. In addition, significant correlations between cumulative US findings and cytology (P=0.02) and between cumulative US findings and histology (P<0.0001) were found. US showed the best specificity and PPV, and FNAB the best sensitivity. There was no significant difference in the ELX 2/1 index, Peak index, or TTP index among nodules subdivided according to cytological scores. No significant correlation was found between ELX 2/1 index, Peak index, and TTP index, on the one hand, and nodule size, US cumulative findings, cytology, and histology on the other hand. The sensitivity of the ELX 2/1 index was high, but its specificity was very low. The accuracy and PPV of USE were lower than those of the other procedures. Only the correlation between Peak index and cumulative US findings reached a value close to significance. Our ultimate aim is to minimise unnecessary thyroidectomy. US and FNAB continue to play a central diagnostic role. The use of a US score showed high specificity and PPV. The specificity of FNAB was low in this selected series because of the numbers of indeterminate cytological responses. USE and CEUS are innovative techniques that need to be standardized. The ELX 2/1 index, Peak index, and TTP index seem to be unrelated to histology. The best statistical data on USE and CEUS concerned their sensitivity and PPV, respectively. At present, USE and CEUS are too time-consuming and of limited utility in selecting patients for surgery.

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“…However, this rate of malignancy for the PCTNs was significantly lower than the frequency of malignancy for thyroid nodules (25.6%, 112/438) on the basis of thyroid sonography and consecutive US-FNAB in our hospital. 12 Therefore, the findings showed that the frequency of malignant PCTNs is relatively low compared with the frequency of malignancy in solid thyroid nodules.…”

Section: Discussionmentioning

confidence: 92%

Sonographic Differentiation of Partially Cystic Thyroid Nodules: A Prospective Study

Kim

Lee²,

In³

et al. 2010

AJNR Am J Neuroradiol

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Ultrasound-Guided Fine-Needle Aspiration Biopsy of Thyroid Nodules: Comparison in Efficacy According to Nodule Size

Cited by 104 publications

References 16 publications

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Collapsing Benign Cystic Nodules of the Thyroid Gland: Sonographic Differentiation from Papillary Thyroid Carcinoma

Is there a real diagnostic impact of elastosonography and contrast-enhanced ultrasonography in the management of thyroid nodules?

Sonographic Differentiation of Partially Cystic Thyroid Nodules: A Prospective Study

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