Ultrasound-guided percutaneous ethanol injection in the treatment of autonomous thyroid nodules — a review

Pm, Schumm-Draeger

doi:10.1055/s-0029-1212059

Cited by 15 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In concordance with the literature [6,15,16], efficacy was not different among patients with these types of nodules, when compared to the efficacy that was observed in patients with solid nodules.…”

Section: Cytological Findingssupporting

confidence: 90%

Changes Associated with Percutaneous Ethanol Injection in the Treatment of Thyroid Nodules

et al. 2011

View full text Add to dashboard Cite

Percutaneous ethanol injection (PEI) is an alternative therapy for thyroid nodules (TN). However, some concern is raised on its carcinogenic effects. To evaluate the cytological and clinical changes caused by PEI in patients with benign TN. Thirty-nine patients with TN (23.1% hyperfunctioning) were submitted to a median of three PEI sessions. After a median of 17 months, patients were reassessed. A new ultrasound-guided fine needle biopsy (US-FNB) was performed, and the smears were analyzed after May-Grünwald-Giemsa staining. The diagnostic findings and the cellular characteristics were compared before and after treatment. There was an increase in the proportion of nondiagnostic/unsatisfactory results (from 2.5% to 18.9%). No malignant cases were observed. The proportion of moderate/intense macrophage infiltration decreased from 60% to 15%. Before treatment, 23.1% patients had hyperthyroidism, which was completely or partially resolved in 66.7%. By ultrasound, the percentage of homogeneous nodules decreased from 64.0% to 38.4% (p=0.0235), and the mean nodule volume decreased from 13.4 ± 12.2 to 5.3 ± 5.1 cm(3). We demonstrate that PEI increases the proportion of nondiagnostic/unsatisfactory results from US-FNB. Therefore, cytological findings after PEI must be evaluated with caution. Our results also suggest that PEI is an efficacious and safe therapeutic option, with no carcinogenic effects observed on cytological evaluations. Safety and efficacy must be evaluated in larger studies with longer follow-up periods.

show abstract

Section: Cytological Findingssupporting

confidence: 90%

Changes Associated with Percutaneous Ethanol Injection in the Treatment of Thyroid Nodules

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Transurethral ethanol ablation of the prostate is among these minimally invasive techniques, due to its necrotizing effect on prostatic tissue. Dehydrated ethanol use for prostate ablation results from previous clinical evidence of its use in the treatment of various lesions, such as thyroid adenoma [2] and hepatocellular carcinoma [3], or for the ablation of renal cysts [4]. Ethanol, when injected into tissues, induces hemorrhagic coagulation necrosis associated to arterioles and venules thrombotic occlusion [5].…”

Section: Introductionmentioning

confidence: 99%