Ultrasound measurement of fetal size in rural Guatemala

Neufeld, L.M.; Haas, Jere D.; Grajeda, Rubén; Martorell, Reynaldo

doi:10.1016/s0020-7292(03)00335-7

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…The growth plate remained stable, resulting in continuous, linear bone growth throughout the whole simulation period (48 weeks, 16 weeks after birth). The total bone growth rate as well as the number of cells predicted by the model corresponded to literature values (Chitty and Altman, 2002;Honarvar et al, 2001;Neufeld et al, 2004). Hence, we conclude that the growth factors PTHrP, Ihh and VEGF together could regulate linear growth in a long bone.…”

Section: Discussionsupporting

confidence: 81%

Can the growth factors PTHrP, Ihh and VEGF, together regulate the development of a long bone?

Brouwers

Donkelaar

Sengers

et al. 2006

Journal of Biomechanics

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Section: Discussionsupporting

confidence: 81%

Can the growth factors PTHrP, Ihh and VEGF, together regulate the development of a long bone?

Brouwers

Donkelaar

Sengers

et al. 2006

Journal of Biomechanics

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“…The results of the ultrasound examination were also recorded on a report form, which was given to the participant for her information and medical follow-up. A description of fetal size for gestational age compared with reference values is presented elsewhere (22).…”

Section: Ultrasound Measurementsmentioning

confidence: 99%

Changes in maternal weight from the first to second trimester of pregnancy are associated with fetal growth and infant length at birth

Neufeld

Haas

Grajeda

et al. 2004

The American Journal of Clinical Nutrition

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Background: Despite our knowledge of the negative consequences of stunting during early childhood and the important role that maternal nutritional status plays in the development of intrauterine growth retardation, we do not know the extent to which maternal nutritional status influences the growth in length of the fetus or whether a sensitive period for fetal linear growth exists during gestation. Objective: Our objective was to explore the relation between maternal weight gain during different stages of pregnancy and linear growth of the fetus. Design: Ultrasound examinations were conducted at 15-24 (x : 17.5) and 28 -32 (x : 29.9) wk of gestation in 200 women from 4 rural Guatemalan villages. The associations between maternal weight gain from Ȃ10 to 20 and 20 to 30 wk of pregnancy (from the first to the second and from the second to the third trimester, respectively) and fetal linear growth were tested with the use of ordinary leastsquares regression. Results: Maternal weight gain from the first to the second trimester was associated with fetal femur and tibia lengths measured at both means of 17 and 30 wk (P 0.05) and infant length at birth (P 0.001). Weight gain from the second to the third trimester of pregnancy did not predict fetal linear growth or infant length at birth. Conclusions: Maternal weight change from the first to the second trimester of pregnancy is strongly associated with fetal growth. Midgestation may be a sensitive period for fetal linear growth.Am J Clin Nutr 2004;79:646 -52.

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“…If this is the case, there should be some similarities between growth patterns in nutritionally challenged samples and those facing hypoxic exposure. Some perspective on this can be gained from a study of fetal growth among a sample of marginally malnourished (defined by short maternal height and low total weight gain during pregnancy) rural Guatemalans (Neufeld et al, 2004). Compared to a well-nourished fetal reference sample, the fetal growth pattern among the rural Guatemalans was neither proportional nor head-sparing.…”

Section: Hypoxia/energy System: Does This Work At the Level Of The Pomentioning

confidence: 99%

Cellular life histories and bow tie biology

Lampl

2004

Am. J. Hum. Biol.

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Considering the life-long influences of fetal growth biology, it is of interest to further elucidate the nature of the fetal growth process itself. Previous analyses of longitudinal fetal ultrasound data led to the hypothesis that hypoxia signals were important aspects of normal growth biology and directed attention to the place of oxygen as a basic nutrient. From the perspective of the cell, both hypoxia and lack of energy substrate trigger a common adaptive pathway through their effects on ATP availability. Comparative data from animal studies and cell culture provide evidence for an integrated energy/oxygen signaling system that acts redundantly and hierarchically with cellular differentiation programs, providing opportunities for developmental flexibility in response to variable ecologic or environmental challenge. The multinodal and interactive design of the fetal growth process suggests that it follows what has been described as the "bow tie" model of metabolism, with implications for robust and inventive approaches to cell, organ, and whole organism construction.

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Ultrasound measurement of fetal size in rural Guatemala

Abstract: Fetal growth faltering begins in early gestation among infants who were born small. The lack of deviation from reference data for FL and AC requires further clarification.

Cited by 13 publications

References 15 publications

Can the growth factors PTHrP, Ihh and VEGF, together regulate the development of a long bone?

Can the growth factors PTHrP, Ihh and VEGF, together regulate the development of a long bone?

Changes in maternal weight from the first to second trimester of pregnancy are associated with fetal growth and infant length at birth

Cellular life histories and bow tie biology

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