Ultrasound‐Mediated Monodesulfonation of Polyphenol Sulfonate and One‐Pot Generation of Alkyl Aryl Ether under Solvent‐Free Conditions

Abstract

An effective approach for monodesulfonation of polyphenol sulfonate under ultrasonic irradiation was reported. Series of substituted ortho‐, meta‐ or para‐hydroxylphenol sulfonates or 5‐hydroxy‐1,3‐phenylene bis(4‐methylbenzenesulfonate) were obtained specifically in the presence of sodium hydroxide in acetonitrile. With treatment of potassium carbonate in alcohol, alkyloxylphenol sulfonates was provided via one‐pot monodesulfanation followed by alkylation under ultrasonicated solvent‐free conditions. The alcohol had been regarded as green alkylation reagent. The results of the exploration of the scalability of monodesulfonation and one‐pot monodesulfonation‐alkylation of resorcinol bissulfonate indicated that such modes had the potential application value in scale production.

CuFe2O4 Magnetic Nanoparticles as Heterogeneous Catalysts for Synthesis of Dihydropyrimidinones as Inhibitors of SARS-CoV-2 Surface Proteins—Insights from Molecular Docking Studies

“…Nanoparticles with large surface areas show remarkable catalytic activity in organic reactions, and the utilization of heterogeneous catalysts for the Biginelli reaction has already been explored [14][15][16]. In recent decades, ultrasound-mediated processes gained significant traction, with reports of several successful chemical procedures employing this technique [17][18][19][20]. Ultrasound-assisted reactions offer numerous advantages over conventional heating methods, including faster reaction times, the reduced formation of undesirable by-products, the production of clean products with high yields, the simplicity of operation in open systems, and milder reaction conditions.…”