Ultrasound-promoted one-pot five-components synthesis of biologically active novel bis((6-alkyl or phenyl-2-phenylpyrimidine-4-yl) oxy) alkane or methyl benzene derivatives

Abstract

We have described a synthesis of novel five-component reaction (5-CR) of bis((6-alkyl or phenyl-2-phenylpyrimidine-4-yl) oxy) alkane or methyl benzene derivatives under ultrasound irradiation. A useful ultrasound effect was observed and title products were obtained with high yields after 25-40 min sonication. Structural confirmation and characterization of the products based on the analytical, chemical, and spectral analysis. The results show obviously, that to reach a high efficiency of ultrasonic systems in synthetic chemical processes. Our procedure compared to the conventional heating method has the benefit of higher reaction yields and shorter reaction times. The in vitro antibacterial tests show that some of the target compounds have promising activities. Structure-activity relationships (SAR) were established for the substitutions on the pyrimidine rings and related length of linear chain linker.

Green and Highly Efficient Synthesis of Mono- and Bis-Benzothiazoles in the Presence of Fe(SD)3under Ultrasound Irradiation

“…Therefore, in an effort to design a new method for the synthesis of benzothiazoles and also encouraged by our reasonable success in using ultrasound irradiation in organic synthesis and synthesis of bis‐compounds, we investigate the synthesis of mono‐ and bis‐benzothiazoles 3a and 3n from 2‐aminothiophenol 1 and different aldehydes 2a and 2n in water as solvent under ultrasound irradiation (Scheme ). Synthesis of 3a was studied as a model reaction.…”

Synthesis of Thiazole Derivatives as Antimicrobial Agents by Green Chemistry Techniques

“…Even so, sonication has been applied successfully in many of organic reactions providing enhancement of reactions rates and yield as well as modification of the reaction pathway, greater selectivity, simplicity of operation, and energy-saving protocols. (25). Moreover, this way has led to develop a simple purification process suitable with the concept of green chemistry (26,27).…”