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We have described a synthesis of novel five-component reaction (5-CR) of bis((6-alkyl or phenyl-2-phenylpyrimidine-4-yl) oxy) alkane or methyl benzene derivatives under ultrasound irradiation. A useful ultrasound effect was observed and title products were obtained with high yields after 25-40 min sonication. Structural confirmation and characterization of the products based on the analytical, chemical, and spectral analysis. The results show obviously, that to reach a high efficiency of ultrasonic systems in synthetic chemical processes. Our procedure compared to the conventional heating method has the benefit of higher reaction yields and shorter reaction times. The in vitro antibacterial tests show that some of the target compounds have promising activities. Structure-activity relationships (SAR) were established for the substitutions on the pyrimidine rings and related length of linear chain linker.

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Novel 2,8‐dithioxopyrano[2,3‐d:6,5‐d′]dipyrimidine‐4,6(1H)‐dione derivatives were synthesized by a clean and efficient methodologies involving one‐pot regioselective and chemoselective reactions between two moles substituted thiobarbituric acid and 1 mol various aromatic aldehydes in the presence of p‐toluenesulfonic acid as a catalyst in EtOH with good yields in compression with alternative conditions such as microwave and promoted ultrasound. All of the compounds have been characterized by IR, 1H NMR, 13C NMR spectral data, and elemental analyses.

Title compounds (III) are prepared by TosOH‐catalyzed reaction of aromatic aldehydes with (substituted) thiobarbituric acid.