Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules

Pei, Shufang; Zhang, Bin; Cong, Shan; Liu, Juanjuan; Wu, Suqing; Dong, Yang; Zhang, Lu; Zhang, Shuixing

doi:10.1155/2020/1749351

Cited by 25 publications

(18 citation statements)

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“…This meta-analysis uncovered that RTE had greater diagnostic value than SWE in distinguishing malignant from benign nodules ( 32 ). Furthermore, the ES of RTE was intensely associated with the malignant risk stratification of TI-RADS ( 33 ). Some researches applied SWE to forecast CLNM in PTC patients, the results demonstrated that SWE can improve the performance for preoperative lymph node staging ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Web-Based Ultrasonic Nomogram Predicts Preoperative Central Lymph Node Metastasis of cN0 Papillary Thyroid Microcarcinoma

et al. 2021

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BackgroundMany clinicians are facing the dilemma about whether they should apply the active surveillance (AS) strategy for managing Clinically Node-negative (cN0) PTMC patients in daily clinical practice. This research plans to construct a dynamic nomogram based on network, connected with ultrasound characteristics and clinical data, to predict the risk of central lymph node metastasis (CLNM) in cN0 PTMC patients before surgery.MethodsA retrospective analysis of 659 patients with cN0 PTMC who had underwent thyroid surgery and central compartment neck dissection. Patients were randomly (2:1) divided into the development cohort (439 patients) and validation cohort (220 patients). The group least absolute shrinkage and selection operator (Group Lasso) regression method was used to select the ultrasonic features for CLNM prediction in the development cohort. These features and clinical data were screened by the multivariable regression analysis, and the CLNM prediction model and web-based calculator were established. Receiver operating characteristic, calibration curve, Clinical impact curve and decision curve analysis (DCA) were used to weigh the performance of the prediction model in the validation set.ResultsMultivariable regression analysis showed that age, tumor size, multifocality, the number of contact surface, and real-time elastography were risk factors that could predict CLNM. The area under the curve of the prediction model in the development and validation sets were 0.78 and 0.77, respectively, with good discrimination and calibration. A web-based dynamic calculator was built. DCA proved that the prediction model had excellent net benefits and clinical practicability.ConclusionsThe web-based dynamic nomogram incorporating US and clinical features was able to forecast the risk of preoperative CLNM in cN0 PTMC patients, and has good predictive performance. As a new observational indicator, NCS can provide additional predictive information.

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Section: Discussionmentioning

confidence: 99%

Web-Based Ultrasonic Nomogram Predicts Preoperative Central Lymph Node Metastasis of cN0 Papillary Thyroid Microcarcinoma

et al. 2021

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“… 12 Furthermore, the addition of RTE had been shown to improve the diagnostic accuracy of TI-RADS. 22 In suspected prostate cancer, RTE has been found to be useful in combination with Prostate Cancer Gene 3 (PCG3) scores as a pre-biopsy diagnostic indicator to reduce the number of prostate biopsies. 23 In addition, RTE in combination with magnetic resonance imaging (MRI) has been found to increase precision of localizing prostate cancer lesions compared with MRI alone.…”

Section: Discussionmentioning

confidence: 99%

Combining real-time elastography with fine-needle aspiration biopsy to identify malignant thyroid nodules

Zhu

Chen

et al. 2020

J Int Med Res

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Objectives To evaluate the diagnostic performance of real-time elastography (RTE) combined with fine-needle aspiration (FNA) biopsy in identifying malignant thyroid nodules. Methods This was a single-centre, retrospective study and involved patients who had underogone partial or total thyroidectomy from 01 January 2014 to 31 December 2018 at our centre. Eligible patients were at least18 years of age, had reliable grayscale ultrasound imaging results, a RTE evaluation and had undergone a FNA biopsy. Results Data were available from 437 patients. A high RTE score was a significant independent risk factors for malignancy. RTE plus FNA biopsy increased diagnostic accuracy compared with either method alone and the sensitivity and specificity of the combined model were 86% and 78%, respectively. Conclusions The combination of RTE imaging with FNA biopsy improves the diagnostic performance in differentiating benign and malignant thyroid nodules.

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“…Однако трансректальное ультразвуковое исследование не является высокочувствительным или специфичным для диагностики РПЖ [7]. Между тем цветная и энергетическая допплеровская визуализация существенно не улучшают диагностическую точность [8]. Лишь патологический результат, полученный при трансректальной УЗИ-биопсии, остается основой подтверждения PПЖ [3].…”

Section: наилучшее значение порогового значенияunclassified

“…Прогрессия и летальность при Глисон 6 были намного ниже, чем Глисон ≥7 [35,36]. В некоторых исследованиях [3,8,11,17] сообщалось, что частота выявления рака предстательной железы с более высокой оценкой по шкале Глисона была выше, чем при низких значений по шкале Глисона. В настоящем исследовании не было никаких существенных различий между средними показателями для Глисона <7 и таковыми для Глисона ≥7.…”

Section: наилучшее значение порогового значенияunclassified

“…С помощью трансректальной эластографии в реальном времени (TРЭ) можно оценить различия в деформации ткани, возникающей при сжатии. TРЭ призван прежде всего дифференцировать доброкачественные и злокачественные ткани [7,8]. Как новый метод биомеханики TРЭ восполняет недостаток обычного режима ультразвуковой визуализации с лучшей диагностической ценностью для РПЖ.…”

Section: Introductionunclassified

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Значение Эластографии В реальном Времени В диагностике Рака Простаты

Азаб¹,

Родович²

2021

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Цель: оценить клиническую значимость трансректальной эластографии в реальном времени (TРЭ) в диагностике рака предстательной железы (PПЖ).Методы: в исследование были включены 195 пациентов с повышенным уровнем ПСА. Анализ кривой ошибок (ROC) проводился для оценки диагностической эффективности TРЭ.Результаты: баллы TРЭ у пациентов с PПЖ и доброкачественным состоянием составляли 3,20 ± 1,11 (диапазон: 1–5) и 2,24 ± 1,01 (диапазон: 1–4), соответственно (P <0,001). Наилучшее пороговое значение показателя TРЭ составило 3, а чувствительность, специфичность, точность в диагностике РПЖ составили 68,6% (35/51), 69,4% (100/144) и 69,2% (135/195), соответственно. Точность TРЭ при объеме ПЖ ≤30 мл была значительно выше, чем в группе объема ≥50 мл и в группе 30–50 мл (76,9% против 65,0% и 76,9% против 71,4%, в обеих группах P <0,001). Точность оценки TРЭ была выше для пациентов с ПСА в диапазоне 4–10 нг/мл, чем для пациентов с ПСА > 10 нг/мл (85,3% против 66,7%, P = 0,002).Вывод: полуколичественная оценка жесткости предстательной железы может служить полезным методом скрининга для пациентов с подозрением PПЖ, особенно для тех, у которых повышенный уровень ПСА не сопровождается клиническими проявлениями.

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Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules

Cited by 25 publications

References 43 publications

Web-Based Ultrasonic Nomogram Predicts Preoperative Central Lymph Node Metastasis of cN0 Papillary Thyroid Microcarcinoma

Web-Based Ultrasonic Nomogram Predicts Preoperative Central Lymph Node Metastasis of cN0 Papillary Thyroid Microcarcinoma

Combining real-time elastography with fine-needle aspiration biopsy to identify malignant thyroid nodules

Значение Эластографии В реальном Времени В диагностике Рака Простаты

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