Ultrasound Stimulation Potentiates Management of Diabetic Hyperglycemia

Chang, Chia-Hsuan; Fan, Kang-Chih; Cheng, Yuan-Pin; Chen, Jung-Chih; Chen, Gin-Shin

doi:10.1016/j.ultrasmedbio.2023.01.012

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…Many studies have proved that electroacupuncture at ST36 was able to promote the gastric emptying in DGP 26–28 . As a non‐invasive therapy, reports have confirmed ultrasound stimulation with acupoint may have potential in the management of diabetic hyperglycemia 7 . Our previous study revealed the positive impact of LIPUS combined with ST36 on diabetes‐induced impairment in gastric motility 29 .…”

Section: Discussionmentioning

confidence: 80%

“…[26][27][28] As a non-invasive therapy, reports have confirmed ultrasound stimulation with acupoint may have potential in the management of diabetic hyperglycemia. 7 Our previous study revealed the positive impact of LIPUS combined with ST36 on diabetes-induced impairment in gastric motility. 29 Similarly, in this study, we reaffirmed that LIPUS accelerated the gastric emptying rate and improved the contractility of GSMCs.…”

Section: Discussionmentioning

confidence: 95%

“…Low‐intensity pulsed ultrasound (LIPUS), as a promising treatment, can effectively produce positive effects by stimulating neuronal activity 4–6 . In recent years, significant interests have been generated in the role of LIPUS combined with acupoint in neuromodulation due to its ability to penetrate deep into tissue noninvasively 7 . Nevertheless, the effects and specific mechanisms of LIPUS combined with ST36 stimulation on DGP remain incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

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Low‐intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR‐449a/DLL1 signaling in diabetic rats

Han,

Cheng,

Jin

et al. 2024

Neurogastroenterology Motil

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BackgroundLow‐intensity pulsed ultrasound (LIPUS) combined with acupoint can promote gastric motility of diabetic rats. The switch of gastric smooth muscle cell (GSMCs) phenotype was related to the diabetes‐induced gastric dysfunction, but the mechanism is not clearly elucidated. This study was aimed at exploring the underlying mechanism of LIPUS stimulation application in diabetic gastroparesis rats.MethodsIn this study, Sprague–Dawley male rats were divided into three groups: control group (CON), diabetic gastroparesis group (DGP), and LIPUS‐treated group (LIPUS). LIPUS irradiation was performed bilaterally at ST36 for 20 min per day for 4 weeks. The gastric emptying rate was measured by ultrasound examination. Contraction ability of GSMCs was assessed by muscle strip experiment. The expression of related proteins or mRNAs including α‐SMA, SM22α, MHC, RhoA, Rock2, p‐MYPT1, MYPT1, p‐MLC, MLC, MALAT1, miR‐449a, and DLL1 was detected by different methods such as western blotting, RT‐qPCR, immunohistochemistry, and immunofluorescence staining, as appropriate.Key Results(a) LIPUS stimulation at ST36 could improve the gastric motility dysfunction of diabetic rats. (b) LIPUS increased RhoA, Rock2, p‐MYPT1, and p‐MLC expression level. (c) MALAT1 and DLL1 contents were decreased, but the level of miR‐449a was increased in the LIPUS group.Conclusions & InferencesLIPUS may affect the contractile marker expression of gastric smooth muscle through the RhoA/Rock and MALAT1/miR‐449a/DLL1 pathway to ameliorate DGP.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Low‐intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR‐449a/DLL1 signaling in diabetic rats

Han,

Cheng,

Jin

et al. 2024

Neurogastroenterology Motil

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Endogenous opiates and behavior: 2023

Bodnar

2024

Peptides

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Ultrasound Pancreatic Stimulation: A Novel Strategy for Insulin Release and Diabetes Management

Khalafpour

2024

J Bio-X Res

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Diabetes mellitus remains a global health care challenge, promoting the search for innovative treatments. In vivo and in vitro studies have shown the potential benefits of ultrasound (US) on enhancing insulin release and reactivating pancreatic β cell function. As a novel, nonpharmacological, noninvasive, and cost-effective approach, US therapy holds promise for stimulating pancreatic function and improving insulin secretion. This review explores recent findings on US therapy, focusing on low-intensity US (LIUS) and its effects on varying treatment parameters. Despite promising results, conflicting evidence highlights the need for further investigation through large-scale clinical trials to establish the therapeutic potential of US therapy and to optimize treatment regimens for effective diabetes management. The biological response to LIUS is complex and involves multiple cell types and pathways. The mechanisms triggering these effects require further exploration. A future engineering challenge lies in designing an experimental setup to control the US-induced mechanical phenomena, enabling the evaluation of biological effects with respect to parameters such as intensity, frequency, or duty cycle.

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Ultrasound Stimulation Potentiates Management of Diabetic Hyperglycemia

Cited by 3 publications

References 44 publications

Low‐intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR‐449a/DLL1 signaling in diabetic rats

Low‐intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR‐449a/DLL1 signaling in diabetic rats

Endogenous opiates and behavior: 2023

Ultrasound Pancreatic Stimulation: A Novel Strategy for Insulin Release and Diabetes Management

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