Ultrasound strain imaging in assessment of false vocal folds in adults: A feasibility study

Gao, Jing; Xia, Chunxia; Zhu, Qi; Hamilton, James; Min, Robert J.

doi:10.1016/j.clinimag.2018.05.013

Cited by 8 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Randomized control trials and nonrandomized retrospective or prospective observational studies that met the following criteria were included in this meta‐analysis. Inclusion criteria were studies involving: late adolescent and/or adult patients (age ≥ 16 years) as this was observed to be a common age limit used in studies examining adult populations, laryngeal US assessment was compared to a reference method evaluating TVFI, studies were published with a description of the results in the English language. Studies were excluded if they: had insufficient data to calculate 2 × 2 tables despite direct communication with the authors of the original manuscripts; were studies of animals or cadaveric tissue, case reports, case series of fewer than 10 cases, review articles, abstracts, editorials, and previously published meta‐analyses on related subjects; used strain US to qualify vocal cord movement due to differences in methodology and thresholds for diagnosis 11 Due to variability in classifying degrees of paresis versus paralysis, results for both categories were aggregated when studies provided data for both.…”

Section: Methodsmentioning

confidence: 99%

“…had insufficient data to calculate 2 Â 2 tables despite direct communication with the authors of the original manuscripts; 2. were studies of animals or cadaveric tissue, case reports, case series of fewer than 10 cases, review articles, abstracts, editorials, and previously published meta-analyses on related subjects; 3. used strain US to qualify vocal cord movement due to differences in methodology and thresholds for diagnosis. 11 Due to variability in classifying degrees of paresis versus paralysis, results for both categories were aggregated when studies provided data for both. Because of the potential confounding from effects of anesthesia in the postoperative period, which could affect cord mobility and reliable diagnosis of TVFI, a sensitivity analysis was performed excluding observations performed while patients were anesthetized.…”

Section: Study Selection and Data Extractionmentioning

confidence: 99%

See 1 more Smart Citation

Laryngeal Ultrasound Detects Vocal Fold Immobility in Adults

Hamilton

Tawfik

et al. 2021

J of Ultrasound Medicine

View full text Add to dashboard Cite

Laryngeal ultrasound (US) is becoming widely accepted for assessing true vocal fold immobility (TVFI), a potential complication of laryngeal and thyroid surgery. The objective of this project is to perform a systematic review and meta‐analysis of pooled evidence surrounding laryngeal US as a modality for diagnosing TVFI in adults at risk for the condition in comparison to laryngoscopy as a gold standard. Medical subject heading terms were used to search MEDLINE, Embase, Google Scholar, Web of Science, and the Cochrane Library for relevant citations from January 1, 2000, to June 30, 2020. Studies were included if they involved patients 16 years and older, where laryngeal US was compared to laryngoscopy for TVFI. Studies were excluded if there were insufficient data to compute a sensitivity/specificity table after attempting to contact the authors. Case reports, and case series were also excluded. The initial search returned 1357 citations. Of these, 109 were selected for review utilizing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Thirty citations describing 6033 patients were included in the final meta‐analysis. A bivariate random effects meta‐analysis was performed, revealing a pooled sensitivity for laryngeal US of 0.95 (95% confidence interval [CI] 0.88–0.98), a specificity of 0.99 (95% CI 0.97–0.99), and a diagnostic odds ratio of 1328.2 (95% CI 294.0–5996.5). The area under the curve of the hierarchical summary receiver operating characteristic curve was 0.99 (95% CI 0.98–1.00). Laryngeal US demonstrates high sensitivity and specificity for detecting VFI in the hands of clinicians directly providing care to patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Study Selection and Data Extractionmentioning

confidence: 99%

Laryngeal Ultrasound Detects Vocal Fold Immobility in Adults

Hamilton

Tawfik

et al. 2021

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

“…In our study, we placed the transducer directly on the VFs, the so-called direct approach. However, other researchers placed the transducer on the skin of the patient, which is called the transcutaneous approach [10,11,[13][14][15]54,[68][69][70]. In the direct approach, it was easy to identify the VFs, whereas in transcutaneous approaches, the visualization rate was only 36.7% for the true VFs [71].…”

Section: Measurements On the Vfsmentioning

confidence: 99%

“…US is already being used to examine the vocal folds, like B-mode- [10], Doppler- [11], Nakagami-imaging [12], and elastography [13][14][15]. These imaging techniques, except B-mode-imaging, display the elastic characteristics of the vocal folds directly or indirectly [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging the Vocal Folds: A Feasibility Study on Strain Imaging and Elastography of Porcine Vocal Folds

et al. 2019

View full text Add to dashboard Cite

Vocal folds are an essential part of human voice production. The biomechanical properties are a good indicator for pathological changes. In particular, as an oscillation system, changes in the biomechanical properties have an impact on the vibration behavior. Subsequently, those changes could lead to voice-related disturbances. However, no existing examination combines biomechanical properties and spatial imaging. Therefore, we propose an image registration-based approach, using ultrasound in order to gain this information synchronously. We used a quasi-static load to compress the tissue and measured the displacement by image registration. The strain distribution was directly calculated from the displacement field, whereas the elastic properties were estimated by a finite element model. In order to show the feasibility and reliability of the algorithm, we tested it on gelatin phantoms. Further, by examining ex vivo porcine vocal folds, we were able to show the practicability of the approach. We displayed the strain distribution in the tissue and the elastic properties of the vocal folds. The results were superimposed on the corresponding ultrasound images. The findings are promising and show the feasibility of the suggested approach. Possible applications are in improved diagnosis of voice disorders, by measuring the biomechanical properties of the vocal folds with ultrasound. The transducer will be placed on the vocal folds of the anesthetized patient, and the elastic properties will be measured. Further, the understanding of the vocal folds’ biomechanics and the voice forming process could benefit from it.

show abstract

Ultrasound Elastography Detects Age‐Related Changes in Adult False Vocal Folds

Chandra

Ortíz

Weitzel

et al. 2022

J of Ultrasound Medicine

Self Cite

View full text Add to dashboard Cite

Purpose To investigate the feasibility of ultrasound elastography for assessing the symmetry in stiffness values and movements of both false vocal folds (FVFs). Methods After Institutional Review Board's approval and written informed consent obtained, we measured ultrasound strain and shear wave velocity (SWV) of the bilateral FVF in vocal fold abduction and adduction in 30 participants using a linear array transducer (4–10 MHz). Twenty‐eight participants met inclusion criteria as healthy subjects for analysis. Mean strain of FVF produced by FVF movement from abduction to adduction was analyzed using 2D speckle‐tracking software offline. A SWV ratio ([SWVadduction – SWabduction]/SWabduction) was developed to test the contractibility of FVF. Statistical analysis included one‐way ANOVA to test the difference in mean strain, SWV (adduction and abduction), and SWV ratio among the three age groups; linear regression to analyze correlations of stiffness and movement between the right and left FVF; and intraclass correlation coefficient (ICC) to examine intra‐ and interobserver reliability in performing shear wave elastography (SWE) of FVF. Results The 28 healthy participants were divided into 3 age groups (10 of young 20–44 years; 9 of mid‐age 45–64 years; and 9 of senior ≥65 years). The SWV in FVF abduction was higher and the SWV ratio was lower in seniors compared to young participants (P < .05). Good to excellent correlation of mean strain and SWV between both FVFs (R2 > 0.89). The reliability of performing SWE of FVF was moderate to excellent. Conclusion Ultrasound elastography is feasible to assess the stiffness, dynamic movement, and symmetry of adult FVF, and healthy seniors may exhibit increased FVF stiffness.

show abstract

Ultrasound strain imaging in assessment of false vocal folds in adults: A feasibility study

Cited by 8 publications

References 24 publications

Laryngeal Ultrasound Detects Vocal Fold Immobility in Adults

Laryngeal Ultrasound Detects Vocal Fold Immobility in Adults

Imaging the Vocal Folds: A Feasibility Study on Strain Imaging and Elastography of Porcine Vocal Folds

Ultrasound Elastography Detects Age‐Related Changes in Adult False Vocal Folds

Contact Info

Product

Resources

About