Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice

Li, Pan; Zheng, Yuanyi; Ran, Haitao; Tan, Jinxiang; Lin, Yiguang; Zhang, Qunxia; Ren, Jianli; Wang, Zhigang

doi:10.1016/j.jconrel.2012.07.009

Cited by 105 publications

(59 citation statements)

References 39 publications

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“…[1][2][3][4] Targeted microbubbles (MBs) have been the most prevalent form of US molecular probes, which have been used to diagnose tumor, inflammatory lesions, atherosclerotic plaque, and thrombi. The applications of molecular US have been expanded to targeting therapy since MBs could serve as drug carriers for local release in combination with US-targeted MB destruction, which provides a novel and powerful tool for tumor targeting imaging, therapy, monitoring, and treatment evaluation.…”

Section: Introductionmentioning

confidence: 99%

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

Liu¹,

Shang²,

Wang³

et al. 2017

IJN

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The commonly used ultrasound (US) molecular probes, such as targeted microbubbles and perfluorocarbon emulsions, present a number of inherent problems including the conflict between US visualization and particle penetration. This study describes the successful fabrication of phase changeable folate-targeted perfluoropentane nanodroplets (termed FA-NDs), a novel US molecular probe for tumor molecular imaging with US. Notably, these FA-NDs can be triggered by low-intensity focused US (LIFU) sonication, providing excellent US enhancement in B-mode and contrast-enhanced US mode in vitro. After intravenous administration into nude mice bearing SKOV3 ovarian carcinomas, 1,1′-dioctadecyl-3,3,3′,3′ -tetramethylindotricarbocya-nine iodide-labeled FA-NDs were found to accumulate in the tumor region. FA-NDs injection followed by LIFU sonication exhibited remarkable US contrast enhancement in the tumor region. In conclusion, combining our elaborately developed FA-NDs with LIFU sonication provides a potential protocol for US molecular imaging in folate receptor-overexpressing tumors.

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Section: Introductionmentioning

confidence: 99%

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

Liu¹,

Shang²,

Wang³

et al. 2017

IJN

Self Cite

View full text Add to dashboard Cite

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“…The heavy radioisotopes such as In anti-mesothelin monoclonal antibody (Mab) targeting antigens for malignant mesothelioma, the dual-modality imaging probe was suggested for MRI/SPECT. They results showed great uptake of 111 In-MabMB-SPION and signal drop after 24 hrs post-injection.…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 90%

Molecular imaging modalities using nanoprobes for cancer diagnosis

Shahbazi‐Gahrouei¹,

P²,

B³

et al. 2018

Preprint

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Molecular imaging modalities are used for different type of cancers detection and diagnosis. In recent few years, there has been an increased focus on developing novel nanoparticles as new imaging contrast agents for early detection of cancer. The aim of this review article is to summarize molecular imaging technologies accompanying with using nanoparticles to improve potential imaging for cancer detection and hence valuable therapy in the future.Nanoprobes are rapidly becoming potentially transformative tools on cancer diagnostics for a wide range of imaging modalities such as CT, MRI, SPECT, PET, Ultrasound and Optical imaging. The study results seen in the recent literature are provided and discussed the diagnostic performance of imaging modalities for cancer diagnosis and their future directions.With knowledge of the correlation between the application of nanoparticles and molecular imaging modalities and with the development of targeted contrast agents or nanoprobes, they may provide better cancer diagnosis in the future.

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“…20 They were also developed as a carrier of drugs and genes that can be released in a targeted manner for therapy using ultrasound irradiation. [21][22][23] UTMD also reportedly increases renal interstitial permeability, 24,25 which increases the intercellular gap and changes the microenvironment. In addition, the beneficial involvement of endocrine cytokines after UTMD improves the implantation of MSCs.…”

Section: Introductionmentioning

confidence: 98%

Ultrasound-targeted stromal cell-derived factor-1-loaded microbubble destruction promotes mesenchymal stem cell homing to kidneys in diabetic nephropathy rats

Wu¹,

Li²,

Gong³

et al. 2014

IJN

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Mesenchymal stem cell (MSC) therapy has been considered a promising strategy to cure diabetic nephropathy (DN). However, insufficient MSCs can settle in injured kidneys, which constitute one of the major barriers to the effective implementation of MSC therapy. Stromal cell-derived factor-1 (SDF-1) plays a vital role in MSC migration and involves activation, mobilization, homing, and retention, which are presumably related to the poor homing in DN therapy. Ultrasound-targeted microbubble destruction has become one of the most promising strategies for the targeted delivery of drugs and genes. To improve MSC homing to DN kidneys, we present a strategy to increase SDF-1 via ultrasound-targeted microbubble destruction. In this study, we developed SDF-1-loaded microbubbles (MB SDF-1 ) via covalent conjugation. The characterization and bioactivity of MB SDF-1 were assessed in vitro. Target release in the targeted kidneys was triggered with diagnostic ultrasound in combination with MB SDF-1 . The related bioeffects were also elucidated. Early DN was induced in rats with streptozotocin. Green fluorescent protein-labeled MSCs were transplanted intravenously following the target release of SDF-1 in the kidneys of normal and DN rats. The homing efficacy was assessed by detecting the implanted exogenous MSCs at 24 hours. The in vitro results showed an impressive SDF-1 loading efficacy of 79% and a loading content of 15.8 μg/mL. MB SDF-1 remained bioactive as a chemoattractant. In the in vivo study, SDF-1 was successfully released in the targeted kidneys. The homing efficacy of MSCs to DN kidneys after the target release of SDF-1 was remarkably ameliorated at 24 hours compared with control treatments in normal rats and DN rats. In conclusion, ultrasound-targeted MB SDF-1 destruction could promote the homing of MSCs to early DN kidneys and provide a novel potential therapeutic approach for DN kidney repair.

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Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice

Cited by 105 publications

References 39 publications

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

Molecular imaging modalities using nanoprobes for cancer diagnosis

Ultrasound-targeted stromal cell-derived factor-1-loaded microbubble destruction promotes mesenchymal stem cell homing to kidneys in diabetic nephropathy rats

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