Ultrasound triggered organic mechanoluminescence materials

Wang, Wenliang; Tasset, Aaron; Pyatnitskiy, Ilya; Mohamed, Heba G.; Taniguchi, Rayna; Zhou, Richard; Rana, Manini; Lin, Peter; Capocyan, Sam Lander C; Bellamkonda, Arjun; Sanders, W Chase; Wang, Shuangfeng

doi:10.1016/j.addr.2022.114343

Cited by 30 publications

(22 citation statements)

References 171 publications

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“…Recently, we developed inorganic zinc sulfide nanoparticles co-doped with silver and cobalt (ZnS/Ag,Co@ZnS) to convert ultrasound wave to light for optogenetic stimulation. , However, ZnS/Ag,Co@ZnS nanoparticles required charging with 400 nm light outside the brain before use, and these non-biodegradable inorganic nanoparticles may generally undergo bioaccumulation and bioaugmentation of heavy metals in organs. − It is desirable to develop more biocompatible organic materials as mechanoluminescent materials for sono-optogenetics. Generally, ultrasound-induced piezoelectric effects and cycloreversions dominated the development of mechanoluminescent organic materials . One example would be dioxetane crosslinked solid polymers to achieve FUS-derived blue light emission due to the cycloreversions under high intensity ultrasound stimulation .…”

Section: Introductionmentioning

confidence: 99%

“…12−15 While FUS was experiencing rapid development for biomedical applications, ultrasound-triggered noninvasive optogenetics was still in its infancy due to the limited progress in mechanoluminescence materials. 16 Recently, we developed inorganic zinc sulfide nanoparticles co-doped with silver and cobalt (ZnS/Ag,Co@ZnS) to convert ultrasound wave to light for optogenetic stimulation. 17,18 However, ZnS/Ag,Co@ZnS nanoparticles required charging with 400 nm light outside the brain before use, and these non-biodegradable inorganic nanoparticles may generally undergo bioaccumulation and bioaugmentation of heavy metals in organs.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Generally, ultrasound-induced piezoelectric effects and cycloreversions dominated the development of mechanoluminescent organic materials. 16 One example would be dioxetane crosslinked solid polymers to achieve FUS-derived blue light emission due to the cycloreversions under high intensity ultrasound stimulation. 17 While all of these mechanoluminescent materials can produce light emission in the bulk form, 16 there is not yet a biocompatible liquid-phase mechanoluminescent materials system for non-invasive sono-optogenetics.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Focused ultrasound (FUS) represents one form of a wireless energy harvesting strategy that has been recently developed for noninvasive local brain anesthesia, sonodynamic therapy, and chemogenetics for brain stimulation due to its superior tissue penetration depth exceeding 10 cm and biosafety. − While FUS was experiencing rapid development for biomedical applications, ultrasound-triggered noninvasive optogenetics was still in its infancy due to the limited progress in mechanoluminescence materials . Recently, we developed inorganic zinc sulfide nanoparticles co-doped with silver and cobalt (ZnS/Ag,Co@ZnS) to convert ultrasound wave to light for optogenetic stimulation. , However, ZnS/Ag,Co@ZnS nanoparticles required charging with 400 nm light outside the brain before use, and these non-biodegradable inorganic nanoparticles may generally undergo bioaccumulation and bioaugmentation of heavy metals in organs. − It is desirable to develop more biocompatible organic materials as mechanoluminescent materials for sono-optogenetics.…”

Section: Introductionmentioning

confidence: 99%

“…One example would be dioxetane crosslinked solid polymers to achieve FUS-derived blue light emission due to the cycloreversions under high intensity ultrasound stimulation . While all of these mechanoluminescent materials can produce light emission in the bulk form, there is not yet a biocompatible liquid-phase mechanoluminescent materials system for non-invasive sono-optogenetics. To uncover the potential of mechanoluminescence in noninvasive brain stimulation, it is necessary to develop other mechanoluminescent materials to extend the toolbox of ultrasound-induced mechanophores. − …”

Section: Introductionmentioning

confidence: 99%

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Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics

Wang

Tang

et al. 2023

J. Am. Chem. Soc.

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Optogenetics has revolutionized neuroscience understanding by allowing spatiotemporal control over cell-type specific neurons in neural circuits. However, the sluggish development of noninvasive photon delivery in the brain has limited the clinical application of optogenetics. Focused ultrasound (FUS)-derived mechanoluminescence has emerged as a promising tool for in situ photon emission, but there is not yet a biocompatible liquid-phase mechanoluminescence system for spatiotemporal optogenetics. To achieve noninvasive optogenetics with a high temporal resolution and desirable biocompatibility, we have developed liposome (Lipo@IR780/L012) nanoparticles for FUS-triggered mechanoluminescence in brain photon delivery. Synchronized and stable blue light emission was generated in solution under FUS irradiation due to the cascade reactions in liposomes. In vitro tests revealed that Lipo@IR780/L012 could be triggered by FUS for light emission at different stimulation frequencies, resulting in activation of opsin-expressing spiking HEK cells under the FUS irradiation. In vivo optogenetic stimulation further demonstrated that motor cortex neurons could be noninvasively and reversibly activated under the repetitive FUS irradiation after intravenous injection of lipid nanoparticles to achieve limb movements.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics

Wang

Tang

et al. 2023

J. Am. Chem. Soc.

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Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Liu

Mehrjou

et al. 2023

Advanced Materials

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The discovery of antibiotics has saved millions of lives, but the emergence of antibiotic‐resistant bacteria has become another problem in modern medicine. To avoid or reduce the overuse of antibiotics in antibacterial treatments, stimuli‐responsive materials, pathogen‐targeting nanoparticles, immunogenic nano‐toxoids, and biomimetic materials are being developed to make sterilization better and smarter than conventional therapies. The common goal of smart antibacterial materials (SAMs) is to increase the antibiotic efficacy or function via an antibacterial mechanism different from that of antibiotics in order to increase the antibacterial and biological properties while reducing the risk of drug resistance. The research and development of SAMs are increasingly interdisciplinary because new designs require the knowledge of different fields and input/collaboration from scientists in different fields. A good understanding of energy conversion in materials, physiological characteristics in cells and bacteria, and bactericidal structures and components in nature are expected to promote the development of SAMs. In this review, the importance of multidisciplinary insights for SAMs is emphasized, and the latest advances in SAMs are categorized and discussed according to the pertinent disciplines including materials science, physiology, and biomimicry.This article is protected by copyright. All rights reserved

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Achieving Ultrasound‐Excited Emission with Organic Mechanoluminescent Materials

Chang,

Gu,

Yuan

et al. 2024

Advanced Materials

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Unlike traditional photoluminescence (PL), mechanoluminescence (ML) achieved under mechanical excitation demonstrates unique characteristics such as high penetrability, spatial resolution, and signal‐to‐background ratio (SBR) for bioimaging applications. However, bioimaging with organic mechanoluminescent materials remains challenging because of the shallow penetration depth of ML with short emission wavelengths and the absence of a suitable mechanical force to generate ML in vivo. To resolve these issues, the present paper reports the achievement of ultrasound (US)‐excited fluorescence and phosphorescence from purely organic luminogens for the first time with emission wavelengths extending to the red/NIR region, with the penetrability of the US‐excited emission being considerably higher than that of PL. Consequently, US‐excited subcutaneous phosphorescence imaging can be achieved using a mechanoluminescent‐luminogen‐based capsule device with a quantified intensity of 9.15 ± 1.32 × 104 p s−1 cm−2 sr−1 and an SBR of 24. Moreover, the US‐excited emission can be adequately tuned using the packing modes of the conjugated skeletons, dipole orientation of mechanoluminescent luminogens, and strength and direction of intermolecular interactions. Overall, this study innovatively expands the kind of excitation sources and the emission wavelengths of organic mechanoluminescent materials, paving the way for practical biological applications based on US‐excited emission.

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Ultrasound triggered organic mechanoluminescence materials

Cited by 30 publications

References 171 publications

Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics

Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Achieving Ultrasound‐Excited Emission with Organic Mechanoluminescent Materials

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