Ultrasound-Triggered Smart Drug Release from Multifunctional Core−Shell Capsules One-Step Fabricated by Coaxial Electrospray Method

Jing, Yujia; Zhu, Yihua; Yang, Xin; Shen, Jianhua; Li, Chunzhong

doi:10.1021/la1042734

Cited by 126 publications

(72 citation statements)

References 34 publications

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“…51 By making a careful selection, it was also possible for the polymeric shell to act as a physical support for core-embedded drug. 71 However, the size and internal structure of core-shell particles have to be precisely controlled, since the release kinetics is mainly determined by drug diffusion through the polymeric shell. 37 It was demonstrated that the coaxial dual-capillary electrospray is capable of producing monodisperse drug-loaded particles with high encapsulation efficiency.…”

Section: Coaxial Electrosprayingmentioning

confidence: 99%

“…These smart delivery systems enable controlled release of drugs as a response to changes in chemical or physical conditions. 71 With the capability of electrospraying in producing inorganic particles, multifunctional paclitaxel-loaded core-shell particles with ultrasoundtriggered release properties were fabricated in a single step. Initial burst release together with paclitaxel release rate was successfully controlled by ultrasound stimulated cracking of the TiO 2 shell.…”

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confidence: 99%

“…37,38,71,128 Electrosprayed polymeric particles are also beneficial for formulation of poorly water-soluble drugs for oral administration in order to shield the drug from biological processes, like undergoing high gut wall and first-pass metabolism. Coaxial EHDA was utilized for fabrication of core-shell PLGA particles containing estradiol, the prescribed therapeutic agent for menopausal symptoms and prevention of postmenopausal osteoporosis.…”

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confidence: 99%

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Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

204

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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Section: Coaxial Electrosprayingmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

204

104

View full text Add to dashboard Cite

show abstract

“…In the context of drug delivery carriers, the inner cavity of such particles can store large amounts of drugs, and the encapsulating porous shells provides delivery pathway for drug molecules diffusion. The porous shelled drug carriers are also shown to be mechanically more stable than some other drug carriers, such as those made of polymers, which have revealed a naturally burst release behavior (Jing et al 2011). …”

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confidence: 99%

Application of Acoustic Bessel Beams for Handling of Hollow Porous Spheres

Azarpeyvand

2014

Ultrasound in Medicine & Biology

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ABSTRACT-Acoustic manipulation of porous spherical shells, widely used as drug delivery carriers and magnetic resonance imaging contrast agents, is investigated analytically. The technique used for this purpose is based on the application of high-order Bessel beams for as a single-beam acoustic manipulation device, using which particles lying on the axis of the beam can be pulled toward the beam source. The exerted acoustic radiation force is calculated using the standard partial-wave series method and the wave propagation within the porous media is modeled using Biot's theory of poroelasticity. Numerical simulations are performed for porous aluminum and silica shells of different thicknesses and porosities.Results have shown that manipulation of low-porosity shells is possible using Bessel beams with large conical angles, over a number of broadband frequency ranges; while that for highly porous shells generally occurs over some narrowband frequency domains at much smaller conical angles.

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“…Two types of mechanisms trigger the release from a capsule: an internal stimulus (e.g., changes of pH [4] or ionic strength of the solution [44]) or an external stimulus (e.g., light [46], magnetic or electric field [47,48], or ultrasound irradiation [49]). The microcapsule response may be based on either the intrinsic properties of the shell or the content of the capsule, and it is sensitive to the trigger impact [50,51].…”

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confidence: 99%

Patchy colloidosomes – an emerging class of structures

Rozynek

Józefczak

2016

Eur. Phys. J. Spec. Top.

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Abstract.A colloidosome, i.e., a selectively permeable capsule composed of colloidal particles forming a stable homogenous shell, is a tiny container that can be used for storage, transportation, and release of cargo species. There are many routes to preparing colloidosomes; dozens of examples of future applications of such colloidal capsules have been demonstrated. Their functionality can be further extended if the capsules are designed to have heterogeneous shells, i.e., one or more regions (patches) of a shell are composed of material with specific properties that differ from the rest of the shell. Such patchy colloidosomes, supplemented by functionalities similar to that offered by well-studied patchy particles, will surely possess advantageous properties when compared with their homogenous counterparts. For example, owing to specific interactions between patches, they either can self-assemble into complex structures; specifically adhere to a surface; release their cargo species in specific direction; or guided-align,-orient or -propel. Fabrication of patchy colloidal microcapsules has long been theorized by scientists able to design different models, but actual large-scale production remains a challenge. Until now, only a few methods for fabricating patchy colloidosomes have been demonstrated, and these include production by means of microfluidics and mechanical pipetting. The field of science related to fabrication and application of patchy colloidosomes is clearly unexplored, and we envision it blooming in the coming years.

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Ultrasound-Triggered Smart Drug Release from Multifunctional Core−Shell Capsules One-Step Fabricated by Coaxial Electrospray Method

Cited by 126 publications

References 34 publications

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Application of Acoustic Bessel Beams for Handling of Hollow Porous Spheres

Patchy colloidosomes – an emerging class of structures

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