Ultrasound velocity and attenuation of porcine soft tissues with respect to structure and composition: I. Muscle

Koch, Tim; Lakshmanan, S.; Brand, Sebastian; Wicke, Michael; Raum, Kay; Mörlein, Daniel

doi:10.1016/j.meatsci.2010.12.002

Cited by 34 publications

(13 citation statements)

References 40 publications

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“…The attenuation coefficients of subcutaneous fat, muscle, and bone for 16 ex vivo swine-tissue samples are summarized in Table 1. The attenuation coefficients of subcutaneous fat and muscle were similar to the reported values of 1.6-2.7 and 1.0-1.2 dB/cm/MHz, respectively [21], [22]. Figure 4 depicts the relationship between tissue thicknesses measured via the proposed ultrasound method and MR imaging.…”

Section: Resultssupporting

confidence: 77%

Ultrasound Signal Processing Technique for Subcutaneous-Fat and Muscle Thicknesses Measurements

Park

Chung

2019

IEEE Access

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Accurate body-composition measurements are important for diagnosing health status. Devices used for body-composition measurement should be easily accessible for patient diagnosis whilst realizing high inter-and intra-operator accuracies for repetitive measurements. Dual-energy X-ray absorptiometry and magnetic resonance imaging (MRI) have been considered as a gold-standard method. However, these methods have disadvantages such as limited accessibility, high costs, and long scanning times. Ultrasound imaging is an alternative technique for body-composition measurement owing to its easy accessibility and convenience of use. Current ultrasound imaging techniques identify the interface between different tissue layers based on echogenicity changes observed in ultrasound images. Their measurement accuracies, therefore, depend on the ultrasound image quality and operator interpretation. Radio-frequency (RF) signals obtained directly from an ultrasound system ensure the reproducibility of measurements. However, RF signals contain substantial noise, and signal processing is fundamental in body-composition measurements. This study proposes an ultrasound signal processing technique to measure body composition. Backscattered RF signals in ex vivo swine-tissue samples were first acquired from an ultrasound system. Subsequently, interfaces of subcutaneous-fat, muscle, and bone were identified during RF signal processing. Next, subcutaneous-fat and muscle thicknesses were calculated based on the speed of sound through tissue. Lastly, the subcutaneous-fat and muscle thicknesses measured using ultrasound signals were validated using MRI scans. A strong linear correlation was observed between the proposed ultrasound method and MRI. Thickness correlations between ultrasound and MRI were observed to be 0.899 and 0.982 for subcutaneous-fat and muscle, respectively. The proposed technique, therefore, demonstrates clinical potential for body-composition measurements. INDEX TERMS Body composition, signal processing, time of flight, acoustic attenuation, ultrasound.

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Section: Resultssupporting

confidence: 77%

Ultrasound Signal Processing Technique for Subcutaneous-Fat and Muscle Thicknesses Measurements

Park

Chung

2019

IEEE Access

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“…A second challenge arises because acoustic attenuation due to absorption and scattering varies between different US propagation paths in heterogeneous tissue; a path with higher attenuation may significantly degrade system power transfer efficiency and data transfer reliability. For example, muscle tissue with a more unevenly distributed intramuscular fat content will exhibit greater acoustic attenuation 45 . Here, an external transceiver with a large-aperture, multi-element transducer array capable of focusing energy to the implant will allow steering of the US beam along a preferred path.…”

Section: Discussionmentioning

confidence: 99%

Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant

et al. 2021

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“…A second challenge arises because acoustic attenuation due to scattering and absorption varies between different US propagation paths to the implant in heterogeneous tissue; a path with higher attenuation in tissue may significantly degrade power transfer efficiency and data transfer reliability of the system. For example, muscle tissue with a more unevenly distributed intramuscular fat content will exhibit greater acoustic attenuation 80 . Here too, an external transceiver with a large-aperture, multi-element transducer array capable of focusing US energy to the implant will allow for steering the US beam along a preferred path.…”

Section: Discussionmentioning

confidence: 99%

Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant

Sonmezoglu

Fineman

Maltepe

et al. 2021

Preprint

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Deep tissue oxygenation monitoring has many potential applications. Vascular complications after solid organ transplantation, for example, frequently lead to graft ischemia, dysfunction or loss, and can occur months after transplantation. While imaging approaches can provide intermittent assessments of graft perfusion, they require highly skilled practitioners, and fail to directly assess graft oxygenation. Existing tissue oxygen monitoring systems have many drawbacks, including the need for wired connections, the inability to provide real-time data, and, crucially, an operation that is limited to surface tissues. Here, we present the first wireless, minimally-invasive deep tissue oxygen monitoring system that provides continuous real-time data from centimeter-scale depths in a clinically-relevant large animal (sheep) model and demonstrates operation at great depths (up to 10 cm) through ex vivo porcine tissue. The system relies on a millimeter-sized, wireless, battery-free, implantable luminescence oxygen sensor that is powered by ultrasound and capable of bi-directional data transfer with an external transceiver. We present various aspects of system and sensor performance and demonstrate the operation of the system in vitro in distilled water, phosphate-buffered saline (PBS) and undiluted human serum, ex vivo through porcine tissue, and in vivo in a sheep model. We believe this technology represents a new class of diagnostic system particularly suitable for organ monitoring, as well as other surgical or critical care indications.

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Ultrasound velocity and attenuation of porcine soft tissues with respect to structure and composition: I. Muscle

Cited by 34 publications

References 40 publications

Ultrasound Signal Processing Technique for Subcutaneous-Fat and Muscle Thicknesses Measurements

Ultrasound Signal Processing Technique for Subcutaneous-Fat and Muscle Thicknesses Measurements

Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant

Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant

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