Ultrassonografia e histopatologia renal em cães

PURPOSE:The use of the collared peccary as an experimental model for ischemic nephropathy. METHODS:A total of 12 collared peccary (Tayassu tajacu) was used and ischemic nephropathy was induced in six of these animals that constituted the experimental group (G1) while the other six formed the control group (G2). Ischemic nephropathy was induced surgically by partial occlusion of the left renal artery. The disease course was assessed by hematological tests, serum chemistry, urinalysis, ultrasound (US) and doppler ultrasound function of the renal artery before induction, and at five, 10, 15 and 20 days after surgery.Twenty days after the occlusion, unilateral nephrectomy and histopathological examination were performed to assess renal morphology. RESULTS:Statistical analysis by Fischer's test showed a significant difference (p<0.05) between the control group and the experimental group. The histopathological examination showed glomerular, tubular and interstitial lesions. In the experimental group, 83.3% (5 /6) showed moderate renal lesions and only 16.7% (1/6) were classified with no lesions. The ultrasound examination of the right kidney presented statistical difference between day 5 and day 10 post occlusion. CONCLUSION:The collared peccary as a good experimental model for ischemic renal disease, because it could be manipulated during the research time without death, with health conditions that permit any subsequent procedure for disease therapy.Key words: Artiodactyla. Kidney Diseases. Ischemia. Models, Animal. Collared Pecary (tayassu tajacu) as a new model of renal ischemic injury induced by clamping the renal arteryActa Cirúrgica 2014 -561

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“…This fact has been observed in studies on the correlation of sonographic and histopathological findings in renal diseases 45 .…”

Section: Resultssupporting

confidence: 53%

Collared Pecary (tayassu tajacu) as a new model of renal ischemic injury induced by clamping the renal artery

et al. 2014

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“…Burti et al (2020) demonstrated that the number and severity of ultrasound changes are correlated with the severity of kidney degeneration lesions on histopathological examination. Therefore, even if the specific diagnosis is not achieved by the method, it brings enough information to guide future procedures (Carvalho et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The literature considers that in cases of AKI, hyp-erechogenicity is due to the presence of inflammatory infiltrate, proteins, cylinders, and calcium and is directly related to the presence of interstitial changes and loss of renal function (Pennick and D'Anjou, 2015;Garreballah et al, 2015). The correlation between cortical hyperechogenicity, histological abnormalities, and increase in serum creatinine suggests that high-risk patients may have kidney damage (Araujo et al, 2010;Carvalho et al, 2010;Bragato et al, 2017). Therefore, due to its high prevalence, cortical hyperechogenicity may represent a sentinel sign of renal dysfunction also in those animals with mean serum creatinine values below 1.6 mg / dl if they have risk factors for the development of kidney injury.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in renal size, such as renomegaly, are considered typical in patients with AKI, usually due to the presence of interstitial edema, inflammation, and renal congestion (Carvalho et al, 2010;Rivera, 2014;Pennick and D'Anjou, 2015). However, occurrence varies with the intensity, duration of the insult, and the degree of hydration of the patient (Schmidt, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Souza

Muniz

Costa-Val

et al. 2022

Arq. Bras. Med. Vet. Zootec.

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Acute kidney injury (AKI) is defined as the rapid decline in kidney function. Its development is related to critical clinical statuses, such as sepsis, complicated post-surgical recovery, and infectious diseases. Serum cystatin C (CysC) has the best correlation with the glomerular filtration rate. Ultrasonography stands out because it is highly accessible and can be done at the bedside. Twenty-eight dogs admitted to the intensive care unit with serum creatinine values <1.6 mg/dL and at-risk factors of AKI development were selected. CysC measurements and ultrasound assessments were performed daily for 72 hours. Using CysC dosage, 22/28 animals (78.6%) were considered to have AKI, and 17/22 had ultrasound compatible with AKI changes, demonstrating moderate agreement with CysC dosage. Increased cortical renal echogenicity is the most prevalent alteration in critically ill patients and is correlated with serum increases in CysC and is associated with renal structural damage.

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“…Tais características também foram utilizadas por Carvalho et al (2010), que comparam os resultados dos achados ultrassonográficos com a histologia de tecidos renais. Dos 26 cães estudados, 11 apresentaram algum tipo de alteração no exame ultrassonográfico que compreenderam alterações de ecogenicidade, alterações no tamanho renal, alterações na relação entre as regiões cortical e medular, alteração de contorno e na ecotextura dos tecidos renais.…”

Section: Discussionunclassified

Estudo morfométrico de rins em felinos domésticos (Felis catus)

et al. 2016

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ABSTRACT.-Agopian R.G., Guimarães K.P., Fernandes R.A., Silva M.V.M., Righetti M.M.S., Prisco C.R.D., Bombonato P.P. & Liberti E. A. 2016 Renal health has over the last few years called attention of veterinarians, because the chronic failure of the kidneyu is a major cause of morbidity and mortality in cats. This paper proposes biometric characterization of the kidneys from cats, Felis catus, on the macroscopic aspects (length, height, width, weight and volume), mesoscopic (height of the cortex and medulla, and their inter-relationship) and microscopic (glomerular volume) in order to establish possible differences arising from age, gender and bilateral symmetry. It where used 30 kidneys of animals from specie Felis catus (cat), 15 males and 15 females with ages between 3 months to 15 years, divided into three groups: group 1 (3-9 months), group 2 (3 -5 years) and group 3 (above 10 years). The kidneys were photographed, weighed, measured and processed for histology. The glomerular volume was obtained by stereology. The macroscopic data allowed to observe a morphometric and morphologic impartiality when compared sides, regardless of group and sex, about the length, height, width, weight and kidney volume. Significant difference was detected between males and females regardless of age for length, height, weight and volume, except for the width. There was a significant difference for all parameters considering the age: length, height, width, weight and volume. Wasnt detected signficant diferences between left and right kdney measurements of cortex, medulla and their inter-relationship, when considered bilateral symmetry. No difference was detected between males and females in mesoscopy in the cortex, medulla and cortex interrelationship cortex/medulla. Regarding age, the measurement of the height of the cortex and the interrelationship cortex/medulla showed a significant difference, but this difference was not established to the medulla of the kidney. Significant differences were found between groups, males and females, compared to the volume occupied by the glomerulus on the parenchyma renal. In all of biometric techniques there wasnt differences between right and left kidneys. The macroscopic measurements showed that males had larger kidney when compared length, height, width, weight and volume than females. The age range is directly related to the size of the kidney, which grows in all dimensions, gets heavier and with higher volume when compared young adults, and shows morphometry stability in relation to adults and senile. The renal parenchyma did not differ between the sexes, but the height of the cortex and the medulla ratio increases with age. The volume of the renal glomerulus is higher in males than in females and also increases in with the age. The kidneys showed a predominance of type I collagen in group 1 and 2, and type III collagen in group 3.

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Ultrassonografia e histopatologia renal em cães

Abstract: ABSTRACT

Cited by 4 publications

References 6 publications

Collared Pecary (tayassu tajacu) as a new model of renal ischemic injury induced by clamping the renal artery

Collared Pecary (tayassu tajacu) as a new model of renal ischemic injury induced by clamping the renal artery

Correlation between renal ultrasonography and serum cystatin C in acute kidney disease of critically ill dogs

Estudo morfométrico de rins em felinos domésticos (Felis catus)

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