2007
DOI: 10.1590/s1678-77572007000400010
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Ultrastructural and immunohistochemical study of the influence of fluoride excess on the development of rat incisor tooth buds

Abstract: Little information is available on the pathogenesis of fluorosis during the fetal and initial postnatal period. In the present study, female rats received 0 (control), 7 or 100 ppm of sodium fluoride in drinking water, one week before breeding and throughout gestation and nursing periods. The hemimandibles of the offspring were collected at 0, 7 and 14 days of postnatal life (n = 5) and processed for morphological analyses by light and electron microscopy, immunohistochemical analysis for amelogenin and morpho… Show more

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Cited by 7 publications
(2 citation statements)
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“…During pregnancy and lactation, although the transfer of fluoride from mother to fetus is regulated by the placenta and the transfer of plasma to breast milk is inhibited (76), fluoride concentrations in breast milk and amniotic fluid increase significantly after the intake of fluorinated foods (77)(78)(79)(80)(81). Excessive fluoride exposure results in increased organic material in the secretory stage of enamel formation.…”
Section: Fluorosis and Maternal Brick Tea Consumptionmentioning
confidence: 99%
“…During pregnancy and lactation, although the transfer of fluoride from mother to fetus is regulated by the placenta and the transfer of plasma to breast milk is inhibited (76), fluoride concentrations in breast milk and amniotic fluid increase significantly after the intake of fluorinated foods (77)(78)(79)(80)(81). Excessive fluoride exposure results in increased organic material in the secretory stage of enamel formation.…”
Section: Fluorosis and Maternal Brick Tea Consumptionmentioning
confidence: 99%
“…Early indications that excess fluoride may trigger an ER stress–like response in ameloblasts were provided by histological reports suggesting that fluoride disturbs ameloblast intracellular protein trafficking (Matsuo et al, 1996 ), including the retention of ER cargo and the appearance of a dilated ER (Hassunuma et al, 2007 ). These observations are consistent with ameloblasts suffering ER stress but the up-regulation of UPR components provides unequivocal evidence that the UPR is associated with the ameloblast response to fluoride.…”
Section: The Role Of the Upr In The Pathobiology Of Fluorosismentioning
confidence: 99%