Ultrastructural Demonstration of Type IV Collagen Deposits in Periductal Elastosis in Breast Cancer

Verhoeven, Didier; Bourgeois, N.; Buyssens, N; Marck, E. Van; Foidart, Jean‐Michel

doi:10.1016/s0344-0338(11)80084-1

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Structural defects of BL occurring in association with local invasion have already been studied and reported in various tumours of the uterine cervix [33], oral mucosa [27] and breast [6,10,39]. Many studies have also dealt with ultrastructural analysis, mainly of the BL and MCs, in benign and malignant breast tumours [10,23,37].…”

Section: Discussionmentioning

confidence: 99%

Myoepithelial cells and basal lamina in poorly differentiated in situ duct carcinoma of the breast

Damiani

Ludvíková²,

Tomasic³

et al. 1999

Virchows Archiv

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A retrospective study was made of 38 selected brest tumours with a poorly differentiated in situ duct component. These were classified on haematoxylin and eosin (H&E) as ductal carcinoma in situ (DCIS; 10 cases), DCIS with invasion (17 cases) and DCIS with features suggestive of for stromal invasion (11 cases). The last were these lesions composed of neoplastic ducts with irregular outlines and a myoepithelial layer that was not clearly evident or large neoplastic ducts growing close together or surrounded by inflammatory desmoplastic stroma. Cases of DCIS involving areas of sclerosing adenosis were included in this category. Consecutive sections obtained from each case were studied with a panel of antibodies against myoepithelial cells (alpha smooth muscle actin and calponin) and basal lamina (BL) components (laminin and type IV collagen). It was found that in situ lesions showed well-formed basal lamina and/or an evident myoepithelial layer. These features were lacking in the invasive areas. Nine of the 11 cases with suggestive features of stromal invasion were reclassified as invasive duct carcinoma (5 cases)and DCIS (4 cases), according to the absence or presence of a continuous myoepithelial layer and/or basal lamina. In 2 such cases immunohistochemistry yielded equivocal results and the label "suggestive of invasion" was therefore pertinent. Immunohistochemistry facilitates the diagnosis of breast DCIS; myoepithelial and basal lamina markers are useful in differentiating microinvasive from in situ ductal carcinomas of the breast.

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Section: Discussionmentioning

confidence: 99%

Myoepithelial cells and basal lamina in poorly differentiated in situ duct carcinoma of the breast

Damiani

Ludvíková²,

Tomasic³

et al. 1999

Virchows Archiv

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“…27 However, non-basement membrane type IV collagen is increased in elastotic tumor tissues of the breast. 28 …”

Section: Common Basement Membrane Componentsmentioning

confidence: 99%

Involvement of extracellular matrix constituents in breast cancer

Lochter

Bissell

1995

Seminars in Cancer Biology

168

136

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“…As mechanisms, elevated activity of lysyl oxidases and tissue transglutaminases in stromal cells mediate covalent collagen cross‐linking 104 and thereby enhance carcinoma cell invasion 105. Adhesion‐promoting additional ECM constituents, including laminin‐332 106, non‐basement membrane collagen IV 107, fibronectin 108, and elastin 102, are jointly synthesized by carcinoma cells themselves and stroma cells, and reinforce migration‐promoting activities, as suggested by their chemotaxis‐ and haptotaxis‐enhancing effects in vitro 109. Likewise, the composition of core proteins and glycosaminoglycan chains is altered in the ECM surrounding breast carcinoma.…”

Section: Guidance Of Breast Carcinoma Invasionmentioning

confidence: 99%

Cover Picture: Organocatalytic Domino Michael–Knoevenagel Condensation Reaction for the Synthesis of Optically Active 3‐Diethoxyphosphoryl‐2‐oxocyclohex‐3‐enecarboxylates (Chem. Eur. J. 13/2009)

Albrecht

Richter

Vila

et al. 2009

Chemistry A European J

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In Buddhist imagery the gestures of the hand are very significant, which reflects the themes of asymmetry and chirality (derived from the word “hand”) found in the Full Paper by K. A. Jørgensen et al. on page 3093 ff. The professor is shown as a Buddha‐like image and is gesturing down with one hand and making the Buddhist gesture for “method and wisdom” with the other. Dice tumbling from his hand represent the organocatalytic Michael–Knoevenagel condensation domino reaction discussed in the paper, with the front die representing the cyclohexenone center of the molecule being formed. The two students standing by are making Buddhist gestures for “accomplishment” and “meditation”. Artwork by cartoonist Jorge Cham, http://www.phdcomics.com.magnified image

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Ultrastructural Demonstration of Type IV Collagen Deposits in Periductal Elastosis in Breast Cancer

Cited by 6 publications

References 15 publications

Myoepithelial cells and basal lamina in poorly differentiated in situ duct carcinoma of the breast

Myoepithelial cells and basal lamina in poorly differentiated in situ duct carcinoma of the breast

Involvement of extracellular matrix constituents in breast cancer

Cover Picture: Organocatalytic Domino Michael–Knoevenagel Condensation Reaction for the Synthesis of Optically Active 3‐Diethoxyphosphoryl‐2‐oxocyclohex‐3‐enecarboxylates (Chem. Eur. J. 13/2009)

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