Ultrastructural Evidence of the Hepatotoxic Effect of Halothane in Rats Following in-Utero Exposure

Chang, Louis W.; Lee, K.; Dudley, Alden W.; Katz, Jordan

doi:10.1097/00132586-197604000-00010

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature reviews regarding halothane ( References 17,18,10,20) indicate the most widely accepted mechanism of bio-transformation is the production of trifluoroacetic acid and bromide. The literature regarding enflurane (References 21, 22) does not indicate any one accepted mechanism, but increased serum and urinary fluoride levels were found in patients receiving enflurane anesthesia.…”

Section: Toxicologicalmentioning

confidence: 99%

Health hazard evaluation report: HETA-87-130-1790, Primary Childrens Medical Center, Salt Lake City, Utah.

1987

View full text Add to dashboard Cite

Section: Toxicologicalmentioning

confidence: 99%

Health hazard evaluation report: HETA-87-130-1790, Primary Childrens Medical Center, Salt Lake City, Utah.

1987

View full text Add to dashboard Cite

“…The ASA study (2), as well as surveys by Knill-Jones et al (10) and Corbett et al (11) indicated an increased rate of congenital abnormalities in children of women with occupational exposures to anesthetic gases, and to wives of men with similar exposures. While most animal exposures studies have heen conducted at anesthetic levels, one study (15,16,17) indicated liver, kidney, and brain tissues changes in pups born to rats exposed to sub-anesthetic concentrations of halothane during pregnancy.…”

Section: Page 5 -Health Hazard Evaluation Determination Report No 77-85mentioning

confidence: 99%

Health hazard evaluation determination report no. HHE-77-85-445, Mesa Veterinary Hospital, Golden, Colorado.

1977

View full text Add to dashboard Cite

Golden, Colorado. On August 22 &24, 1977, environmental samples were col l ected to determine concentrations of waste anesthetic gases.Findings on the days of this evaluation indicate that the mean 8-hour time weighted average exposure to nitrous oxide was 34 ppm for the veterinarian and 45 ppm for the anesthesia technicians. Average exposure to halogenated anesthetic was 0.8 and 2.2 ppm for the same two groups. These concentrations were slightly above the NIOSH Recommended Limit of 25 ppm nitrous oxide and 0.5 ppm hal ogenated anesthetic. Since information on adverse health effects due to exposure to waste anesthetic gases is not completely definitive and many unknown factors still exist, recommended permissible levels of exposure are not defined as safe levels but rather as levels which are attainable with current technology. These levels should prevent the effects caused by acute exposure and significantly reduce the risk associated with long term, low level exposure . Recommendations to further reduce concentrations are included in this report.

show abstract

“…The ASA study (2), as well as surveys by Knill-Jones et al (10) and Corbett et al (11) indicated an increased rate of congenital abnormalities in children of women with occupational exposures to anesthetic gases, and to wives of men with similar exposures. While most animal exposures studies have been conducted at anesthetic levels, one study (15,16,17) indicated liver, kidney, and brain tissues changes in pups born to rats exposed to sub-anesthetic concentrations of halothane during pregnancy.…”

Section: Evaluation Criteriamentioning

confidence: 99%

Health hazard evaluation determination report no. HHE-76-113-385, Englewood Hospital, Englewood, New Jersey.

1977

View full text Add to dashboard Cite

A Health Hazard Evaluation was conducted by the National Institute for Occupational Safety and Health (NIOSH) in the operating room, recovery room, and delivery room areas of the Englewood, N.J., Hospital. On November 15-17, 1976, environmental samples were collected to determine the concentration of nitrous oxide, halothane, and enflurane in these areas.Findings of this evaluation indicate that the mean exposure of anesthesiologists to nitrous oxide was 160 ppm, and to halogenated anesthetic was l .4 ppm. The average exposure of nurses to halogenated anesthetic was 0.4 ppm. These concentrations exceed the NIOSH recommended limit of 25 ppm nitrous oxide and 0.5 ppm halogenated anethetic. Since information on adverse health effects due to exposure to waste anesthetic gases is not completely definitive and many unknown factors still exist, reconmended permissible levels of exposure are not defined as safe levels but rather as levels which are attainable with current technology. These levels should prevent the effects caused by acute exposure and significantly reduce the risk associated with long term, low level exposure. II. DISTRIBUTION AND AVAILABILITY OF DETERMINATION REPORT

show abstract

Ultrastructural Evidence of the Hepatotoxic Effect of Halothane in Rats Following in-Utero Exposure

Cited by 4 publications

References 0 publications

Health hazard evaluation report: HETA-87-130-1790, Primary Childrens Medical Center, Salt Lake City, Utah.

Health hazard evaluation report: HETA-87-130-1790, Primary Childrens Medical Center, Salt Lake City, Utah.

Health hazard evaluation determination report no. HHE-77-85-445, Mesa Veterinary Hospital, Golden, Colorado.

Health hazard evaluation determination report no. HHE-76-113-385, Englewood Hospital, Englewood, New Jersey.

Contact Info

Product

Resources

About