Ultrastructure and infectivity of tissues from normal and immunodepressed chickens inoculated with turkey herpesvirus

Prasad, L.B.M.; Spradbrow, P. B.

doi:10.1016/0021-9975(80)90027-4

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…The origin of HVT reduced loads compared to MDV remains unclear. Prasad and Spadbrow proposed that HVT would not be able to form enveloped mature virions in the skin [46]. However, a reduced replication ability or defective morphogenesis of HVT in chicken keratinocytes has not yet be proven.…”

Section: Discussionmentioning

confidence: 99%

Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies

Rémy

Pape

Gourichon

et al. 2020

Vet Res

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Marek's disease (MD) is a major disease of chickens induced by Marek's disease virus (MDV) associated to lethal lymphomas. Current MD vaccines protect against lymphomas, but fail to prevent infection and shedding. The control of MDV shedding is crucial in order to eradicate this highly contagious virus. Like pathogenic MDV, MD vaccines infect the feather follicles of the skin before being shed into the environment. MD vaccines constitute excellent models to study virus interaction with feathers, the unique excretion source of these viruses. Herein we studied the viral persistence in feathers of a MD vaccine, the recombinant turkey herpesvirus (rHVT-ND). We report that most of the birds showed a persistent HVT infection of feathers over 41 weeks with moderate viral loads. Interestingly, 20% of the birds were identified as low HVT producers, among which six birds cleared the infection. Indeed, after week 14-26, these birds named controllers had undetectable HVT DNA in their feathers through week 41. All vaccinated birds developed antibodies to NDV, which lasted until week 41 in 95% of the birds, including the controllers. No correlation was found between HVT loads in feathers and NDV antibody titers over time. Interestingly, no HVT DNA was detected in the spleens of four controllers. This is the first description of chickens that durably cleared MD vaccine infection of feathers suggesting that control of Mardivirus shedding is achievable by the host.

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Section: Discussionmentioning

confidence: 99%