Ultrastructure and Retinal Imaging of Internal Limiting Membrane

Mackenzie, Sarah E; Gandorfer, Arnd; Rohleder, Matthias; Schumann, Ricarda G.; Schlottmann, Patricio G.; Bunce, Catey; Xing, Wen; Gregor, Zdeněk; Charteris, David G.

doi:10.1097/iae.0b013e3181bced50

Cited by 11 publications

(3 citation statements)

References 23 publications

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“…Literatürde vitrektomiden 12 gün sonra gazla dolu bir gözde meydana gelen retinal arter tıkanıklığı ve başka bir hastada yüksek irtifa seyahatinden sonra oftalmik arter tıkanıklığının geliştiği vakalar yer almaktadır. 20 Vitrektomi ayrıca, büyük bir damar tıkanıklığı olmadan da göz içi hemodinamisi üzerinde görsel olarak önemli kalıcı etkilere sahip olabilir. Bu diyabetik retinopatili hastalarda postoperatif görme kaybını açıklamaktadır.…”

Section: Retina Ile İlgili Komplikasyonlar Retinal İskemiunclassified

“…Elektron mikroskobu çalışmaları, tripan mavisinin, ILM-retinal bölünme düzlemini değiştirebilen ICG'ye kıyasla, ILM'nin çıkarılması sırasında hücresel doku kaybına yol açmadığını göstermektedir. 20,45 Her ne kadar tripan mavisi, ICG'ye kıyasla daha masum gözükse de ICG kadar kapsamlı bir şekilde incelenmemekle birlikte bazı çalışmalar olası toksisiteleri düşündürmektedir. 46,47…”

Section: Tripan Mavisiunclassified

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Optic Nerve, Vitreous and Retinal Complications in Vitreoretinal Surgery

SÜMER

2023

CRJ

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Section: Retina Ile İlgili Komplikasyonlar Retinal İskemiunclassified

Section: Tripan Mavisiunclassified

Optic Nerve, Vitreous and Retinal Complications in Vitreoretinal Surgery

SÜMER

2023

CRJ

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“…This might be explained by differences in dye concentration, exposure time and degree of purity of the dyes used, as contamination of the dye with toxic side products has been observed [26]. Most clinical studies, however, suggest TB to be safe for use in chromovitrectomy [23,29,30,39,40,51,52,53,54,55,56,57]. BBG has been reported to be toxic in a dose-dependent manner in vitro [35].…”

Section: Figmentioning

confidence: 99%

Dyes for Eyes™: Hydrodynamics, Biocompatibility and Efficacy of ‘Heavy' (Dual) Dyes for Chromovitrectomy

Mohr

Bruinsma²,

Oellerich³

et al. 2013

Ophthalmologica

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As epiretinal membranes (ERMs), the internal limiting membrane (ILM) and the vitreous cortex are essentially transparent tissues, or translucent structures, nontraumatic removal may be challenging in various types of macular surgery. Vital dyes stain these thin tissues, thus allowing for better visualization of these structures during vitrectomy and selective ‘membrane peeling' from the underlying retina. To avoid swirling of the dye within the fluid-filled vitreous cavity, and to better target the dye onto the macula, a fluid-air exchange is commonly performed. However, this may jeopardize visualization of the macula during peeling due to clouding of the posterior lens capsule, and may lead to postoperative visual field defects. Recently, a new dye solution for staining the ERM and ILM simultaneously has been developed that circumvents the need for fluid-air exchange, i.e. MembraneBlue-Dual™. This paper will focus on the hydrodynamics and biocompatibility of this ‘heavy' dual dye and its efficacy for staining of the ILM and/or ERMs during posterior segment surgery in a multicenter clinical setting.

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Macular Hole Closure With Internal Limiting Membrane Abrasion Technique

et al. 2015

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Internal limiting membrane (ILM) abrasion is an alternative surgical technique for successful full-thickness macular hole (MH) repair. OBJECTIVE To study the effects of ILM abrasion as an alternative method of MH repair. DESIGN, SETTING, AND PARTICIPANTS Retrospective consecutive case series from January 2006 to December 2008. Demographic data and preoperative, intraoperative, and postoperative examination records of all patients were reviewed for patients who underwent ILM abrasion with a diamond-dusted membrane scraper during vitrectomy for MH repair. A total of 100 eyes underwent ILM abrasion as an alternative to traditional ILM peeling. MAIN OUTCOMES AND MEASURES Rate of MH closure and visual acuity (VA) outcomes at 3 months after surgery.RESULTS Macular hole closure was achieved with a single surgical procedure in 94 of 100 eyes (94.0%; 95% CI, 87.4%-97.8%). Among all patients, the median preoperative VA was 20/100 (range, 20/30 to hand motions; 25th quartile, 20/60; and 75th quartile, 20/160), and the median postoperative VA at 3 months after surgery was 20/60 (range, 20/20 to hand motions; 25th quartile, 20/40; and 75th quartile, 20/100). Among all patients with stage 2 MHs, 30 of 38 patients (78.9%) had at least 2 lines of VA gain: 15 of 23 (65.2%) were phakic, and 15 of 15 (100%) were pseudophakic. Four of 38 patients (10.5%) with stage 2 MHs had at least 2 lines of VA loss, and all were phakic. Among all patients with stage 3 or 4 MHs, 42 of 62 (67.7%) had at least 2 lines of VA gain, of which 30 of 38 (78.9%) were phakic and 22 of 24 (91.7%) were pseudophakic. Six of 62 patients (9.7%) with stage 3 or 4 MHs had at least 2 lines of VA loss: 4 were phakic, and 2 were pseudophakic. In total, 35.0% (95% CI, 25.7%-44.3%) of patients achieved 20/40 vision or better, and 52.0% (95% CI, 42.2%-61.8%) of patients achieved 20/50 vision or better.CONCLUSIONS AND RELEVANCE Abrasion of the ILM with a diamond-dusted membrane scraper at the time of vitrectomy achieves high rates of MH closure. This technique avoids complete removal of the retinal ILM basement membrane and subjacent tissues and appears to provide MH closure rates similar to those of traditional ILM peeling.

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Ultrastructure and Retinal Imaging of Internal Limiting Membrane

Abstract: Trypan blue stain from these data seems to improve the ease and completeness of the ILM peeling (assessed clinically) and does not show any signs of toxicity.

Cited by 11 publications

References 23 publications

Optic Nerve, Vitreous and Retinal Complications in Vitreoretinal Surgery

Optic Nerve, Vitreous and Retinal Complications in Vitreoretinal Surgery

Dyes for Eyes™: Hydrodynamics, Biocompatibility and Efficacy of ‘Heavy' (Dual) Dyes for Chromovitrectomy

Macular Hole Closure With Internal Limiting Membrane Abrasion Technique

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